Vitamin D and breast cancer: the therapeutic potential of new vitamin D analogues

in Endocrine-Related Cancer
Author: K W Colston
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INTRODUCTION Over the past two decades much has been learned about the metabolism and actions of vitamin D. Considered to be a dietary requirement essential for the prevention of rickets in the early years of this century, it is now clear that vitamin D is normally synthesized in adequate amounts in the skin by the actions of ultraviolet light. An exciting new area of research in the vitamin D field has opened up with the discovery of new target tissues, novel mechanisms of action and the synthesis of new analogues of vitamin D with tissue-selective actions and potential as therapeutic agents in a wide variety of clinical situations. This development has arisen from the realization that, in addition to its classical role as a calciotrophic hormone, the physiologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a wide range of biological effects in haemopoietic and

 

      Society for Endocrinology

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