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Susan J Hsiao Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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Yuri E Nikiforov Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA

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who present with higher-stage disease or distant metastases and patients with poorly differentiated or anaplastic thyroid cancer have higher mortality rates ( Volante et al . 2004 , Tanaka et al . 2011 ). Accurate identification of subsets of

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Livia Lamartina Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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Giorgio Grani Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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Emanuela Arvat Dipartimento di Scienze Mediche, Università di Torino, Torino, Italy

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Alice Nervo Dipartimento di Scienze Mediche, Università di Torino, Torino, Italy

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Maria Chiara Zatelli Unità Operativa di Endocrinologia e Malattie del Ricambio, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy

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Roberta Rossi Unità Operativa di Endocrinologia e Malattie del Ricambio, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy

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Efisio Puxeddu Dipartimento di Medicina, Università di Perugia, Perugia, Italy

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Silvia Morelli Dipartimento di Medicina, Università di Perugia, Perugia, Italy

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Massimo Torlontano Dipartimento di Scienze Mediche, Ospedale Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo, Italy

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Michela Massa Dipartimento di Scienze Mediche, Ospedale Casa Sollievo della Sofferenza-IRCCS, San Giovanni Rotondo, Italy

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Rocco Bellantone Cattedra di Chirurgia Endocrina, Area di Endocrinologia e Malattie Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy

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Alfredo Pontecorvi Cattedra di Endocrinologia, Area di Endocrinologia e Malattie Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy

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Teresa Montesano Unità di Medicina Nucleare, Università di Roma Sapienza, Roma, Italy

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Loredana Pagano Unità di Endocrinologia, Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, Novara, Italy

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Lorenzo Daniele Unità di Patologia, Ospedale Mauriziano Umberto I di Torino, Torino, Italy

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Laura Fugazzola Divisione di Malattie Endocrine e Metaboliche, Istituto Auxologico Italiano IRCCS, Milano, Italy
Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy

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Graziano Ceresini Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy

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Rocco Bruno Unità di Endocrinologia, Ospedale di Tinchi-Pisticci, Matera, Italy

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Ruth Rossetto Divisione di Endocrinologia, Diabetologia e Metabolismo, Dipartimento di Scienze Mediche, Ospedale Molinette, A.O.U. Città della Salute e della Scienza di Torino, Università di Torino, Torino, Italy

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Salvatore Tumino Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, Catania, Italy

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Marco Centanni Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Università di Roma Sapienza, Latina, Italia

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Domenico Meringolo Unità Operativa Semplice Dipartimentale, Ospedale Bentivoglio, Ausl Bologna, Bologna, Italy

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Maria Grazia Castagna Dipartimento di Scienze Mediche, Chirurgiche e Neurologiche, Università di Siena, Siena, Italy

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Domenico Salvatore Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli ‘Federico II’, Napoli, Italy

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Antonio Nicolucci Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy

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Giuseppe Lucisano Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy

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Sebastiano Filetti Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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Cosimo Durante Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza, Roma, Italy

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://doi.org/10.1089/thy.2015.0508 ) 26953223 10.1089/thy.2015.0508 Tuttle RM Haugen B Perrier ND 2017a Updated American Joint Committee on cancer/tumor-node-metastasis staging system for differentiated and anaplastic thyroid cancer (eighth edition): what

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Sunmi Park Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Mark C Willingham Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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Jun Qi Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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Sheue-Yann Cheng Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

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anaplastic thyroid cancer (ATC, Thrb PV/PV Kras G12D mice). In Thrb PV/PV Kras G12D mice, JQ1 suppresses the cMyc transcription via interference with BRD4 functions to block cMyc tumor-promoting activity ( Zhu et al . 2017

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Sathya Neelature Sriramareddy Molecular and Cellular Epigenetics (GIGA), University of Liege, Liège, Belgium
Molecular Biology (TERRA), University of Liege, Gembloux, Belgium

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Etienne Hamoir Endocrinology, University Hospital, Liège, Belgium

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Marcela Chavez Clinical Hematology, University Hospital, Liège, Belgium

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Renaud Louis Pneumology, University Hospital, Liège, Belgium

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Albert Beckers Endocrinology, University Hospital, Liège, Belgium

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Luc Willems Molecular and Cellular Epigenetics (GIGA), University of Liege, Liège, Belgium
Molecular Biology (TERRA), University of Liege, Gembloux, Belgium

