Themed Collection: Growth Hormone in Endocrine Cancers


Endocrine-Related Cancer Growth Hormone special collection banner


Endocrine-Related Cancer is pleased to announce a themed collection entitled Growth Hormone in Endocrine Cancers. As early as the 1950 the involvement of Growth Hormone (GH) in cancer was reported and articles continue to appear in this area. More recently the GH/IGF-1 axis has become more prominent as to its role in several types of cancers. Also, compounds that inhibit IGF-1 action (specific monoclonal antibodies and intracellular signalling inhibitors) have been, or are being, evaluated in clinical trials. Recent publications suggesting inhibition of GH action alone or in combination with chemotherapies have generated impressive results related to tumour growth.

This collection will highlight the involvement of Growth Hormone in a variety of cancers, with experts commenting on the latest research related to the mechanism(s) whereby GH influences cancer growth, the combination of GH antagonists and chemotherapy in the treatment of cancer, the effect of diet on cancer, GH’s autocrine/paracrine/endocrine action and cancer, as well as several other current topics.

If you are interested in contributing an original research article to this collection, please submit your article proposal to


Articles published within the special collection:


Autocrine/paracrine growth hormone in cancer progression
Xi Zhang, Vijay Pandey, Vipul Bhardwaj, Tao Zhu, and Peter E Lobie

GH and IGF1 in cancer therapy resistance
Reetobrata Basu and John J Kopchick

Targeting growth hormone in cancer: future perspectives
Yue Wang, Stephen M F Jamieson, and Jo K Perry

Congenital IGF-1 deficiency protects from cancer: lessons from Laron syndrome
Zvi Laron and Haim Werner

The science behind the relations among cancer, height, growth patterns and growth hormone axis
Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski and Wouter W de Herder

GH-dependent growth of experimentally induced carcinomas in vivo
Paul C Marker, Christopher J Unterberger, and Steven M Swanson

Non-pituitary GH regulation of the epithelial microenvironment
Vera Chesnokova and Shlomo Melmed

Cancer in Ecuadorian subjects with Laron syndrome (ELS)
Jaime Guevara-Aguirre, Gabriela Peña, Gabriel Pazmiño, William Acosta, Jannette Saavedra, Daniela Lescano, Alexandra Guevara, and Antonio W D Gavilanes

Long term safety of growth hormone replacement therapy in survivors of cancer and tumors of the pituitary region
Melissa Bolier, Aart-Jan Van der Lelij, Geert Janssens, Marry M. van den Heuvel-Eibrink, and Sebastian J C M M Neggers

Insulin-like growth factor-1 receptor crosstalk with integrins, cadherins, and the tumor microenvironment: sticking points in understanding IGF1R function in cancer
Christopher A Galifi and Teresa L Wood

Cancer in growth hormone excess and growth hormone deficit
Jaime Guevara-Aguirre, Gabriela Peña, William Acosta, Gabriel Pazmiño, Jannette Saavedra, Lina Soto, Daniela Lescano, Alexandra Guevara, and Antonio W D Gavilanes

Growth hormone and radiation therapy: friend, foe, or both?
Verónica A Bahamondes Lorca and Shiyong Wu


Collection Editor:

photo of John Kopchick

Professor John Kopchick, Guest Editor
Edison Biotechnology Institute &
Heritage College of Medicine
Ohio University, USA