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Alfredo Berruti
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Massimo Terzolo
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Paola Sperone
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Anna Pia
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Silvia Della Casa
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David J Gross
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Carlo Carnaghi
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Paolo Casali
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Francesco Porpiglia
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Franco Mantero
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Giuseppe Reimondo
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Alberto Angeli
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Luigi Dogliotti
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Introduction Adrenocortical carcinoma (ACC) is an extremely rare disease with an annual incidence ranging between 0.5 and 2 cases per million population ( Crucitti et al. 1996 , Icard et al. 2001 ) in western countries. ACC

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01025
Volume/Issue:
Volume 12: Issue 3
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Daniele Generali
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Stephen B Fox
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Alfredo Berruti
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Maria P Brizzi
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Leticia Campo
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Simone Bonardi
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Simon M Wigfield
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Paolo Bruzzi
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Alessandra Bersiga
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Giovanni Allevi
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Manuela Milani
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Sergio Aguggini
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Luigi Dogliotti
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Alberto Bottini
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Adrian L Harris
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representative regions of each paraffin-embedded breast tumor and sections of 5 μm thickness of each tissue array block were transferred to the glass slides. Quality control was assessed on each block by haepatoxylin and eosin (H&E) staining

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DOI:
https://doi.org/10.1677/erc.1.01216
Volume/Issue:
Volume 13: Issue 3
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Xianhui Ruan Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xianle Shi State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Qiman Dong State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Yang Yu Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiukun Hou Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xinhao Song State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Xi Wei Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Lingyi Chen State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Ming Gao Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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, dehydrated through xylenes and alcohols, and embedded in paraffin. Sections were cut at 5 μm and stained with haematoxylin and eosin (HE) for histological examination. Immunohistochemistry was performed according to standard protocols. Signal was visualized

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0558
Volume/Issue:
Volume 26: Issue 1
Open access
Annamaria Colao Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Carolina Di Somma Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Rosario Pivonello Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Antongiulio Faggiano Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Gaetano Lombardi Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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Silvia Savastano Department of Molecular and Clinical Endocrinology and Oncology, ‘Federico II’ University, Via Sergio Pansini 5, 80131 Naples, Italy

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(96.5%) and the main presenting symptoms are visual defects (67.8%) and headache (41.4%), and the most frequent pituitary deficit was hypogonadism (43.3%). Neurosurgery is the treatment of choice of these tumours ( Jaffe 2006 ). However, because of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0181
Volume/Issue:
Volume 15: Issue 4
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Lidong Wang Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Hao Tan Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Yonglian Huang Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Mingyue Guo Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Yanxu Dong Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Chenxi Liu Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Huai Zhao Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Zhen Liu Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

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Introduction Papillary thyroid carcinoma (PTC), as the most frequent histological subtype, accounts for more than 85% of thyroid cancers ( Canberk et al. 2020 ). The incidence of PTC has markedly increased over the past decades ( He et al

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DOI:
https://doi.org/10.1530/ERC-21-0352
Volume/Issue:
Volume 30: Issue 1
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Dorota Dworakowska Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Centre for Endocrinology, London EC1M 6BQ, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Centre for Endocrinology, London EC1M 6BQ, UK

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Ashley B Grossman Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Centre for Endocrinology, London EC1M 6BQ, UK

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DNA ( van Slegtenhorst et al . 1997 ). The TSC2 gene, which is located on chromosome 16p13, encodes a transcript of 5.5 kb, containing 41 exons and encompassing 40 kb genomic DNA ( Xu et al . 1995 ; Fig. 1 ). TSC1 and TSC2 genes encode

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Research Article
DOI:
https://doi.org/10.1677/ERC-08-0142
Volume/Issue:
Volume 16: Issue 1
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Susan Ha Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA
Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA

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Rachel Ruoff Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA
Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA

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Nicole Kahoud Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA
Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA

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Thomas F Franke Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA
Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA

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Susan K Logan Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA
Departments of, Pharmacology, Urology and NYU Cancer Institute, Psychiatry, Department of Nephrology, New York University School of Medicine, 550 First Avenue, MSB424, New York, New York 10016, USA

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prostate of the transgenic animals relative to WT mice. Comparable levels of keratin 14 ( Fig. 4 A) suggest that there was no loss of basal epithelial cells, consistent with the lack of a tumorigenic phenotype in the myr-Akt1 animals. Figure 5 H&E staining

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0204
Volume/Issue:
Volume 18: Issue 2
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Ali S Alzahrani Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Meshael Alswailem Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Alexandre Buffet Université Paris Cité, Inserm, Paris Centre de Recherche Cardiovasculaire (PARCC), Equipe Labellisée Ligue contre le Cancer, Paris, France
Département de Médecine Génomique des Tumeurs et des Cancers, Fédération de Génétique et de Médecine Génomique, Assistance Publique-Hôpitaux de Paris (AP-HP) Centre, Hôpital Européen Georges Pompidou, Paris, France

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Balgees Alghamdi Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Lulu Alobaid Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Osamah Alsagheir Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Hindi Al-Hindi Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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) did not reveal any pathogenic variant. The primers and PCR conditions were described previously ( Albattal et al. 2019 ). Subsequently, an EPAS1 variant (NM_001430.5: c.1592C>A, p.Pro531His) was found by next-generation sequencing (NGS) of tumor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0303
Volume/Issue:
Volume 31: Issue 8
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Eva S Schernhammer
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Shelley S Tworoger
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A Heather Eliassen
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Stacey A Missmer
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Jeff M Holly
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Michael N Pollak
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Susan E Hankinson
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examined the cross-sectional associations of birth weight, body shape at ages 5 and 10, BMI at age 18 and adulthood, bra cup size at age 20, adult waist circumference and waist-to-hip ratio (WHR), as well as attained height in relation to IGF-I, IGFBP-3

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0080
Volume/Issue:
Volume 14: Issue 3
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James C Yao University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Jonathan Strosberg Department of GI Oncology, Moffitt Cancer Center, Tampa, Florida, USA

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Nicola Fazio European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Marianne E Pavel Department of Medicine 1, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

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Emily Bergsland UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA

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Philippe Ruszniewski Hôpital Beaujon, University of Paris, Paris, France

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Daniel M Halperin University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Daneng Li City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA

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Salvatore Tafuto Sarcomas and Rare Tumours Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy

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Nitya Raj Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Davide Campana Department of Clinical Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, ENETS Center of Excellence, Bologna, Italy

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Susumu Hijioka National Cancer Center Japan Tsukiji Campus, Department of Hepatobiliary and Pancreatic Oncology, Tokyo, Japan

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Markus Raderer Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria

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Rosine Guimbaud CHU de Toulouse, Toulouse, France

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Pablo Gajate Hospital Universitário Ramón y Cajal, Clinical Oncology Department, Madrid, Spain

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Sara Pusceddu Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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Albert Reising Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Evgeny Degtyarev Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Mark Shilkrut Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simantini Eddy Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Simron Singh Sunnybrook Health Sciences Centre, Toronto, Canada

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every 30 days up to 150 days following the last dose, or until the start of subsequent antineoplastic medication between 30 and 150 days after the last dose. The European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and EQ-5D-5L

Article Type:
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DOI:
https://doi.org/10.1530/ERC-20-0382
Volume/Issue:
Volume 28: Issue 3
Restricted access