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Marie Colombe Agahozo Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Anieta M Sieuwerts Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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S Charlane Doebar Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Esther I Verhoef Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Corine M Beaufort Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Kirsten Ruigrok-Ritstier Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Vanja de Weerd Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Hein F B M Sleddens Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Winand N M Dinjens Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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John W M Martens Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Carolien H M van Deurzen Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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component, which could not be contributed to differences in the EPCAM , ESR1 or ERBB2 expression as quantified by RT-qPCR. Previous studies on this topic either focused on the IBC stage only or on high-grade DCIS and synchronous DCIS and IBC ( Sakr et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0019
Volume/Issue:
Volume 26: Issue 5
Free access
Stefano Mangiola Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Division of Bioinformatics, Walter and Eliza Hall Institute, Parkville, Victoria, Australia

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Ryan Stuchbery Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Geoff Macintyre Centre for Neural Engineering, Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
Diagnostic Genomics, NICTA, Victoria Research Laboratory, The University of Melbourne, Parkville, Victoria, Australia

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Michael J Clarkson Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Justin S Peters Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Anthony J Costello Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Christopher M Hovens Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Niall M Corcoran Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia

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). Data were filtered, normalised and tested for global differential expression accounting for unwanted variation as described earlier for our RNA-seq data set. The 14 genes analysed with qRT-PCR were employed to classify low-/high-grade patients in a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0058
Volume/Issue:
Volume 25: Issue 5
Free access
Neetu Dahiya Laboratory of Cellular and Molecular Biology, Department of Pathology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, Maryland 21224, USA

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Patrice J Morin Laboratory of Cellular and Molecular Biology, Department of Pathology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, Maryland 21224, USA
Laboratory of Cellular and Molecular Biology, Department of Pathology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, Maryland 21224, USA

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versus late-stage cancer Zhang et al . (2008)  None miR-514 , miR-509 , miR-508 , miR-34c , miR-513 , miR-368 , miR-379 , miR-154 , miR-337 , miR-507 , miR-503 , miR-376 Low-grade cancer versus high-grade cancer Zhang et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0203
Volume/Issue:
Volume 17: Issue 1
Free access
Emma Samuelson Department of Medical and Clinical Genetics, Department of Cell and Molecular Biology, Department of Mathematical Statistics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska Academy, SE 40530 Gothenburg, Sweden
Department of Medical and Clinical Genetics, Department of Cell and Molecular Biology, Department of Mathematical Statistics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska Academy, SE 40530 Gothenburg, Sweden

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Carola Hedberg Department of Medical and Clinical Genetics, Department of Cell and Molecular Biology, Department of Mathematical Statistics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska Academy, SE 40530 Gothenburg, Sweden
Department of Medical and Clinical Genetics, Department of Cell and Molecular Biology, Department of Mathematical Statistics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska Academy, SE 40530 Gothenburg, Sweden

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Staffan Nilsson Department of Medical and Clinical Genetics, Department of Cell and Molecular Biology, Department of Mathematical Statistics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska Academy, SE 40530 Gothenburg, Sweden

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Afrouz Behboudi Department of Medical and Clinical Genetics, Department of Cell and Molecular Biology, Department of Mathematical Statistics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska Academy, SE 40530 Gothenburg, Sweden

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mainly found in high-grade tumors; Salvesen et al . 2000 ). P16 inactivation correlates with K-RAS mutations, high stage and high grading of tumors as well as poor survival ( Salvesen et al . 2005 ). We found significant low expression level (28

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0185
Volume/Issue:
Volume 16: Issue 1
Free access
Clovis Boibessot Department of Surgery, Laval University, Quebec City, Quebec, Canada

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Paul Toren Department of Surgery, Laval University, Quebec City, Quebec, Canada

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homeostasis by prostate size are interesting to PCa progression given that smaller prostate size is known to be an independent predictor of high-grade PCa ( Newton et al. 2010 ). Relationship between serum and prostate tissue sex steroid levels The

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0493
Volume/Issue:
Volume 25: Issue 3
Free access
Carmine Valenza Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy

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Francesca Spada Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Francesco Multinu Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Lavinia Benini Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Michele Borghesani Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Laura Algeri Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Manila Rubino Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Eleonora Pisa Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Lorenzo Gervaso Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Chiara Alessandra Cella Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Silvestro Carinelli Division of Pathology and Laboratory Medicine, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Simone Bruni Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Gabriella Schivardi Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Giuseppe Curigliano Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy

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Vanna Zanagnolo Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Giovanni Aletti Department of Oncology and Hemato-Oncology (DIPO), University of Milan, Milan, Italy
Division of Gynecologic Surgery, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy

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Nicoletta Colombo Division of Gynecologic Oncology, European Institute of Oncology, IRCCS, Via Ripamonti, Milan, Italy
Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

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Nicola Fazio Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Via Ripamonti, Milan, Italy

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Introduction High-grade neuroendocrine carcinoma of the cervix (NECC) is a rare subtype of invasive cervical carcinoma, accounting for 1.4% of all cases of cervical carcinoma and displaying an extremely aggressive biological behavior, with a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0112
Volume/Issue:
Volume 30: Issue 10
Restricted access
Vinciane Corman Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Iulia Potorac Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Florence Manto Faculty of Medicine, Université de Liège, Liège, Belgium

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Sarah Dassy Department of Oncology, St Nikolaus-Hospital, Eupen, Belgium

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Karin Segers Department of Human Genetics, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Albert Thiry Department of Anatomo-pathology, Centre Hospitalier Universitaire de Liège, Université de Liège, Liège, Belgium

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Vincent Bours Department of Human Genetics, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire de Liege, Université de Liège, Liège, Belgium

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diameter. The lesion was judged suspicious and micro-biopsies were performed. The histological analysis of the region with micro-calcifications revealed a high-grade ductal in situ carcinoma (DIN 3) without obvious signs of infiltration. The histology of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0057
Volume/Issue:
Volume 23: Issue 5
Free access
Habibur P Rahman Institute of Metabolism and Systems Research, University of Birmingham, Birmingham

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Johannes Hofland Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Paul A Foster Institute of Metabolism and Systems Research, University of Birmingham, Birmingham
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Healthcare Partners, Birmingham, UK

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1991 and 2012 in their review and conclude obesity is associated with aggressive prostate cancer ( Allott et al . 2013 ). There is further robust evidence that obese patients are more likely to present with aggressive high-grade prostate cancer ( De

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0118
Volume/Issue:
Volume 23: Issue 6
Restricted access
Atsuko Kasajima Department of Pathology, Technical University Munich, Munich, Germany
Member of the German Cancer Consortium (DKTK), Germany

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Günter Klöppel Department of Pathology, Technical University Munich, Munich, Germany

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. 2012 ; j Konukiewitz et al. 2018 ; k Konukiewitz et al. 2017 ; l Associated with high grade tumor; m A higher prevalence of TP53/Rb1 biallelic mutation in small cell lung carcinoma than in large cell neuroendocrine carcinoma (LCNEC); n

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0122
Volume/Issue:
Volume 27: Issue 11
Free access
Günter Klöppel Department of Pathology, Technical University of München, Ismaninger Strasse 22, 81675 München, Germany

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behaviour and well-differentiated endocrine carcinomas with low-grade malignant behaviour and 3) poorly differentiated endocrine carcinomas with high-grade malignant behaviour. Table 1 Comparison of the 2010 WHO classification for gastroenteropancreatic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0013
Volume/Issue:
Volume 18: Issue S1
Free access