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determining relevant early detection biomarkers, it is important to understand the molecular mechanisms implicated in CaP initiation. Therefore, investigations have focused on premalignant lesions as well as early-stage disease. High-grade prostatic
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National Cancer Institute, Women's Malignancies Branch, Department of Gynecologic Oncology, National Institutes of Health, 10 Center Drive, Building 10, 12N226, Bethesda, Maryland 20892-1906, USA
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). Serous cancers The epithelial cells covering the ovaries have historically been considered the site of origin of all ovarian cancers but recent evidence suggests that high-grade serous carcinoma (HGSC) originates from FT epithelium or the tuboperitoneal
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dedifferentiate to high-grade neoplasms requiring cytotoxic chemotherapy ( Paul et al. 2016 ); in contrast, in tumors responding to therapies (either chemotherapy or targeted drugs) the grade/ proliferative activity may decrease ( Yao et al. 2008 b ) or growth
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antibody revealed the differential expression of ERβ in tissue sections from 132 patients with prostate cancer. Moreover, these authors showed partial loss of ERβ in high-grade prostatic intraepithelial neoplasia (HGPIN) (Table 3 ). Once more, the change
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-regulated Prostate Predictive of high grade tumor Mihelich et al . (2015) miR-24 miR-26b miR-30c miR 93 miR-100 miR-103 miR-106a miR-107 miR
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-based prognostic grading scheme, classifying ACCs as either low or high grade ( Weiss et al . 1989 ). This simple two-class scheme was confirmed by studies of the cancer transcriptome using independent patient cohorts ( de Reynies et al . 2009 , Giordano et al
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thought to display the BRCAness phenotype, namely high-grade serous ovarian cancer (HGSOvCa) and triple-negative breast cancers (described earlier). In patients with HGSOvCa both BRCA1/2 gene mutant and non-mutant patients demonstrated a number of
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–10 was higher in the finasteride group than in the placebo group, suggesting that the benefit of reducing the risk of PCa by finasteride must be weighed against the increased risk of development of high-grade PCa ( Thompson et al . 2003 ). Recently
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with alterations in OXPHOS or mitochondrial metabolism genes ( Lahiguera et al. 2020 ). It was further dissected using high-grade serous ovarian cancer cells that the loss of homologous recombination shifted the burden towards PARP-dependent DNA
Department of Pathology, Red Temática de Investigación Cooperativa en Cáncer (RETICC, Department of Pathology, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Avenida Manuel Siurot S/N, 41013 Seville, Spain
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TAZ has been found in high-grade breast carcinomas, and it has been shown to have an influence on patient prognosis ( Bartucci et al . 2014 ). However, the analysis of TAZ protein expression across different breast cancer phenotypes has not, to our
