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Wouter T Zandee Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Kimberly Kamp Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Roxanne C van Adrichem Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Richard A Feelders Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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Wouter W de Herder Department of Internal Medicine, Sector Endocrinology, ENETS Centre of Excellence, Erasmus MC, Rotterdam, the Netherlands

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.1159/000087148 ) Jensen RT Cadiot G Brandi ML de Herder WW Kaltsas G Komminoth P Scoazec JY Salazar R Sauvanet A Kianmanesh R 2012 ENETS consensus guidelines for the management of patients with digestive neuroendocrine neoplasms

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0538
Volume/Issue:
Volume 24: Issue 7
Free access
Jan P Dumanski Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Chiara Rasi Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Peyman Björklund Department of Surgical Sciences, Experimental Surgery, Uppsala University, Uppsala, Sweden

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Hanna Davies Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Abir S Ali Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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Malin Grönberg Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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Staffan Welin Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

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Henning Grønbæk Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark

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Janet L Cunningham Department of Neuroscience, Uppsala University, Uppsala, Sweden

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Lars A Forsberg Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Lars Lind Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Erik Ingelsson Division of Cardiovascular Medicine, Department of Medicine, Stanford University, San Francisco, California, USA

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Peter Stålberg Department of Surgical Sciences, Endocrine Surgery, Uppsala University, Uppsala, Sweden

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Per Hellman Department of Surgical Sciences, Endocrine Surgery, Uppsala University, Uppsala, Sweden

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Eva Tiensuu Janson Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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. Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F, Hruban RH, Theise ND et al ., editors. WHO classification of tumors of the digestive system. Lyon: IARC, 2010; b Tumors classified according to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0196
Volume/Issue:
Volume 24: Issue 8
Open access
S M Sadowski Endocrine Surgery, Surgical Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland, USA

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C R C Pieterman Department of Surgical Oncology, Section of Surgical Endocrinology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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N D Perrier Department of Surgical Oncology, Section of Surgical Endocrinology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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F Triponez Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland

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G D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

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. ( https://doi.org/10.1210/jc.2014-3659 ) Grolmusz VK Kovesdi A Borks K Igaz P Patocs A 2018 Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms . European Journal of Endocrinology 179 219 – 228

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0372
Volume/Issue:
Volume 27: Issue 6
Free access
S M Sadowski Thoracic and Endocrine Surgery and Faculty of Medicine University Hospitals of Geneva, Geneva, Switzerland

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G Cadiot Gastroenterology and Hepatology University Hospital of Reims, Reims, France

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E Dansin Oncology Oscar Lambret Cancer Center, University of Lille, Lille, France

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P Goudet Endocrine Surgery University Hospital of Dijon, and INSERM, U866, Epidemiology and Clinical Research in Digestive Oncology Team, and INSERM, CIC1432, Clinical Epidemiology Unit, University Hospital of Dijon, Clinical Investigation Centre, Clinical Epidemiology/Clinical Trials Unit, Dijon, France

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F Triponez Thoracic and Endocrine Surgery and Faculty of Medicine University Hospitals of Geneva, Geneva, Switzerland

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2016 Bronchopulmonary neuroendocrine neoplasms and their precursor lesions in multiple endocrine neoplasia type 1 . Neuroendocrinology 103 240 – 247 . ( doi:10.1159/000435921 ) Baudin E Caron P Lombard-Bohas C Tabarin A Mitry

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0285
Volume/Issue:
Volume 24: Issue 10
Free access
Claire K Mulvey Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Alan Paciorek Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

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Farhana Moon Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Paige Steiding Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Brandon Shih Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Matthew A Gubens Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Li Zhang Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

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Emily K Bergsland Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Iona Cheng Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

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Introduction Neuroendocrine neoplasms (NENs) are a heterogeneous group of cancers that arise from neuroendocrine cells in almost any organ in the body. NENs can produce hormones and are classified histologically as well

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0068
Volume/Issue:
Volume 31: Issue 1
Open access
Z Hamze INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C Vercherat INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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A Bernigaud-Lacheretz INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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W Bazzi INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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R Bonnavion INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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J Lu INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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A Calender INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C Pouponnot INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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P Bertolino INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C Roche INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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R Stein INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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J Y Scoazec INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France
INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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C X Zhang INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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M Cordier-Bussat INSERM U1052/CNRS UMR5286/Université de Lyon, Service de Génétique Moléculaire et Clinique, UMR 3347/CNRS, Service Central d'Anatomie et Cytologie Pathologiques, Department of Molecular Physiology and Biophysics, Lyon1 UMR-S1052, Cancer Research Center of Lyon, Lyon F-69008, France

