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Sarah B Bateni Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
University of Alabama at Birmingham, Department of Surgery, Division of Surgical Oncology, Birmingham, Alabama, USA

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Natalie G Coburn Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Calvin Law Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Simron Singh Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Sten Myrehaug Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Angela Assal Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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Julie Hallet Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Susan Leslie Clinic for Neuroendocrine Tumors, Odette Cancer Centre - Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Clinical evaluative sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

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K Byers LA Sorbye H & Yao JC 2018 Comparative study of lung and extrapulmonary poorly differentiated neuroendocrine carcinomas: a SEER database analysis of 162,983 cases . Cancer 124 807 – 815 . ( https://doi.org/10.1002/cncr.31124

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DOI:
https://doi.org/10.1530/ERC-22-0337
Volume/Issue:
Volume 30: Issue 8
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Takaya Kodama Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Kenji Oki Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Yu Otagaki Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Ryuta Baba Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Akira Okada Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Kiyotaka Itcho Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Kazuhiro Kobuke Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Gaku Nagano Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Haruya Ohno Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Nobuyuki Hinata Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Koji Arihiro Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan

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Celso E Gomez-Sanchez Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi Medical Center, Jackson, Mississippi, USA
Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA

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Masayasu Yoneda Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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Noboru Hattori Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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.1016/j.humpath.2016.03.016 ) 27085553 10.1016/j.humpath.2016.03.016 La Rosa S Furlan D Franzi F Battaglia P Frattini M Zanellato E Marando A Sahnane N Turri-Zanoni M Castelnuovo P , 2013 Mixed exocrine-neuroendocrine carcinoma of

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DOI:
https://doi.org/10.1530/ERC-22-0115
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Volume 29: Issue 8
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G Butturini
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R Bettini
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E Missiaglia
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W Mantovani
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I Dalai
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P Capelli
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M Ferdeghini
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P Pederzoli
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A Scarpa
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M Falconi
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gastroenteropancreatic neuroendocrine carcinomas, only nine reports included NF-PEC (Table 3 ). A total of 68 NF-PEC have been treated with octreotide or lanreotide, but follow-up data are available only for 18 patients ( di Bartolomeo et al. 1996 , Angeletti et al

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DOI:
https://doi.org/10.1677/erc.1.01200
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Volume 13: Issue 4
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Kenzo Nakano
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Toshihiko Masui Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Akitada Yogo Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Yuichiro Uchida Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Asahi Sato Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Yosuke Kasai Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Kazuyuki Nagai Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Takayuki Anazawa
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Yoshiya Kawaguchi Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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Shinji Uemoto Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

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-differentiated pancreatic neuroendocrine tumours (PanNETs) and poorly differentiated pancreatic neuroendocrine carcinoma (PanNEC). Although pancreatic adenocarcinoma (PDAC) has a very dismal clinical prognosis, PanNENs have been regarded as relatively indolent. However

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https://doi.org/10.1530/ERC-20-0028
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Volume 27: Issue 7
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Jennifer A Chan
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David P Ryan Department of Medical Oncology, Department of Hematology/Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Andrew X Zhu Department of Medical Oncology, Department of Hematology/Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Thomas A Abrams
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Brian M Wolpin
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Paige Malinowski
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Eileen M Regan
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Charles S Fuchs
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Matthew H Kulke
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histologically documented, locally unresectable or metastatic carcinoid or pancreatic neuroendocrine tumors of low grade or intermediate histological grade. Patients with poorly differentiated or high-grade neuroendocrine carcinomas were not eligible. Treatment

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https://doi.org/10.1530/ERC-11-0382
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Volume 19: Issue 5
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M Cives Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute

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M Ghayouri Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute

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B Morse Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute

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M Brelsford Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute

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M Black Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute

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A Rizzo Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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A Meeker Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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J Strosberg Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute

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males, and more than three quarters (115/143) had grade 1 or 2 pNETs. No large cell or small cell neuroendocrine carcinomas were included in the study. Twenty-seven patients had hormonally functioning tumors, including 11 patients with gastrinoma

Article Type:
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DOI:
https://doi.org/10.1530/ERC-16-0147
Volume/Issue:
Volume 23: Issue 9
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Andreas Machens Department of General, Visceral and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, D-06097 Halle (Saale), Germany

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Florian Hoffmann Department of General, Visceral and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, D-06097 Halle (Saale), Germany

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Carsten Sekulla Department of General, Visceral and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, D-06097 Halle (Saale), Germany

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Henning Dralle Department of General, Visceral and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, D-06097 Halle (Saale), Germany

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patients by quantitative lymph node analysis . Cancer 88 1909 – 1915 . Machens A Haedecke J Holzhausen HJ Thomusch O Schneyer U Dralle H 2000b Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by

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https://doi.org/10.1677/ERC-09-0136
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Volume 16: Issue 4
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Ta-Chun Yuan
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Suresh Veeramani
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Ming-Fong Lin
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, Caprioli RM, Tsukamoto T, Shappell SB & Matusik RJ 2001 A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential. Cancer Research 61 2239 –2249

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https://doi.org/10.1677/ERC-07-0061
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Volume 14: Issue 3
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Elke Tatjana Aristizabal Prada Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Vera Heinzle Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Thomas Knösel Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany

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Svenja Nölting Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Gerald Spöttl Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Julian Maurer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Christine Spitzweg Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Martin Angele Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Nina Schmidt Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Felix Beuschlein Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland

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Günter K Stalla Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany

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Rainer Blaser Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Klaus A Kuhn Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Christoph J Auernhammer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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al . 2017 ). In a large-cell neuroendocrine carcinoma (LCNEC) cell line the pan-Trk inhibitor AZD7451 showed promising pharmacologic potential, particularly in cells with a NTRK gene fusion with constitutive Trk expression ( Tatematsu et al . 2014

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0201
Volume/Issue:
Volume 25: Issue 5
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Thomas J Giordano Divisions of Anatomic Pathology and Molecular & Genomic Pathology, Departments of Pathology and Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA

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, supported by mouse studies, provides evidence that NOTCH functions as a tumor suppressor and master regulator of NE differentiation in SCLC. Skin neuroendocrine tumors Primary cutaneous neuroendocrine carcinoma, termed Merkel cell carcinoma (MCC

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Review Article
DOI:
https://doi.org/10.1530/ERC-18-0116
Volume/Issue:
Volume 25: Issue 8
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