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Kyoungjune Pak Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Seong-Jang Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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In Joo Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Bo Hyun Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Sang Soo Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Yun Kyung Jeon Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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cells are cytological features of FNs, which include follicular adenomas, follicular carcinomas, nodular goiters, and follicular variants of papillary carcinoma ( Lowhagen & Sprenger 1974 ). Because a follicular carcinoma cannot be distinguished from a

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Bruno Heidi Nozima Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Thais Biude Mendes Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Gustavo José da Silva Pereira Department of Pharmacology, Calcium Signaling and Cell Death Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Rodrigo Pinheiro Araldi Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Edna Sadayo Miazato Iwamura Laboratório de Patologia Molecular, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Soraya Soubhi Smaili Department of Pharmacology, Calcium Signaling and Cell Death Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Gianna Maria Griz Carvalheira Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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Janete Maria Cerutti Division of Genetics, Department of Morphology and Genetics, Genetic Bases of Thyroid Tumors Laboratory, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

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suggested that FAM129A inhibits autophagy in both cancer cell lines. Figure 3 (A) Thyroid papillary carcinoma (TPC1) and (B) follicular thyroid carcinoma (FTC-236) cells expressing mCherry-eGFP-LC3B autophagy marker whereby FAM129A was silenced

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Roberto Bellelli Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Maria Domenica Castellone Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Ginesa Garcia-Rostan Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Clara Ugolini Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Carmelo Nucera Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Peter M Sadow Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Tito Claudio Nappi Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Paolo Salerno Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Maria Carmela Cantisani Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Fulvio Basolo Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Tomas Alvarez Gago Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Giuliana Salvatore Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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Massimo Santoro Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale ‘G. Salvatore’, Institute of Biology and Molecular Genetics, Department of Surgery, Human Thyroid Cancers Preclinical and Translational Research Program, Department of Pathology, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, ‘L. Califano’, Universita' Federico II, Napoli, Italy

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carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas . Journal of Clinical Endocrinology and Metabolism 88 5399 – 5404 . ( doi:10.1210/jc.2003-030838 ). Nucera C Nehs MA Mekel M Zhang X Hodin R Lawler

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Roman Vangoitsenhoven Laboratory of Experimental Medicine and Endocrinology, Departments of Internal Medicine, Endocrinology, Catholic University of Leuven, Leuven, Belgium
Laboratory of Experimental Medicine and Endocrinology, Departments of Internal Medicine, Endocrinology, Catholic University of Leuven, Leuven, Belgium

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Chantal Mathieu Laboratory of Experimental Medicine and Endocrinology, Departments of Internal Medicine, Endocrinology, Catholic University of Leuven, Leuven, Belgium
Laboratory of Experimental Medicine and Endocrinology, Departments of Internal Medicine, Endocrinology, Catholic University of Leuven, Leuven, Belgium

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Bart Van der Schueren Laboratory of Experimental Medicine and Endocrinology, Departments of Internal Medicine, Endocrinology, Catholic University of Leuven, Leuven, Belgium
Laboratory of Experimental Medicine and Endocrinology, Departments of Internal Medicine, Endocrinology, Catholic University of Leuven, Leuven, Belgium

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-cell hyperplasia (9/9 cases), papillary carcinoma (3/15 cases), and medullary carcinoma (11/12). Available data on the presence GLP1 receptor in different species and tissues are given in Table 1 . Table 1 Difference between species in regard to the presence of

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Katrin-Janine Heiliger
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Julia Hess
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Donata Vitagliano Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Paolo Salerno Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Herbert Braselmann
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Giuliana Salvatore Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Clara Ugolini Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Isolde Summerer Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Tatjana Bogdanova Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Kristian Unger Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Gerry Thomas Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Massimo Santoro Research Unit of Radiation Cytogenetics, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Division of Pathology, Institute of Radiation Biology, Institute of Endocrinology and Metabolism, Department of Surgery and Cancer, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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Horst Zitzelsberger
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Santoro M Fusco A 1998 The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids . Cancer Research 58 5523 – 5528 . Powell N Jeremiah S Morishita M Dudley E Bethel J Bogdanova T Tronko M Thomas G

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Kathleen A Luckett Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jennifer R Cracchiolo Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Gnana P Krishnamoorthy Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Luis Javier Leandro-Garcia Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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James Nagarajah Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Mahesh Saqcena Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Rona Lester Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Soo Y Im Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Zhen Zhao Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Scott W Lowe Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Elisa de Stanchina Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Eric J Sherman Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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Alan L Ho Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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Steven D Leach Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jeffrey A Knauf Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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James A Fagin Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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R Salvatore G Fusco A 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas . Journal of Clinical Endocrinology and Metabolism 88

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Eleanor L Woodward Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Andrea Biloglav Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Naveen Ravi Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Minjun Yang Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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Lars Ekblad Division of Oncology and Pathology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

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Johan Wennerberg Division of Otorhinolaryngology/Head and Neck Surgery, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden

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Kajsa Paulsson Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

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ET Gandhi M Biddinger PW Knauf JA Basolo F Zhu Z Giannini R Salvatore G Fusco A 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising

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N Burrows School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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J Resch School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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R L Cowen School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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R von Wasielewski School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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C Hoang-Vu School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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C M West School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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K J Williams School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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G Brabant School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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expression in melanoma . Cancer Research 67 3177 – 3184 . Lee JH Lee ES Kim YS 2007 Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis . Cancer 110 38

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J Lado-Abeal UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain
UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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R Celestino UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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S B Bravo UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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M E R Garcia-Rendueles UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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J de la Calzada UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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I Castro UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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P Castro UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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C Espadinha UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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F Palos UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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P Soares UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain
UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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C V Alvarez UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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M Sobrinho-Simões UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain
UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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J Cameselle-Teijeiro UETeM (Unidade de Enfermedades Tiroideas e Metabolicas), Endocrinology Division, Department of Physiology, IPATIMUP (Institute of Molecular Pathology and Immunology, Endocrinology Section, Molecular Endocrinology Group, Department of Pathology, Department of Pathology, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela 15705, Spain

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. 2007 ). PAX8 – PPAR γ rearrangements have been also detected in 38% of the follicular variant of papillary carcinoma and 33% of follicular adenomas ( Castro et al . 2006 ). Here, we report the case of a patient presenting with hyperthyroidism caused

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Alessandro Antonelli Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Silvia Martina Ferrari Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Poupak Fallahi Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Silvia Frascerra Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Simona Piaggi Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Stefania Gelmini Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Cristiana Lupi Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Michele Minuto Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Piero Berti Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Salvatore Benvenga Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Fulvio Basolo Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Claudio Orlando Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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Paolo Miccoli Department of Internal Medicine, Department of Surgery, Pathology Unit, Clinical Biochemistry Unit, Department of Endocrinology, Department of Experimental Pathology

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derived from papillary carcinomas. According to real time RT-PCR results, the TLR3 expression versus the reference gene (GAPDH) ranges from 0.8 to 1.2, while the expression of WNT5a from 4.15 to 4.90. Discussion The results of the present study demonstrate

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