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who present with higher-stage disease or distant metastases and patients with poorly differentiated or anaplastic thyroid cancer have higher mortality rates ( Volante et al . 2004 , Tanaka et al . 2011 ). Accurate identification of subsets of
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Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy
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://doi.org/10.1089/thy.2015.0508 ) 26953223 10.1089/thy.2015.0508 Tuttle RM Haugen B Perrier ND 2017a Updated American Joint Committee on cancer/tumor-node-metastasis staging system for differentiated and anaplastic thyroid cancer (eighth edition): what
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anaplastic thyroid cancer (ATC, Thrb PV/PV Kras G12D mice). In Thrb PV/PV Kras G12D mice, JQ1 suppresses the cMyc transcription via interference with BRD4 functions to block cMyc tumor-promoting activity ( Zhu et al . 2017
Molecular Biology (TERRA), University of Liege, Gembloux, Belgium
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Molecular Biology (TERRA), University of Liege, Gembloux, Belgium
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calcitonin. Incidence of thyroid cancer significantly increased in the past several decades ( Kuo et al. 2016 ). Tumors most frequently arise from follicular epithelial cells to generate papillary, follicular or anaplastic thyroid cancers. Medullary
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Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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/PTC rearrangements, mutations in BRAF , NRAS , etc., and the PI3K/AKT pathway is activated mostly in poorly differentiated (PDTC) and anaplastic thyroid cancer (ATC) as a result of mutations in ALK , RAS , PIK3CA , AKT , etc. ( Murugan & Xing 2011 , Xing 2013
Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil
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Biotechnology Post-graduation Program, Federal University of São Paulo, São Paulo, Brazil
Estructural and Functional Biology Program, Federal University of São Paulo, São Paulo, Brazil
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Biotechnology Post-graduation Program, Federal University of São Paulo, São Paulo, Brazil
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Post-Graduation Program Molecular Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
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Endocrinology Service of Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
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Post-Graduation Program Medicine and Health, Faculty of Medical Sciences, Federal University of Bahia, Salvador, Bahia, Brazil
Post-Graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Bahia, Brazil
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reported ( Hishinuma et al. 2005 ), including in association with an anaplastic thyroid cancer ( Yoon 2020 ). Homozygous deletion in the NIS protein associated with ITD was reported in a DTC patient who harbored a DHG with a late diagnosis, low
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Dogan S Ricarte-Filho JC Krishnamoorthy GP Xu B 2016 Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers . Journal of Clinical Investigation 126 1052 – 1066 . ( https://doi.org/10.1172/JCI85271 ) Liu
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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). Anaplastic thyroid cancers represent extreme forms of dedifferentiated tumours, and these tumours are characteristically very difficult to treat due to the lack of expression of proteins involved in the thyroid machinery. Expression of the sodium iodide
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current available therapies. Treatments for advanced thyroid cancer will require more insight into thyroid carcinogenesis ( Kojic et al . 2011 ). In this study, we show the elevated expression of MIF and CD74 in papillary and anaplastic thyroid cancer
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Department of Medical Oncology, Calvary Mater Newcastle, Waratah, Australia
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Department of Surgery, John Hunter Hospital, Newcastle, Australia
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School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
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School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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represent anaplastic thyroid cancers than DTC ( Meireles et al. 2007 , van Staveren et al. 2007 , Pilli et al. 2009 ). This is particularly true of TSHR expression, which is downregulated early in monolayer culture due to disruption of follicular