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Molecular Medicine Program, University of Pavia, Pavia, Italy
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be different, ranging from very fast progressing, as it is for patients with a poorly differentiated neuroendocrine carcinoma (NEC) to quite indolent, as in most patients with well-differentiated metastatic small bowel neuroendocrine tumor (NET). Most
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
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University of Bergen, Deptartment of Clinical Medicine, Bergen, Norway
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Department of Surgery, Ryhov County Hospital, Jönköping, Sweden
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Fave G Öberg K 2007 Interferon-α and somatostatin analog in patients with gastroenteropancreatic neuroendocrine carcinoma: single agent or combination? Annals of Oncology 18 13 – 19 . ( https://doi.org/10.1093/annonc/mdl144 ) Ferolla P Faggiano
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A, Nicklee T, Ho J et al. 2006 A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. British Journal of Cancer 95 1148 –1154. Engstrom P , Lavin P
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tumors were well-differentiated neuroendocrine carcinomas. Endocrine tumors have often been treated as a homogenous group in the literature, but resent research has stated their heterogeneity; thus, pancreatic neuroendocrine tumors are foregut and not
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Department of Gynecology, Department of Biostatistics, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Pathology, Department of Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai 200011, China
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Department of Gynecology, Department of Biostatistics, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Pathology, Department of Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai 200011, China
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Department of Gynecology, Department of Biostatistics, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Pathology, Department of Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai 200011, China
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Department of Gynecology, Department of Biostatistics, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Pathology, Department of Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai 200011, China
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Nakajima T 2009 High-grade neuroendocrine carcinoma of the lung: comparative clinicopathological study of large cell neuroendocrine carcinoma and small cell lung carcinoma . Pathology International 59 522 – 529 . ( doi:10.1111/j.1440
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et al. 2019 ). NET biology is defined by grade and differentiation, with well-differentiated (WD) NETs typically demonstrating more indolent disease biology compared to poorly differentiated neuroendocrine carcinomas ( Cambiaghi et al. 2017
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Department of Oncogenetics, A.C. Camargo Cancer Center, São Paulo, Brazil
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National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation (INCITO-INOTE), São Paulo, Brazil
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National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation (INCITO-INOTE), São Paulo, Brazil
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Introduction Neuroendocrine neoplasms (NENs), including well-differentiated neuroendocrine tumours (NETs) and poorly differentiated neuroendocrine carcinomas (NECs), comprise an infrequent group of cancers with heterogeneous behaviour and
Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
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Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
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Institute of Pathology, Department of Internal Medicine, Department of Pathology, Institute of Pathology, Institute of Pathology, Institute of Pathology, Charité Universitätsmedizin, Berlin, Germany
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proved to be effective in the first place, especially in pancreatic neuroendocrine carcinomas. Tissue-based predictive biomarkers for response to everolimus are currently lacking. However, expression of mTOR pathway components has been suggested as a
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( Fenton et al . 2001 ). Also, Cameselle-Teijeiro and coworkers presented a 42-year-old man with known FAP having a CMV-PTC associated with neuroendocrine carcinoma component. The patient died with lung and brain metastases ( Cameselle-Teijeiro et al
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-differentiated neuroendocrine carcinoma (NEC), either functioning or nonfunctioning and the combination cisplatin/etoposide is the most popular ( Baudin et al. 2013 ). Overall, 5-fluorouracil (5-FU), doxorubicin, and streptozotocin have been commonly used in the treatment of