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Kevin C Knower Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Sarah Q To Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Yuet-Kin Leung Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Shuk-Mei Ho Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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Colin D Clyne Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia

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identified both common and distinct microRNA profiles induced by either estradiol, BPA or DDT in MCF-7 cells, supporting the notion that although EDCs may mimic estrogenic actions, their activity differs from that of the naturally occurring steroid hormone

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Andrea Weckman Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Fabio Rotondo Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Antonio Di Ieva Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Luis V Syro Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Henriett Butz Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Michael D Cusimano Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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Kalman Kovacs Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery

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other than surgery for MTC has yielded another potential treatment target in microRNA-183, which is overexpressed in sporadic MTC ( Abraham et al . 2011 ). Antagonizing miRNA-183 in an MTC cell line revealed a decrease in viable cancer cells in the

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S G Creemers Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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L J Hofland Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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E Korpershoek Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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G J H Franssen Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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F J van Kemenade Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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W W de Herder Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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R A Feelders Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

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better understanding of ACC pathogenesis, but also to identify specific abnormalities that can be informative for the individual patient. miRNAs Several studies have focused on the relevance of microRNAs (miRNAs), short noncoding sequences regulating gene

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Fidéline Bonnet-Serrano Institut Cochin, INSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, France
Hormonal Biology Laboratory, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Jérôme Bertherat Institut Cochin, INSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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tumors ( Barreau et al. 2013 , Assié et al. 2014 ). For a review of methylation dysregulation in ACC, see Jonker et al. (2017) . miRome MicroRNAs (miRNAs) are small noncoding RNAs of approximately 22 nucleotides, regulating gene expression

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Fábio Pereira Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain

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María Jesús Larriba Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain

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Alberto Muñoz Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain

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gene repression ( Murayama et al . 2004 , Kouzmenko et al . 2011 ). In addition, the possibility that 1,25(OH) 2 D 3 represses gene expression via the up-regulation of microRNAs (miRNAs) has recently emerged ( Gocek et al . 2011 , Thorne et al

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Margarida M Moura Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal

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Branca M Cavaco Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal

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Valeriano Leite Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal

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of the histone methyltransferases EZH2 and SMYD3 expression, but no significant correlation was found with RET or RAS mutational status; however, a comparison with type or risk level of RET mutations was not performed. MicroRNA

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Catalina Simion Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA

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Maria Elvira Cedano-Prieto Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA

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Colleen Sweeney Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA

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employed to target the p53 axis and some are already in clinical trials, highlighting the potential of this approach ( Hong et al . 2014 ). Delivery of tumor suppressor microRNAs (as mimetics) or suppression of oncogenic microRNAs (with antagomirs

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Jennifer Munkley Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK

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al . 2000 ). Androgen regulated in prostate cancer cells ( Munkley et al . 2015 c , Munkley et al . 2016 b )  GALNT7 Initiation of O-glycosylation Identified as oncogene in several types of cancer and controlled by micro-RNAs ( Gaziel

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Caroline Wilson Academic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Sheffield, UK

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Hannah Brown Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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Ingunn Holen Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

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cell dormancy through secretion of thrombospondin 1 ( Ghajar et al . 2013 ). Dormancy is also maintained by the secretion of anti-stromal-derived growth factor-1 (SDF-1) micro-RNAs (miRNAs) from either endothelial cells or other stromal cells within

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Yuriko Mori Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Alexandru V Olaru Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Yulan Cheng Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Rachana Agarwal Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Jian Yang Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Delgermaa Luvsanjav Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Wayne Yu Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Florin M Selaru Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Susan Hutfless Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Mark Lazarev Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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John H Kwon Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Steven R Brant Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Michael R Marohn Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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David F Hutcheon Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Mark D Duncan Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Ajay Goel Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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Stephen J Meltzer Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine

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-suppressive microRNAs silenced by DNA hypermethylation in oral cancer . Cancer Research 68 2094 – 2105 doi:10.1158/0008-5472.CAN-07-5194 . Larsson SC Orsini N Wolk A 2005 Diabetes mellitus and risk of colorectal cancer: a meta-analysis . Journal of

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