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were classified as neuroendocrine neoplasms G1 and the other five were neuroendocrine neoplasms G2. One tumour was associated with MEN1 syndrome, while the others were sporadic. Three patients had distant metastases. Murine tissues Pancreatic islets and

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Research Article
DOI:
https://doi.org/10.1530/ERC-13-0164
Volume/Issue:
Volume 20: Issue 6
Free access
Nicole Panarelli Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Kathrin Tyryshkin Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Justin Jong Mun Wong Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Adrianna Majewski Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Xiaojing Yang Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada

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Theresa Scognamiglio Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Michelle Kang Kim Center for Carcinoid and Neuroendocrine Tumors of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Kimberly Bogardus HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Thomas Tuschl HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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Yao-Tseng Chen Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA

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Neil Renwick Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
HHMI, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA

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as a biomarker of patient survival . Modern Pathology [epub]. ( https://doi.org/10.1038/s41379-018-0010-1 ) Bellizzi AM 2013 Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnostic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0244
Volume/Issue:
Volume 26: Issue 1
Free access
Aleksander Skardal Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA
The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA

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Hemamylammal Sivakumar Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA

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Marco A Rodriguez Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA

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Liudmila V Popova Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Priya H Dedhia The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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primary patient tumors. This study demonstrated that combined deletion of TP53 and RB1 conferred features of neuroendocrine neoplasm to normal colon organoids ( Kawasaki et al. 2020 ). Other Matrigel studies focused on a rare NET, duodenal gastrinoma

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Review Article
DOI:
https://doi.org/10.1530/ERC-23-0344
Volume/Issue:
Volume 31: Issue 4
Restricted access
Klaas Van Den Heede Department of Surgery, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences, Lund University, Lund, Sweden
Department of General and Endocrine Surgery, OLV Clinic Aalst, Aalst, Belgium

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Swathikan Chidambaram Department of Surgery and Cancer, Imperial College London, London, UK
Department of Endocrine Surgery, Hammersmith Hospital, London, UK

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Sam Van Slycke Department of General and Endocrine Surgery, OLV Clinic Aalst, Aalst, Belgium
Department of Head and Skin, University Hospital Ghent, Ghent, Belgium
Department of General Surgery, AZ Damiaan, Ostend, Belgium

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Nele Brusselaers Center for Translational Microbiome Research Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Global Health Institute, University of Antwerp, Wilrijk, Belgium

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Carl Fredrik Warfvinge Department of Clinical Sciences, Lund University, Lund, Sweden
Department of Oncology and Pathology, Lund University, Lund, Sweden

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Håkan Ohlsson Department of Clinical Sciences, Lund University, Lund, Sweden
Department of Surgery, Ystad Hospital, Ystad, Sweden

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Rita Gustafsson Department of Gastroenterology and Hepatology, Lund University, Lund, Sweden

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Erik Nordenström Department of Surgery, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences, Lund University, Lund, Sweden

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Martin Almquist Department of Surgery, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences, Lund University, Lund, Sweden

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patients with small bowel neuroendocrine neoplasms in the Netherlands . World Journal of Surgery 45 2482 – 2491 . ( https://doi.org/10.1007/s00268-021-06119-y ) Landerholm K Zar N Andersson RE Falkmer SE Jarhult J 2011 Survival and prognostic

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Research Article
DOI:
https://doi.org/10.1530/ERC-21-0354
Volume/Issue:
Volume 29: Issue 3
Restricted access
Katarina Edfeldt Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Tanveer Ahmad Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Göran Åkerström Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Eva Tiensuu Janson Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Per Hellman Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Peter Stålberg Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Peyman Björklund Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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Gunnar Westin Departments of Surgical Sciences, Medical Sciences, Uppsala University Hospital, Uppsala University, Entrance 70, 3 tr, SE-75185 Uppsala, Sweden

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intestine, especially in the distal ileum. According to the WHO classification system, from year 2010, SI-NETs are divided into three grades ( Bosman et al . 2010 ); Grade 1 Neuroendocrine neoplasm (Ki67 <3%), Grade 2 Neuroendocrine neoplasm (Ki67 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0419
Volume/Issue:
Volume 21: Issue 2
Free access