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Suzanne M Johnson MRC Molecular Endocrinology Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK

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Manijeh Maleki-Dizaji MRC Molecular Endocrinology Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK

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Jerry A Styles MRC Molecular Endocrinology Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK

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Ian N H White MRC Molecular Endocrinology Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK

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shown that oestradiol (E 2 ) and related SERMs differentially regulate target gene expression via ERα or ERβ ( Kian et al. 2004 , Stossi et al. 2004 , Monroe et al. 2005 ). Recently, it has been demonstrated, in various human cell types

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0085
Volume/Issue:
Volume 14: Issue 2
Free access
Douglas A Gibson Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Frances Collins Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Fiona L Cousins Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Arantza Esnal Zufiaurre Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Philippa T K Saunders Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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endothelial cell migration and re-endothelialisation ( Umetani et al . 2007 ). In contrast, in the absence of E2, 27HC is reported to act as an agonist to ERα (ESR1) to increase cell adhesion and expression of pro-inflammatory cytokines such as tumour

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0449
Volume/Issue:
Volume 25: Issue 4
Open access
Razan Abou Ziki Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Romain Teinturier Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Yakun Luo Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Catherine Cerutti Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France

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Jean-Marc Vanacker Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France

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Coralie Poulard Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Thomas Bachelot Department of Medical Oncology, Centre Léon Bérard, Lyon, France

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Mona Diab-Assaf Faculty of Sciences II, Lebanese University Fanar, Beirut, Lebanon

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Isabelle Treilleux Département de Biopathologie, Centre Léon Bérard, Lyon, France

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Chang Xian Zhang Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Muriel Le Romancer Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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-enriched and triple negative BC (TNBC). Luminal A and B subtypes, representing around 40 and 20% of BC, respectively, express ERα. The HER2-enriched subtype behaves more aggressively than luminal subtypes but is sensitive to therapies targeting the HER2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0337
Volume/Issue:
Volume 29: Issue 8
Restricted access
Nikki A Ford Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Nomeli P Nunez Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Valerie B Holcomb Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Stephen D Hursting Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA
Department of Nutritional Sciences, Department of Molecular Carcinogenesis, Dell Pediatric Research Institute, University of Texas, 1400 Barbara Jordan Boulevard, DPRI 2.834, Austin, Texas 78722, USA

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Introduction The prevalence of obesity, an established risk and progression factor for estrogen receptor α (ERα)-positive luminal A breast cancer, has dramatically increased in the USA and many other parts of the world over the past 25 years

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0329
Volume/Issue:
Volume 20: Issue 1
Free access
Haojun Luo
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Guanglun Yang Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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Tenghua Yu Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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Shujuan Luo Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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Chengyi Wu Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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Yan Sun Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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Manran Liu Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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Gang Tu Department of Breast and Thyroid Surgery, Department of Endocrine and Breast Surgery, Department of Gynecology and Obstetrics, Key Laboratory of Laboratory Medical Diagnostics, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

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are recognized as co-mediators of tumor progression rather than as merely bystanders. Estrogen is well recognized as a mitogen for breast cancer cells. Traditionally, estrogenic effects have been ascribed to the nuclear estrogen receptors (ERα and ERβ

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0237
Volume/Issue:
Volume 21: Issue 2
Open access
J Yang Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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Y-L Zhao Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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Z-Q Wu Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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Y-L Si Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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Y-G Meng Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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X-B Fu Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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Y-M Mu Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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W-D Han Department of Molecular Biology, Department of Endocrinology, Institute of Basic Medicine

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(ERα) and amplifies the receptor's transactivation ( Han et al . 2007 ). The LRP16 gene was originally isolated from human lymphocyte cells and predominantly localizes in the nucleus ( Han et al . 2001 , 2002 ). Although the expression pattern of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0150
Volume/Issue:
Volume 16: Issue 1
Free access
Chunyan Hu The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Manli Wang The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Miao Hu The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Shanshan Ma The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Bingmo Yang The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Wei Xiao The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Qian Zhou The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Ming Zhou The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Zhong Li The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Introduction Approximately 70% of breast cancers express estrogen receptor α (ERα) and require endocrine therapies, such as the ER antagonist, tamoxifen (TAM) ( EBCTCG. 2005 ). However, ER-positive breast cancer frequently acquires resistance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0191
Volume/Issue:
Volume 30: Issue 2
Restricted access
Anthony Howell CRUK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK

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are mediated by two subtypes of ER, ERα and ERβ. Both receptors belong to a family of ligand-activated nuclear transcription factors ( Evans 1988 ) and share a high degree of homology in their DNA binding domains ( Kuiper et al. 1996 ). However, they

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.00846
Volume/Issue:
Volume 13: Issue 3
Free access
Elizabeth W LaPensee Department of Cancer and Cell Biology, University of Cincinnati, 3125 Eden Avenue, Cincinnati, Ohio 45267-0521, USA

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Nira Ben-Jonathan Department of Cancer and Cell Biology, University of Cincinnati, 3125 Eden Avenue, Cincinnati, Ohio 45267-0521, USA

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classical (ERα and ERβ) and nonclassical (G protein-coupled receptor 30, GPR30) receptors ( Manavathi & Kumar 2006 ), there is only one receptor (PRLR) for PRL, albeit it exists in several isoforms which couple to different signaling pathways ( Swaminathan

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0253
Volume/Issue:
Volume 17: Issue 2
Free access
Zane Hammoud Department of Obstetrics and Gynecology, Thoracic Surgery, Pathology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, Indiana 46202-5121, USA Departments of

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Bailin Tan
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Sunil Badve Department of Obstetrics and Gynecology, Thoracic Surgery, Pathology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, Indiana 46202-5121, USA Departments of

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Robert M Bigsby
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Signaling, Danvers, MA, USA). Ovaries were also collected and homogenized; ovarian lysate served as a positive control for both ERα and ERβ. After centrifugation, the solubilized proteins were separated by 12% SDS-PAGE and blotted onto nitrocellulose

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0002
Volume/Issue:
Volume 15: Issue 2
Free access