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Hao Fu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Lin Cheng Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Yuchen Jin Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Libo Chen Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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.23.1.0455 ) 10.1210/edrv.23.1.0455 11844744 Biyi A Zaimi S Doudouh A 2016 Functioning metastases from thyroid papillary carcinoma in bone . Journal of Nuclear Medicine Technology 44 253 – 254 . ( https://doi.org/10.2967/jnmt.116

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M Bullock Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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C O'Neill Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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A Chou Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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A Clarkson Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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T Dodds Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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C Toon Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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M Sywak Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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S B Sidhu Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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L W Delbridge Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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B G Robinson Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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D L Learoyd Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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D Capper Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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A von Deimling Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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R J Clifton-Bligh Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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A J Gill Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and
Hormones and Cancer Group, Department of Endocrine Surgery, Department of Anatomical Pathology, Endocrinology, Department of Neuropathology, Clinical Cooperation Unit Neuropathology, Northern Cancer Translational Research Unit, University of Sydney, Cancer Genetics Laboratory, Kolling Institute of Medical Research and

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Surgical Pathology 36 844 – 850 . ( doi:10.1097/PAS.0b013e318246b527 ). Lee JH Lee ES Kim YS 2007 Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis . Cancer 110 38 – 46 . ( doi

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Paraskevi Xekouki Section on Endocrinology and Genetics (SEGEN), Program on Developmental Endocrinology and Genetics (PDEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Inter-Institute Pediatric Endocrinology Program, National Institutes of Health (NIH), Building 10, CRC, Room 1-3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA

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Constantine A Stratakis Section on Endocrinology and Genetics (SEGEN), Program on Developmental Endocrinology and Genetics (PDEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Inter-Institute Pediatric Endocrinology Program, National Institutes of Health (NIH), Building 10, CRC, Room 1-3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA

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Manger et al . (1977) 15/F Acromegaly/PHEO – b NA Melicow (1977) 52/F Chromophobe adenoma of pituitary/papillary carcinoma of thyroid/PHEO diagnosed postmortem – b NA Janson et al . (1978) 28/F Pituitary adenoma (probably nonfunctioning)/bilateral PHEO

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Valdemar Máximo Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Jorge Lima Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Hugo Prazeres Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Paula Soares Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Manuel Sobrinho-Simões Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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cell lines . Oncogene 24 1455 – 1460 . doi:10.1038/sj.onc.1208292 . Albores-Saavedra J 2010 Papillary thyroid carcinoma with prominent hobnail features: a new aggressive variant of moderately differentiated papillary carcinoma. A

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Thomas J Giordano Divisions of Anatomic Pathology and Molecular & Genomic Pathology, Departments of Pathology and Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA

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). (A) Ranking of papillary carcinoma according to the BRS. (B) Driver mutational status. (C) Thyroid differentiation score. (D) Genomic platform clusters. (E) Histologic type and follicular fraction. Reproduced, with permission, from Cancer Genome

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Mabel Ryder Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine

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Ronald A Ghossein Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine

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Julio C M Ricarte-Filho Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine

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Jeffrey A Knauf Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine

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James A Fagin Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine
Endocrinology Service, Human Oncology and Pathogenesis Program, Department of Pathology, Department of Medicine

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-differentiated papillary carcinoma, follicular variant. (B) High power of (A) (arrow indicates isolated TAM). (C) Moderate density of CD68 + TAM in poorly differentiated thyroid carcinomas. (D) High power of (C) (arrow indicates TAM). (E) Very high density of CD68 + TAM

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Roland Pfoh Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

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Ira Kay Lacdao Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

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Vivian Saridakis Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

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), oral squamous cell carcinoma ( Piao et al . 2012 ), and papillary carcinoma ( Wang et al . 2013 ). The overexpression of USP22 is related to poor prognosis and may be used as a biomarker during diagnosis. USP22 has been identified as a cancer stem

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Tirtha K Das Department of Cell, Developmental and Regenerative Biology, School of Biomedical Sciences, Icahn School of Medicine, New York, New York, USA

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Ross L Cagan Department of Cell, Developmental and Regenerative Biology, School of Biomedical Sciences, Icahn School of Medicine, New York, New York, USA

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Porta G Fusco A Vecchio G 1990 PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas . Cell 60 557 – 563 . ( https://doi.org/10.1016/0092-8674(90)90659-3 ) Haffter P

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M M Muresan Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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P Olivier Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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J Leclère Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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F Sirveaux Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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L Brunaud Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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M Klein Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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R Zarnegar Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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G Weryha Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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scientific work. References Aasland R Akslen LA Varhaug JE Lillehaug JR 1990 Co-expression of the genes encoding transforming growth factor-alpha and its receptor in papillary carcinomas of the thyroid . International Journal of Cancer 46 382 – 387

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Gennaro Chiappetta
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Carmela De Marco
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Giuseppe Viglietto
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, normal thyroid cell line (P5); NPA, BHP2.7, BHP10.3, TPC-1, BHP17.10 and B-CPAP cell lines were derived from papillary carcinomas (PTCs), WRO from follicular carcinoma (FTC), FB-1, ARO and FRO cells were derived from ATC. Antibodies to β-tubulin were used

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