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Lucas Leite Cunha Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo, Brazil

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Marjory Alana Marcello Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo, Brazil

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Laura Sterian Ward Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo, Brazil

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progression, as not only the classically studied pathways, such as PI3K/AKT and MAPK, appear to be involved in malignant TGFβ transformation, but also SMAD molecules might play a role in this event. Interleukins A large group of secreted proteins that bind to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0431
Volume/Issue:
Volume 21: Issue 3
Free access
Xuan Chen Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Sixuan Liu Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xue Peng Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xiangyun Zong Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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receptor complex with AMHRI. This complex phosphorylates AMHRI and activates serine/threonine protein kinase. Subsequently, intracellular Smad-proteins (R-SMads1/5/8) detach from the receptor complexes, allowing several proteins to enter the nucleus to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0060
Volume/Issue:
Volume 30: Issue 10
Open access
Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Kate E Lines Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Shani Avniel-Polak Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

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Chas Bountra Structural Genomics Consortium, University of Oxford, Oxford, UK

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Rajesh V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Oxford, UK

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)-1 and -2-containing complexes and Smad3 (a TGF-β signalling component) to promote transcription of target genes; it restricts Wnt pathway target genes transcription by blocking β-catenin from entering the nucleus; in the cytoplasm, menin binds to Akt

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0127
Volume/Issue:
Volume 27: Issue 9
Free access
Yu-Xia Chen
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Yan Wang
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Chen-Chun Fu
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Fei Diao
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Liang-Nian Song Department of Pathophysiology, Department of Medicine, the Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China

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Zong-Bin Li
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Rui Yang
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Jian Lu
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. Therefore, in the present study, we investigated the effect of Dex on cell adhesion to ECM of two human ovarian cancer cell lines, HO-8910 and SKOV3, and examined the relationship between Dex's effect of enhancing adhesion and Dex-induced cell resistance to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0296
Volume/Issue:
Volume 17: Issue 1
Free access
C R C Pieterman Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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E B Conemans Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands
Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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K M A Dreijerink Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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J M de Laat Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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H Th M Timmers Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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M R Vriens Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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G D Valk Division of Internal Medicine and Dermatology, Division of Biomedical Genetics, Division of Surgical Specialties, Department of Internal Medicine, University Medical Center Utrecht, Internal post number L.00.408, PO Box 85500, 3508 GA Utrecht, The Netherlands

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) Overexpressed Kaji et al . (2001) Menin–SMAD3 Cos7 (monkey kidney) Overexpressed Heppner et al . (2001) Menin–NFκB 293 (human embryonic kidney) Endogenous, overexpressed Sierra et al . (2006) Menin–β-catenin CRC (human colorectal cancer) Endogenous Dreijerink

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0482
Volume/Issue:
Volume 21: Issue 3
Free access
Debbie Clements
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Sarah L Asprey
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Thomas A McCulloch Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

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Theresa A Morris Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

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Susan A Watson Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

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Simon R Johnson
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bovine serum (FBS). Primary cells were cultured from angiomyolipoma resections performed for therapeutic purposes. Excess material not required for clinical use was divided into small (∼3×3×3 mm) fragments, treated with type II collagenase and the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0123
Volume/Issue:
Volume 16: Issue 1
Free access
Anela Blažević Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Anand M Iyer Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Marie-Louise F van Velthuysen Department of Pathology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Johannes Hofland Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Gaston J H Franssen Department of Surgery, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Richard A Feelders Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Marina Zajec Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Theo M Luider Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Wouter W de Herder Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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Leo J Hofland Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, The Netherlands

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suppresses TGFβ1‑induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway . Molecular Medicine Reports 18 3907 – 3913 . ( https://doi.org/10.3892/mmr.2018

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0237
Volume/Issue:
Volume 30: Issue 6
Restricted access
S Fontanière
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J Tost
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A Wierinckx
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J Lachuer
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J Lu
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N Hussein
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F Busato
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I Gut
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Z-Q Wang
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C-X Zhang
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and cell death induced by certain growth factors. We have also checked the expression of proteins known to interact with menin in our tumour samples, such as JunD, Smad3 and NFκB factors, and none of these factors showed altered transcriptional

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01294
Volume/Issue:
Volume 13: Issue 4
Free access
Faith Nutter Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Ingunn Holen Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Hannah K Brown Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Simon S Cross Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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C Alyson Evans Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Matthew Walker Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Robert E Coleman Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Jules A Westbrook Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Peter J Selby Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Janet E Brown Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre
Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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Penelope D Ottewell Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

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the first tumour reached 1 cm 3 . Microcomputed tomography imaging Analysis of bone volume was carried out using a Skyscan 1172 X-ray-computed microtomograph (Skyscan, Aartselaar, Belgium). Pixel size was set to 4.37 μm and scanning was initiated from

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0158
Volume/Issue:
Volume 21: Issue 2
Free access
Tsai-Der Chuang Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610-0294, USA

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Harekrushna Panda Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610-0294, USA

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Xiaoping Luo Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610-0294, USA

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Nasser Chegini Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610-0294, USA

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regulatory function of microRNAs (miRNAs) on protein-coding gene expression through interacting with their 3′ UTR resulting in their posttranscriptional repression ( Djuranovic et al . 2011 ). Through this mechanism, miRNAs regulate various aspects of normal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0007
Volume/Issue:
Volume 19: Issue 4
Open access
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