Nutrition, GH/IGF-1 signaling, and cancer

in Endocrine-Related Cancer
Authors:
Maura Fanti Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA

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https://orcid.org/0000-0002-8627-666X
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Valter D Longo Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA

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https://orcid.org/0000-0002-0946-7534

Correspondence should be addressed to V Longo: vlongo@usc.edu

This paper is part of a themed collection on the role of Growth Hormone in Endocrine Cancers. The Guest Editor for this collection was John Kopchick, Ohio University, USA.

DOI:
https://doi.org/10.1530/ERC-23-0048
Volume/Issue:
Volume 31: Issue 11
Article Type:
Review Article
Article ID:
e230048
Online Publication Date:
07 Oct 2024
Copyright:
© the author(s) 2024
Collections:
Growth Hormone in Endocrine Cancers
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Cancer is the second leading cause of death in the United States and among the most prevalent diseases globally, with an incidence expected to grow because of smoking, pollution, poor dietary habits, obesity, and the rise in the older population. Given their ability to reduce risk factors, albeit with varying efficacy, nutrition and fasting could help prevent cancer and other age-related disorders. Calorie restriction (CR), various forms of intermittent fasting (IF) or periodic fasting (PF), and fasting-mimicking diets (FMDs) have been shown to improve health span, increase lifespan, and prevent or postpone cancer in rodents. The effects of specific diets and fasting regimens on aging and cancer appear to be mediated in part by the reduction in the activity of the growth hormone (GH)/insulin-like-growth-factor-I (IGF-1) axis. Nevertheless, recent data indicate that the alternation of low and normal levels of these hormones and factors may be ideal for optimizing longevity and function. Here, we review the role of nutrition, CR, and fasting/FMD on cancer, focusing on the hypothesis that the modulation of GH, IGF-1, and insulin signaling partly mediates the effect of these dietary interventions on cancer prevention.

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Print ISSN:
1351-0088
Online ISSN:
1479-6821
Copyright:
© the author(s) 2024
Article ID:
e230048
Received Date:
21 Feb 2023
Accepted Date:
20 Aug 2024
Print Publication Date:
01 Nov 2024
Online Publication Date:
07 Oct 2024

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