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Andrea Weckman
Andrea Weckman
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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Fabio Rotondo
Fabio Rotondo
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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Antonio Di Ieva
Antonio Di Ieva
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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Luis V Syro
Luis V Syro
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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Henriett Butz
Henriett Butz
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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Michael D Cusimano
Michael D Cusimano
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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Kalman Kovacs
Kalman Kovacs
Division of Neurosurgery, Division of Pathology, Department of Neurosurgery, Department of Surgery
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other than surgery for MTC has yielded another potential treatment target in microRNA-183, which is overexpressed in sporadic MTC ( Abraham et al . 2011 ). Antagonizing miRNA-183 in an MTC cell line revealed a decrease in viable cancer cells in the
S G Creemers
S G Creemers
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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L J Hofland
L J Hofland
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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E Korpershoek
E Korpershoek
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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G J H Franssen
G J H Franssen
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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F J van Kemenade
F J van Kemenade
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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W W de Herder
W W de Herder
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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R A Feelders
R A Feelders
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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Rotterdam Adrenal Center, Department of Internal Medicine, Department of Pathology, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
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better understanding of ACC pathogenesis, but also to identify specific abnormalities that can be informative for the individual patient. miRNAs Several studies have focused on the relevance of microRNAs (miRNAs), short noncoding sequences regulating gene
Fidéline Bonnet-Serrano
Fidéline Bonnet-Serrano
Institut Cochin, INSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, France
Hormonal Biology Laboratory, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Hormonal Biology Laboratory, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Jérôme Bertherat
Jérôme Bertherat
Institut Cochin, INSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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tumors ( Barreau et al. 2013 , Assié et al. 2014 ). For a review of methylation dysregulation in ACC, see Jonker et al. (2017) . miRome MicroRNAs (miRNAs) are small noncoding RNAs of approximately 22 nucleotides, regulating gene expression
Fábio Pereira
Fábio Pereira
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
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María Jesús Larriba
María Jesús Larriba
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
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Alberto Muñoz
Alberto Muñoz
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
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gene repression ( Murayama et al . 2004 , Kouzmenko et al . 2011 ). In addition, the possibility that 1,25(OH) 2 D 3 represses gene expression via the up-regulation of microRNAs (miRNAs) has recently emerged ( Gocek et al . 2011 , Thorne et al
Margarida M Moura
Margarida M Moura
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
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Branca M Cavaco
Branca M Cavaco
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
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Valeriano Leite
Valeriano Leite
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
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Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Serviço de Endocrinologia, Clínica Universitária de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal
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of the histone methyltransferases EZH2 and SMYD3 expression, but no significant correlation was found with RET or RAS mutational status; however, a comparison with type or risk level of RET mutations was not performed. MicroRNA
Catalina Simion
Catalina Simion
Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA
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Maria Elvira Cedano-Prieto
Maria Elvira Cedano-Prieto
Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA
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Colleen Sweeney
Colleen Sweeney
Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, 4645 2nd Avenue, Sacramento, California 95817, USA
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employed to target the p53 axis and some are already in clinical trials, highlighting the potential of this approach ( Hong et al . 2014 ). Delivery of tumor suppressor microRNAs (as mimetics) or suppression of oncogenic microRNAs (with antagomirs
Jennifer Munkley
Jennifer Munkley
Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK
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al . 2000 ). Androgen regulated in prostate cancer cells ( Munkley et al . 2015 c , Munkley et al . 2016 b ) GALNT7 Initiation of O-glycosylation Identified as oncogene in several types of cancer and controlled by micro-RNAs ( Gaziel
Caroline Wilson
Caroline Wilson
Academic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Sheffield, UK
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Hannah Brown
Hannah Brown
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
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Ingunn Holen
Ingunn Holen
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
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cell dormancy through secretion of thrombospondin 1 ( Ghajar et al . 2013 ). Dormancy is also maintained by the secretion of anti-stromal-derived growth factor-1 (SDF-1) micro-RNAs (miRNAs) from either endothelial cells or other stromal cells within
Yuriko Mori
Yuriko Mori
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Alexandru V Olaru
Alexandru V Olaru
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Yulan Cheng
Yulan Cheng
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Rachana Agarwal
Rachana Agarwal
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Jian Yang
Jian Yang
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Delgermaa Luvsanjav
Delgermaa Luvsanjav
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Wayne Yu
Wayne Yu
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Florin M Selaru
Florin M Selaru
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Susan Hutfless
Susan Hutfless
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Mark Lazarev
Mark Lazarev
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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John H Kwon
John H Kwon
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Steven R Brant
Steven R Brant
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Michael R Marohn
Michael R Marohn
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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David F Hutcheon
David F Hutcheon
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Mark D Duncan
Mark D Duncan
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Ajay Goel
Ajay Goel
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Stephen J Meltzer
Stephen J Meltzer
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Division of Gastroenterology, Section of Gastroenterology, Department of Surgery, Division of Gastroenterology, Department of Medicine
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-suppressive microRNAs silenced by DNA hypermethylation in oral cancer . Cancer Research 68 2094 – 2105 doi:10.1158/0008-5472.CAN-07-5194 . Larsson SC Orsini N Wolk A 2005 Diabetes mellitus and risk of colorectal cancer: a meta-analysis . Journal of
Garcilaso Riesco-Eizaguirre
Garcilaso Riesco-Eizaguirre
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain
Department of Endocrinology and Nutrition, Hospital Universitario de Móstoles, Madrid, Spain
Molecular Endocrinology Group, Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain
Centro de Investigaciones Biomédicas en Red, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
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Department of Endocrinology and Nutrition, Hospital Universitario de Móstoles, Madrid, Spain
Molecular Endocrinology Group, Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain
Centro de Investigaciones Biomédicas en Red, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
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Pilar Santisteban
Pilar Santisteban
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigaciones Biomédicas en Red, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
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Centro de Investigaciones Biomédicas en Red, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
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Antonio De la Vieja
Antonio De la Vieja
Centro de Investigaciones Biomédicas en Red, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
Endocrine Tumors Unit, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Madrid, Spain
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Endocrine Tumors Unit, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Madrid, Spain
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A network-biology perspective of microRNA function and dysfunction in cancer . Nature Reviews: Genetics 17 719 – 732 . ( https://doi.org/10.1038/nrg.2016.134 ) Braverman LE Ingbar SH 1963 Changes in thyroidal function during adaptation
