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involved in the growth of tamoxifen resistant human breast cancer cells . Breast Cancer Research and Treatment 104 165 – 179 . ( doi:10.1007/s10549-006-9399-1 ). Fu X Osborne CK Schiff R 2013 Biology and therapeutic potential of PI3K
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, Thibault A, Liu L, Weber J & Samid D 1995 Therapeutic potentials of 5-aza-2′-deoxycytidine on human prostatic cancer cells. Proceedings of the American Association for Cancer Research 36 404 . Pruzan R
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Geriatrics Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
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express AR-FL and AR-V7. These studies support the idea that targeting domains common to both AR-FL and AR-Vs, such as the DBD, has therapeutic potential. Human studies have not been performed yet. Summary The full-length AR is a classical nuclear
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activity, was shown to induce autophagy and to promote the switch from pro-survival to pro-death autophagy in PTC cells ( Zeybek et al . 2011 ). Further, reversine, a synthetic purine analog with promising therapeutic potential, has recently been shown to
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leptin signaling. Third, we highlighted that the observed chemosensitivity promoting effects depend on NR2F6 abundance in BCa cells, and we validated the therapeutic potential of using the replenishment of NR2F6 against DTX resistance in a patient
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
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) revealed several kinases, for instance MERTK, to be over-activated in CaP compared to benign prostate, suggesting important roles in late-stage CaP and supporting their therapeutic potential. For several of these kinases, inhibitors have been developed
Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Oncology 14 247 – 258 . ( https://doi.org/10.1038/nrclinonc.2016.183 ) 27845767 Galluzzi L Bravo-San Pedro JM Levine B Green DR Kroemer G 2017 b Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles . Nature
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Cancer Center at Illinois, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
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Cancer Center at Illinois, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA
Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
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that inhibition of CYP27A1 and thus M-MDSCs may enhance the therapeutic potential of checkpoint inhibitors. MOE cells were grafted into the bursa/ovary of mice and allowed to establish for 7 days. Based on a pilot study, the mean tumor size at this
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colorectal carcinoma cells containing activated alleles of Ras or Raf, though it was not clear whether this activity is due to cytotoxic versus cytostatic effects ( Yun et al . 2009 ). Although glycolytic inhibitors demonstrate therapeutic potential in
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Division of Medical Pharmacology, Department of Human Genetics, Swammerdam Institute for Life Sciences, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands
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MYCN oncoprotein targets and their therapeutic potential . Cancer Letters 293 144 – 157 . doi:10.1016/j.canlet.2010.01.015 . Bhalla KN 2003 Microtubule-targeted anticancer agents and apoptosis . Oncogene 22 9075 – 9086 . doi:10.1038/sj