A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats

in Endocrine-Related Cancer
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  • 1 Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
  • 2 Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA
  • 3 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
  • 4 Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia
  • 5 Section on Medical Neuroendocrinology, Eunice Kennedy Shriver Division National Institute of Child Health and Human Development, Bethesda, Maryland, USA
  • 6 Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
  • 7 Cyagen US Inc, Santa Clara, California, USA

Correspondence should be addressed to J F Powers: jpowers1@tuftsmedicalcenter.org

The authors and journal apologise for an error in the above paper, which appeared in volume 27 part 6, pages 337–354. The error relates to the artwork of Table 1 on page 346, in which the units were given in micromoles per milligram of tissue, when the units should have been given in nanomoles per milligram of tissue.

The correct Table 1 is given in full below:

Table 1

NMR metabolomic profiles of RS0, RS1/2 xenografts and rat adrenal medulla (RAM).

RS0 (n = 4)RS1/2 (n = 3)


RAM (20 pooled)
Mean ± s.e.m.Mean ± s.e.m.
The 10 most abundant detectable metabolites (nmol/mg of tissue)
 Epinephrine16.15Lactate15.18 ± 3.66Norepinephrine33.87 ± 29.41
 Norepinephrine12.33Taurine12.11 ± 2.69Lactate11.45 ± 2.18
 Glucose2.31Succinate5.99 ± 1.19Taurine10.38 ± 0.83
 Lactate0.89Glycine3.47 ± 0.75Ascorbate7.611 ± .42
 Taurine0.61Glutamate2.57 ± 0.58myo-Inositol6.33 ± 2.80
 ATP (or ADP)0.59Ascorbate2.57 ± 0.64Glutamate4.16 ± 0.97
 Ascorbate0.44Alanine2.08 ± 0.45Dopamine2.55 ± 2.04
 AMP0.30Creatine1.39 ± 0.28O-Phosphoethanolamine2.06 ± 0.25
 ADP (or ATP)0.21sn-Glycero-3-phosphocholine 1.29 ± 0.34AMP1.85 ± 1.39
 Glutamate0.17myo-Inositol1.21 ± 0.26Betaine1.83 ± 0.31
SuccinateSuccinate
 30 of 670.0130 of 670.29 ± 0.10
Catecholamine and metabolite profile (nmol/mg of tissue)
 Dopamine0.070.38 ± 0.082.55 ± 2.04
 3,4-Dihydroxybenzeneacetatea0.000.05 ± 0.020.23 ± 0.05
 Norepinephrine12.330.06 ± 0.0333.87 ± 29.41
 Normetanephrine0.000.02 ± 0.010.00 ± 0.00
 Epinephrine16.150.00 ± 0.000.81 ± 0.78
 Tyrosine0.000.11 ± 0.010.03 ± 0.00

a3,4 dihydroxyphenylacetic acid (DOPAC).

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