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Elke Tatjana Aristizabal Prada Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany

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Gerald Spöttl Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany

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Julian Maurer Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany

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Michael Lauseker Institute for Medical Information Sciences, Biometry, and Epidemiology, Campus Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany

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Eva Jolanthe Koziolek Department of Nuclear Medicine, University Medical Center Charité, Berlin, Germany
German Cancer Consortium (DKTK), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany

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Jörg Schrader I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

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Ashley Grossman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Royal Free Hospital ENETS Centre of Excellence, London, UK

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Karel Pacak Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Felix Beuschlein Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland

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Christoph Joseph Auernhammer Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany

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Svenja Nölting Medizinische Klinik und Poliklinik IV, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany

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( Fig. 4A ). Associated with the sub G1 increase and G1 phase cell cycle arrest, we found a decreased baseline CDK1(cdc2) expression and reduced baseline expression of the autophagy marker LC3AII demonstrating reduced autophagy in BON1 RR1 and BON1 RR2

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Jian Teng Department of Surgical Sciences, Division of Urology, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, Wisconsin 53706, USA

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Zun-Yi Wang Department of Surgical Sciences, Division of Urology, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, Wisconsin 53706, USA

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David F Jarrard Department of Surgical Sciences, Division of Urology, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, Wisconsin 53706, USA

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Dale E Bjorling Department of Surgical Sciences, Division of Urology, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, Wisconsin 53706, USA
Department of Surgical Sciences, Division of Urology, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, Wisconsin 53706, USA

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containing 2% fetal bovine serum (FBS) and used between passages 4 and 6. Ureteral urothelial cells immortalized with viral constructs containing human papillomavirus E6 or E7 were also maintained in F-12+ medium and cells passaged <35 times were used. HBUC

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W-D Han
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Y-L Zhao
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Y-G Meng
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L Zang
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Z-Q Wu
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Q Li
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Y-L Si
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K Huang
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J-M Ba
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H Morinaga
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M Nomura
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Y-M Mu
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Biology 17 4059 –4069. Prall OW , Sarcevic B, Musgrove EA, Watts CKW & Sutherland RL 1997 Estrogen-induced activation of Cdk4 and Cdk2 during G 1 -S phase progression ia accompanied by increased cyclin D1 expression and

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Balázs Győrffy Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary
Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary

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András Lánczky Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary

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Zoltán Szállási Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary
Research Laboratory of Pediatrics and Nephrology, Laboratory of Functional Genomics, 2nd Department of Pathology, Center for Biological Sequence Analysis, Children's Hospital, Hungarian Academy of Sciences, Budapest, Hungary

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Panici P Mancuso S 1997 Altered expression of cyclin D1 and CDK4 genes in ovarian carcinomas . International Journal of Cancer 74 390 – 395 . doi:10.1002/(SICI)1097-0215(19970822)74:4<390::AID-IJC5>3.0.CO;2-Q . Masciullo V Ferrandina G

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Yuanliang Li Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yiying Guo Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Zixuan Cheng Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Chao Tian Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yingying Chen Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Ruao Chen Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Fuhuan Yu Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China

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Yanfen Shi Department of Pathology, China-Japan Friendship Hospital, Beijing, China

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Fei Su Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

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Shuhua Zhao Department of Biological Information Research, HaploX Biotechnology Co., Ltd, Shenzhen, Guangdong, China

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Zhizheng Wang Academic Department, HaploX Biotechnology, Co., Ltd, Shenzhen, Guangdong, China

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Jie Luo Department of Pathology, China-Japan Friendship Hospital, Beijing, China

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Huangying Tan Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China

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 = 4), followed by MET amplification ( n  = 2, 11.1%). Other potentially targetable CNVs included amplification of CDK4 , EGFR , ERBB2 , and deletion of SMARCB1 (each n  = 1, 5.5%) ( Fig. 6A ). The total targetable gene list and corresponding

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Tiago Bordeira Gaspar i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
ICBAS – Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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José Manuel Lopes i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar e Universitário de São João, Porto, Portugal

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Paula Soares i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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João Vinagre i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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2014, Gillam et al. described two double transgenic models using two other cell cycle regulators, cyclin-dependent kinases (Cdk) 2 and 4: Men1 +/– ;Cdk2 +/– and Men1 +/– ;Cdk4 +/– . While the first GEMM resulted in insulin-expressing tumor

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Philipp Mayer
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Andreas Harjung
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Marco Breinig
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Lars Fischer Institute of Pathology, Department of General Surgery, Medical Clinic - Gastroenterology and Gastrointestinal Oncology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany

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Volker Ehemann
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Mona Malz
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Hans Scherübl Institute of Pathology, Department of General Surgery, Medical Clinic - Gastroenterology and Gastrointestinal Oncology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany

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Sarah Britsch
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Jens Werner Institute of Pathology, Department of General Surgery, Medical Clinic - Gastroenterology and Gastrointestinal Oncology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany

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Michael A Kern
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Hendrik Bläker
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Peter Schirmacher
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Frank Bergmann
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; 1:500; Cell Signaling), Raf1 (1:200; Santa Cruz Biotechnologies), IGF-IRβ (C-20) (1:200; Santa Cruz Biotechnologies), CDK4 (1:500; Invitrogen), and actin (1:10.000; MP Biomedicals, Munich, Germany). All western immunoblot analyses were performed

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Kelly Brewer Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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Jessica Costa-Guda Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA

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Andrew Arnold Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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activation of partner cyclin-dependent kinases CDK4 and CDK6 at the G1-to-S phase transition of the cell cycle ( Sherr et al. 2016 ), and considerable evidence points to important CDK-independent actions of cyclin D1 as well ( Casimiro et al. 2015

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Mathieu Lupien Dartmouth Medical School, Division of Molecular and Cellular Oncology, Department of Medicine, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA

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Myles Brown Dartmouth Medical School, Division of Molecular and Cellular Oncology, Department of Medicine, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
Dartmouth Medical School, Division of Molecular and Cellular Oncology, Department of Medicine, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA

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mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry . Molecular and Cellular Biology 18 4499 – 4508 . Ruthenburg AJ Allis CD Wysocka J 2007 Methylation of lysine 4 on histone H3: intricacy of writing and reading a

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Lena Weindl Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

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Imke Atreya Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

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Peter Dietrich Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
Institute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

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Sabine Neubeck Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

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Markus F Neurath Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
Deutsches Zentrum Immuntherapie DZI, Erlangen, Germany
Comprehensive Cancer Center CCC-EMN, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

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Marianne Pavel Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany
Deutsches Zentrum Immuntherapie DZI, Erlangen, Germany
Comprehensive Cancer Center CCC-EMN, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

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roles in cell cycle control and regulates both S-phase and G2/M progression ( Do et al . 2013 , Matheson et al. 2016 ). Phosphorylation of cyclin-dependent-kinase 2 (CDK2) by WEE1 kinase suppresses DNA replication stress. Inhibition of WEE1 leads to

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