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M Christine Bruce Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9

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Danielle McAllister Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9

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Leigh C Murphy Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9

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involved in the growth of tamoxifen resistant human breast cancer cells . Breast Cancer Research and Treatment 104 165 – 179 . ( doi:10.1007/s10549-006-9399-1 ). Fu X Osborne CK Schiff R 2013 Biology and therapeutic potential of PI3K

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Annamaria Biroccio Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy

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Carlo Leonetti Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy

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, Thibault A, Liu L, Weber J & Samid D 1995 Therapeutic potentials of 5-aza-2′-deoxycytidine on human prostatic cancer cells. Proceedings of the American Association for Cancer Research 36 404 . Pruzan R

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Takuma Uo Department of Medicine, University of Washington, Seattle, Washington, USA

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Stephen R Plymate Department of Medicine, University of Washington, Seattle, Washington, USA
Geriatrics Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA

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Cynthia C Sprenger Department of Medicine, University of Washington, Seattle, Washington, USA

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express AR-FL and AR-V7. These studies support the idea that targeting domains common to both AR-FL and AR-Vs, such as the DBD, has therapeutic potential. Human studies have not been performed yet. Summary The full-length AR is a classical nuclear

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Federica Morani Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Rossella Titone Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Loredana Pagano Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Alessandra Galetto Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Oscar Alabiso Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Gianluca Aimaretti Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Ciro Isidoro Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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activity, was shown to induce autophagy and to promote the switch from pro-survival to pro-death autophagy in PTC cells ( Zeybek et al . 2011 ). Further, reversine, a synthetic purine analog with promising therapeutic potential, has recently been shown to

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Juliang Zhang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Huimin Meng Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Mingkun Zhang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Cun Zhang State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Meiling Huang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Changjiao Yan Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Zhe Wang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Lan Hou Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Liu Yang Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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Rui Ling Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China

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leptin signaling. Third, we highlighted that the observed chemosensitivity promoting effects depend on NR2F6 abundance in BCa cells, and we validated the therapeutic potential of using the replenishment of NR2F6 against DTX resistance in a patient

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Varadha Balaji Venkadakrishnan Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA

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Salma Ben-Salem Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Hannelore V Heemers Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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) revealed several kinases, for instance MERTK, to be over-activated in CaP compared to benign prostate, suggesting important roles in late-stage CaP and supporting their therapeutic potential. For several of these kinases, inhibitors have been developed

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Weijun Wei Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Heather Hardin Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

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Quan-Yong Luo Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Oncology 14 247 – 258 . ( https://doi.org/10.1038/nrclinonc.2016.183 ) 27845767 Galluzzi L Bravo-San Pedro JM Levine B Green DR Kroemer G 2017 b Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles . Nature

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Sisi He Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Liqian Ma Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Amy E Baek Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Anna Vardanyan Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Varsha Vembar Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Joy J Chen Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Adam T Nelson Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Joanna E Burdette Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, USA
Cancer Center at Illinois, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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Erik R Nelson Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Cancer Center at Illinois, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA
Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois at Urbana Champaign, Urbana, Illinois, USA

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that inhibition of CYP27A1 and thus M-MDSCs may enhance the therapeutic potential of checkpoint inhibitors. MOE cells were grafted into the bursa/ovary of mice and allowed to establish for 7 days. Based on a pilot study, the mean tumor size at this

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Jennifer F Barger Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, Ohio 45267, USA

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David R Plas Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, Ohio 45267, USA

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colorectal carcinoma cells containing activated alleles of Ras or Raf, though it was not clear whether this activity is due to cytotoxic versus cytostatic effects ( Yun et al . 2009 ). Although glycolytic inhibitors demonstrate therapeutic potential in

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Carla S Verissimo Division of Medical Pharmacology, Department of Human Genetics, Swammerdam Institute for Life Sciences, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands

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Jan J Molenaar Division of Medical Pharmacology, Department of Human Genetics, Swammerdam Institute for Life Sciences, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands

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Carlos P Fitzsimons Division of Medical Pharmacology, Department of Human Genetics, Swammerdam Institute for Life Sciences, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands
Division of Medical Pharmacology, Department of Human Genetics, Swammerdam Institute for Life Sciences, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands

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Erno Vreugdenhil Division of Medical Pharmacology, Department of Human Genetics, Swammerdam Institute for Life Sciences, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands

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MYCN oncoprotein targets and their therapeutic potential . Cancer Letters 293 144 – 157 . doi:10.1016/j.canlet.2010.01.015 . Bhalla KN 2003 Microtubule-targeted anticancer agents and apoptosis . Oncogene 22 9075 – 9086 . doi:10.1038/sj

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