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Kimberly Kamp, Ronald A M Damhuis, Richard A Feelders, and Wouter W de Herder

– 194 . Yao JC Eisner MP Leary C Dagohoy C Phan A Rashid A Hassan M Evans DB 2007 Population-based study of islet cell carcinoma . Annals of Surgical Oncology 14 3492 – 3500 . doi:10.1245/s10434-007-9566-6 . Yao JC Hassan M

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Vincenzo Marotta, Maria Chiara Zatelli, Concetta Sciammarella, Maria Rosaria Ambrosio, Marta Bondanelli, Annamaria Colao, and Antongiulio Faggiano

Baron RL Haradome H Kawamori Y Nawano S Araki T 2000 Islet cell tumor of the pancreas: biphasic CT versus MR imaging in tumor detection . Radiology 216 163 – 171 . (

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S M Sadowski, G Cadiot, E Dansin, P Goudet, and F Triponez

– 234 . ( doi:10.1016/j.dld.2011.09.014 ) Bartsch DK Schilling T Ramaswamy A Gerdes B Celik I Wagner HJ Simon B Rothmund M 2000 Management of nonfunctioning islet cell carcinomas . World Journal of Surgery 24

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Alaa Sada, Travis J McKenzie, Adrian Vella, Michael J Levy, and Thorvardur R Halfdanarson

D Skarulis MC Jensen RT Gorden P Doppman JL Shawker TH , 1998 Operative management of islet-cell tumors arising in the head of the pancreas . Surgery 124 1056 – 61 . ( ) Park DH Choi J-H Oh D

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A Coopes, C E Henry, E Llamosas, and C E Ford

gynaecological neoplasms ( Jönsson et al . 2002 , Dejmek et al . 2005 , Klemm et al . 2011 , Ford et al . 2014 , Lin et al . 2014 ). siRNA knockdown of Wnt5a in ovarian cancer cell lines reduced proliferation, migration and invasion and promoted cell

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Mohid S Khan and Martyn E Caplin

outpatient administration. It is difficult to assess whether subgroups of pancreatic NETs respond differentially due to small numbers, inconsistent assessment criteria and variable regimens amongst studies. Response rates treating pancreatic islet cell

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Nicole Panarelli, Kathrin Tyryshkin, Justin Jong Mun Wong, Adrianna Majewski, Xiaojing Yang, Theresa Scognamiglio, Michelle Kang Kim, Kimberly Bogardus, Thomas Tuschl, Yao-Tseng Chen, and Neil Renwick

Introduction Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are increasingly common and clinically diverse neoplasms ( Yao et al . 2008 , Lawrence et al . 2011 ) that are challenging to evaluate histologically ( Klimstra 2016

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Roberto Valente, Alastair J Hayes, Sven-Petter Haugvik, Per Hedenström, Darko Siuka, Emilie Korsæth, Daniel Kämmerer, Stuart M Robinson, Patrick Maisonneuve, Gianfranco Delle Fave, Bjorn Lindkvist, and Gabriele Capurso

Introduction Pancreatic neuroendocrine neoplasms (PNENs) are a group of tumors which originate from endocrine cells within the pancreas gland. PNENs have heterogeneous clinical behavior owing to their hormone functional status, cellular

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Edward B Alabraba, Philippe Taniere, Gary M Reynolds, Paul M Stewart, Stephen J Wigmore, and Simon R Bramhall

expressed by cells for them to be responsive. Progesterone receptor (PR) immunoreactivity has been demonstrated in normal pancreas ( Targarona et al . 1991 ) and specifically co-localised to normal insulin-producing β cells in the islets of Langerhans

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M Fraenkel, M Kim, A Faggiano, W W de Herder, G D Valk, and On behalf of the Knowledge NETwork

Introduction Neuroendocrine tumours (NETs) are heterogeneous neoplasms arising from different cells distributed in many organs and tissues that share a common neuroendocrine phenotype. NETs have been recognized as biologically different from