Themed Collection: 100 Years of the Warburg Effect and Endocrine Cancer


Endocrine-Related Cancer Warburg effect special collection banner


Endocrine-Related Cancer is pleased to announce a themed collection celebrating 100 Years of the Warburg Effect and Endocrine Cancer, Guest edited by Professor Lois Mulligan (Cancer Research Institute at Queen’s University, Canada) and Dr Pascale Bossard (French Institute of Health and Medical Research at the Cochin Institute, France).

This collection will highlight the involvement of the Warburg Effect in Endocrine Cancer, and how this initial observation as impacted on our understanding of cancer metabolism and ultimately treatment.

“A century ago, Otto Warburg identified one of the first hallmarks of cancer cells: the ability to rewire their metabolism to favour glycolysis even in the presence of oxygen, known as the ‘Warburg effect’. From then, biochemical studies to the more contemporary ‘omics’ approaches such as metabolomics or fluxomics, have revealed the complexity of the metabolic adaptations cancer cells must go through in order to proliferate and survive. They allowed the identification of drivers and regulators involved in these metabolic reprogramming, such as the part played by oncogenes or small non coding RNA. The Warburg effect leads to major modifications in mitochondrial metabolism but intriguingly also to changes in mitochondrial dynamics and remodelling. Overall, identifying the molecular pathways involved in these cancer cell specific features is giving very interesting hints into therapeutic strategies.”

Pascale Bossard, Guest Editor


If you are interested in contributing an original research article to this collection, please submit your article proposal to


Articles published within the special collection:


MicroRNAs as regulators of tumor metabolism
Francesca Ruggieri, Katharina Jonas, Manuela Ferracin, Michael Dengler, Vanessa Jӓger, and Martin Pichler

100 years of the Warburg effect: a historical perspective
D Grahame Hardie

Mitochondrial dynamics and oxidative phosphorylation as targets in cancer
Kaylee B Punter, Charles Chu, and Edmond Y W Chan


Collection Editors


Professor Lois Mulligan, Advisory Editor
Cancer Research Institute
Queen’s University, Canada

Pascale Bossard, Guest Editor
French Institute of Health and Medical Research
Cochin Institute, France