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calcitonin. Incidence of thyroid cancer significantly increased in the past several decades ( Kuo et al. 2016 ). Tumors most frequently arise from follicular epithelial cells to generate papillary, follicular or anaplastic thyroid cancers. Medullary

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Avaniyapuram Kannan Murugan Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal, Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Abeer Al-Amr Department of Microbiology, College of Science, Female Campus, King Saud University, Riyadh, Saudi Arabia

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Mysoon M Al-Ansari Department of Microbiology, College of Science, Female Campus, King Saud University, Riyadh, Saudi Arabia
Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Pulicat S Manogaran Department of Stem Cell Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Hindi Al-Hindi Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Ali S Alzahrani Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal, Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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/PTC rearrangements, mutations in BRAF , NRAS , etc., and the PI3K/AKT pathway is activated mostly in poorly differentiated (PDTC) and anaplastic thyroid cancer (ATC) as a result of mutations in ALK , RAS , PIK3CA , AKT , etc. ( Murugan & Xing 2011 , Xing 2013

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Gustavo Penna Department of Clinical Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil

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Ileana G S Rubio Department of Biological Science, Molecular Thyroid Science Laboratory, Federal University of São Paulo, São Paulo, Brazil
Biotechnology Post-graduation Program, Federal University of São Paulo, São Paulo, Brazil
Estructural and Functional Biology Program, Federal University of São Paulo, São Paulo, Brazil

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Ester Saraiva Brust Department of Biological Science, Molecular Thyroid Science Laboratory, Federal University of São Paulo, São Paulo, Brazil
Biotechnology Post-graduation Program, Federal University of São Paulo, São Paulo, Brazil

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Juliana Cazarin Laboratory of Endocrine Physiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Fabio Hecht Laboratory of Endocrine Physiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Nina Ramalho Alkmim Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil
Post-Graduation Program Molecular Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil

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Kamilla M A Brandão Rajão Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil
Endocrinology Service of Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil

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Helton Estrela Ramos Department of Bioregulation, Health & Science Institute, Thyroid Study Laboratory, Federal University of Bahia, Salvador, Brazil
Post-Graduation Program Medicine and Health, Faculty of Medical Sciences, Federal University of Bahia, Salvador, Bahia, Brazil
Post-Graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Bahia, Brazil

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reported ( Hishinuma et al. 2005 ), including in association with an anaplastic thyroid cancer ( Yoon 2020 ). Homozygous deletion in the NIS protein associated with ITD was reported in a DTC patient who harbored a DHG with a late diagnosis, low

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Lidong Wang Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Hao Tan Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Yonglian Huang Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Mingyue Guo Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Yanxu Dong Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Chenxi Liu Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Huai Zhao Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Zhen Liu Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Dogan S Ricarte-Filho JC Krishnamoorthy GP Xu B 2016 Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers . Journal of Clinical Investigation 126 1052 – 1066 . ( https://doi.org/10.1172/JCI85271 ) Liu

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Hannah Nieto Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Kristien Boelaert Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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). Anaplastic thyroid cancers represent extreme forms of dedifferentiated tumours, and these tumours are characteristically very difficult to treat due to the lack of expression of proteins involved in the thyroid machinery. Expression of the sodium iodide

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Luca Varinelli Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Dario Caccia Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Chiara C Volpi Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Claudio Caccia Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Maida De Bortoli Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Elena Taverna Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Ambra V Gualeni Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Valerio Leoni Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Annunziata Gloghini Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Giacomo Manenti Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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Italia Bongarzone Proteomics Laboratory, Department of Diagnostic Pathology and Laboratory Medicine, Department of Predictive and Preventive Medicine, Laboratory of Clinical Pathology and Medical Genetics, Department of Experimental Oncology and Molecular Medicine

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current available therapies. Treatments for advanced thyroid cancer will require more insight into thyroid carcinogenesis ( Kojic et al . 2011 ). In this study, we show the elevated expression of MIF and CD74 in papillary and anaplastic thyroid cancer

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Christopher W Rowe Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Jonathan W Paul School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Craig Gedye Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Medical Oncology, Calvary Mater Newcastle, Waratah, Australia
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia

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Jorge M Tolosa School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Cino Bendinelli School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Department of Surgery, John Hunter Hospital, Newcastle, Australia

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Shaun McGrath Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

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Roger Smith Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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represent anaplastic thyroid cancers than DTC ( Meireles et al. 2007 , van Staveren et al. 2007 , Pilli et al. 2009 ). This is particularly true of TSHR expression, which is downregulated early in monolayer culture due to disruption of follicular

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