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Athanasios Bikas Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Kirk Jensen Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Aneeta Patel Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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John Costello Jr Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Dennis McDaniel Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Joanna Klubo-Gwiezdzinska Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Olexander Larin Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Victoria Hoperia Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Kenneth D Burman Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Lisa Boyle Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Leonard Wartofsky Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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Vasyl Vasko Division of Endocrinology, Department of Pediatrics, Biomedical Instrumental Center, Center for Endocrine Surgery, Department of Surgery, Department of Medicine, Medstar Washington Hospital Center, 110 Irving Street Northwest, Washington, District of Columbia 20010, USA

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-proliferative effects of metformin on endometrial cancer cells ( Takahashi et al . 2014 ). Metformin is considered as a mitotoxic drug and studies in human cancer cells have demonstrated its inhibitory effect on mitochondrial complex I activity ( Wheaton et al . 2014

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0402
Volume/Issue:
Volume 22: Issue 6
Free access
Damien A Leach Division of Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial, College London, Hammersmith Hospital Campus, London, UK

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Sue M Powell Division of Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial, College London, Hammersmith Hospital Campus, London, UK

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Charlotte L Bevan Division of Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial, College London, Hammersmith Hospital Campus, London, UK

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perspectives on prostate cancer progression . Current Drug Targets 14 441 – 449 . ( doi:10.2174/1389450111314040005 ) Brasky TM Moysich KB Cohn DE White E 2013 Non-steroidal anti-inflammatory drugs and endometrial cancer risk in the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0319
Volume/Issue:
Volume 23: Issue 11
Free access
Diana Lim Department of Pathology, National University Health System, Singapore, Singapore

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Joanne Ngeow Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, Singapore, Singapore

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). Increased PARPi sensitivity was demonstrated in cell line studies and xenograft models with PTEN mutation ( Mendes-Pereira et al . 2009 ). There is also clinical evidence that PARPi may have a therapeutic utility in PTEN -deficient endometrial cancer

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0116
Volume/Issue:
Volume 23: Issue 6
Free access
Brandi B Knight Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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Gabriela M Oprea-Ilies Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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Arumugam Nagalingam Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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Lily Yang Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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Cynthia Cohen Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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Neeraj K Saxena Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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Dipali Sharma Department of Hematology and Medical Oncology, Department of Pathology and Laboratory Medicine, Emory Winship Cancer Institute, Department of Surgery, Department of Medicine, Department of Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA

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, many laboratories including ours have shown that leptin increases proliferation of breast, endometrial, hepatocellular, and many other cancer cells via multiple signaling pathways including Stat3/ERK/Akt signaling ( Housa et al . 2006 , Sharma et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0075
Volume/Issue:
Volume 18: Issue 4
Free access
Shu Zhang Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Ping Lei Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Xinyi Liu Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Xiangrong Li Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Kelcey Walker Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Leela Kotha Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Craig Rowlands Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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Stephen Safe Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA
Institute of Biosciences and Technology, Department of Veterinary Physiology and Pharmacology, Dow Chemical Company, Texas A&M Health Science Center, 2121 Holcombe Boulevard, Houston, Texas 77030, USA

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drug target for a number of diseases including ER-positive breast cancer, endometrial, prostate and pancreatic cancer and also for some autoimmune diseases ( McDougal et al . 1997 , 2001 , Castro-Rivera et al . 1999 , Jana et al . 2000 , Wormke

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0054
Volume/Issue:
Volume 16: Issue 3
Free access
Theodora S Ross Department of Internal Medicine and High-Risk Cancer Program, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390-8852, USA

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‘endometrial or ovarian’ cancer in her 60s and one of his three brothers died of ‘adrenal’ cancer at age 50. Grace's mother was a healthy member of a large Polish Catholic family in which only she and a sister were diagnosed with breast cancers in their late 60

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0186
Volume/Issue:
Volume 19: Issue 4
Free access
V Craig Jordan Dallas/Ft. Worth Living Legend Chair of Cancer Research, Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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cancer and longer adjuvant therapy (5 years) was better than shorter (1–2 years) therapy. Concern about an increased incidence of fatal endometrial cancer was calculated to be manageable. A gynaecological examination before adjuvant tamoxifen therapy

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0335
Volume/Issue:
Volume 28: Issue 1
Free access
V Craig Jordan Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA

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tamoxifen trials was consistently at 50% and safety with endometrial cancer in postmenopausal women was much less significant than feared. Also, the concern about tamoxifen-induced rat hepatocarcinogenesis was not translated to human treatment trials. The

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0092
Volume/Issue:
Volume 21: Issue 3
Free access
Lamis Yehia Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Germline High Risk Cancer Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA

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prostate, kidney, endometrial, breast and brain cancers ( Li & Sun 1997 , Li et al . 1997 , Risinger et al . 1997 , Steck et al . 1997 ) and considered as one of the most frequently somatically mutated genes in human cancers ( Cantley & Neel 1999

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0162
Volume/Issue:
Volume 25: Issue 8
Free access
Xuan Chen Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Sixuan Liu Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xue Peng Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xiangyun Zong Department of Breast Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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as cervical cancer, endometrial cancer, ovarian epithelial cancer, and breast cancer ( Peluso et al. 2014 , Vaz-Luis & Partridge 2018 ). Therefore, AMH can unexpectedly contribute to the reduction of the growth and metastasis of breast cancer cells

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0060
Volume/Issue:
Volume 30: Issue 10
Open access