Themed Collection: Advances and future directions in pheochromocytoma and paraganglioma

Endocrine-Related Cancer is pleased to announce a themed collection entitled Advances and future directions in pheochromocytoma and paraganglioma.

Research on pheochromocytoma and paraganglioma has made remarkable progress over the past 20 years. Researchers and clinicians unraveled the genetic complexity of this disease, demonstrated the important contribution of susceptibility genes to tumor pathophysiology, and identified somatic or circulating biomarkers for better patient management. Experimental models have been generated to promote mechanistic research and test innovative therapeutic approaches and numerous clinical trials are underway. In the steps of the 6th International symposium on Pheochromocytoma and Paraganglioma, this collection will highlight the most recent advances and perspectives of the field, with renown experts commenting on the latest research related to genetics, metabolomics, nuclear medicine, preclinical models, and mitochondrial dysfunction. Several other current topics will also be addressed.

Articles published within the special collection:

International Symposium on Pheochromocytoma: An event of dedicated healthcare professionals and researchers striving for better patient outcomes
Karel Pacak and Roderick J Clifton-Bligh

Update on the genetics of paragangliomas
Anne-Paule Gimenez-Roqueplo, Mercedes Robledo, and Patricia L M Dahia

Metabolomics in paraganglioma: applications and perspectives from genetics to therapy
Susan Richter, Timothy J Garrett, Nicole Bechmann, Roderick J Clifton-Bligh, and Hans K Ghayee

Nuclear medicine in pheochromocytoma and paraganglioma: at a crossroads with precision medicine
David Taïeb, Christelle Fargette, Abhishek Jha, and Karel Pacak

Progress and challenges in experimental models for pheochromocytoma and paraganglioma
Arthur S Tischler and Judith Favier

Pacak–Zhuang syndrome: a model providing new insights into tumor syndromes
Jared S Rosenblum, Herui Wang, Matthew A Nazari, Zhengping Zhuang and Karel Pacak

Distortion in transmission of pathogenic SDHB- and SDHD-mutated alleles from parent to offspring
Dahlia F Davidoff, Eugenie S Lim, Diana E Benn, Yuvanaa Subramaniam, Eleanor Dorman, John R Burgess, Scott A Akker, and Roderick J Clifton-Bligh

Risk of complications after core needle biopsy in pheochromocytoma/paraganglioma
Liang Zhang, Tobias Åkerström, Kazhan Mollazadegan, Felix Beuschlein, Karel Pacak, Britt Skogseid and Joakim Crona

False-positive results for pheochromocytoma associated with norepinephrine reuptake blockade
Robin Schürfeld, Christina Pamporaki, Mirko Peitzsch, Nada Rayes, Osama Sabri, Silvio Rohm, Ronald Biemann, Benjamin Sandner, Anke Tönjes and Graeme Eisenhofer

The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide
Francesca Amore, Rachele Garella, Alice Santi, Daniele Guasti, Serena Martinelli, Letizia Canu, Daniele Bani, Jiri Neuzil, Mario Maggi, Roberta Squecco and Elena Rapizzi

Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours
Paul Benjamin Loughrey, Federico Roncaroli, Estelle Healy, Philip Weir, Madhu Basetti, Ruth T Casey, Steven J Hunter and Márta Korbonits

Advancements and challenges in pheochromocytoma and paraganglioma research: a collection of insights
Judith Favier, Karel Pacak and Roderick Clifton-Bligh