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Luohai Chen Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Institute for Liver and Digestive Disease, Royal Free Hospital, University College London, London, UK

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Gopinath Gnanasegaran Department of Nuclear Medicine, Royal Free London NHS Foundation, London, UK

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Dalvinder Mandair Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Christos Toumpanakis Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Martyn Caplin Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Shaunak Navalkissoor Department of Nuclear Medicine, Royal Free London NHS Foundation, London, UK

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, increasing administered activity or considering alternative treatment. Several studies have assessed the potential role of prognostic markers, such as positivity or metabolic tumour volume on 18 F-fluorodeoxyglucose positron emission tomography ( 18 F

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0248
Volume/Issue:
Volume 29: Issue 2
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W R Miller
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T J Anderson
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S White
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D Evans
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A Krause
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J M Dixon
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for diagnosis may be analysed for predictive markers of response/resistance and related to volume changes of the same tumour during treatment and (iii) sequential samples can be taken from the tumour before, during and after treatment to monitor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00995
Volume/Issue:
Volume 12: Issue Supplement_1
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William R Doerfler Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Elena M Morariu Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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N Paul Ohori Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Simion I Chiosea Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Michael S Landau Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Linwah Yip Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Pooja Manroa Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA
Division of Endocrinology, University of Texas Medical Branch, Galveston, Texas, USA

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testing is being increasingly used in thyroid nodules with indeterminate cytology, including Hürthle cell nodules, to assist in the management of these patients ( Patel et al. 2018 , Steward et al. 2019 ). However, how the molecular markers of Hürthle

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-20-0435
Volume/Issue:
Volume 28: Issue 5
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S Tozlu
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I Girault
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S Vacher
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J Vendrell
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C Andrieu
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F Spyratos
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P Cohen
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R Lidereau
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I Bieche
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each subgroup of samples were characterized by their median values and ranges, rather than their mean values and coefficients of variation, and (b) relationships between the molecular markers and clinical and biological parameters were tested using the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01120
Volume/Issue:
Volume 13: Issue 4
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Wei Wei Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA

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Michael T Lewis Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA
Baylor College of Medicine, Departments of Molecular and Cellular Biology, Radiology, Lester and Sue Smith Breast Center, Houston, Texas, USA

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Charafe-Jauffret et al . (2009) a Percentage estimated from bar graph. Researchers have tried to consolidate the discrepancy by applying different TIC markers to different molecular subtypes of breast cancers ( Ricardo et al . 2011 ) as well as by

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0447
Volume/Issue:
Volume 22: Issue 3
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Kristian Unger
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Johannes Wienberg Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Andrew Riches Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Ludwig Hieber
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Axel Walch Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Andreas Brown
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Patricia C M O'Brien Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Cäcilia Briscoe Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Lindsey Gray Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Elke Rodriguez
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Gerhard Jackl Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Jeroen Knijnenburg Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Giovanni Tallini Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Malcolm Ferguson-Smith Helmholtz Zentrum München, Department Biologie II, Bute Medical School, Institut für Pathologie, Cambridge University Centre for Veterinary Science, Strahlenbiologisches Institut, Department of Molecular Cell Biology, Anatomia Patologica, German Research Center for Environmental Health (GmbH), Department of Radiation Cytogenetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

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Horst Zitzelsberger
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, and usage as a therapeutic target or diagnostic/prognostic marker should be taken into consideration. Our study demonstrated that the molecular analysis of chromosomal breakpoints in radiation-transformed epithelial breast cell lines is able to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0065
Volume/Issue:
Volume 17: Issue 1
Free access
Vivian Rosery Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Henning Reis Institute of Pathology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Konstantinos Savvatakis Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Bernd Kowall Center of Clinical Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University Duisburg-Essen, Essen, Germany

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Martin Stuschke Department of Radiotherapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Andreas Paul German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Alexander Dechêne Department of Gastroenterology and Hepatology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Department of Internal Medicine 6, Paracelsus Medical University, Nürnberg, Germany

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JiaJin Yang Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Ben Zhao Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Arianna Borgers Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Stefan Kasper Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Martin Schuler Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Phyllis F Cheung Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Jens T Siveke Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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prognostic value in highly proliferative GEP-NEN focusing on the inhibitory checkpoint molecules PD-1 and PD-L1, cytotoxic marker CD8, and tumor-associated macrophage (TAM) marker CD206. Spatial imaging was applied to illustrate the spatial distribution and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0223
Volume/Issue:
Volume 28: Issue 10
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Viktor Johanson
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Håkan Ahlman
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Peter Bernhardt
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Svante Jansson
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Lars Kölby
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Fredrik Persson
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Göran Stenman
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Christina Swärd
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Bo Wängberg
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Mats Stridsberg
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Ola Nilsson
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, the animals were carefully examined, and plasma and tumor tissues were collected for analysis of biochemical markers and morphological findings. Statistical analysis The correlations between GOT2 tumor weight and

Article Type:
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DOI:
https://doi.org/10.1677/ERC-06-0033
Volume/Issue:
Volume 14: Issue 2
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Jaume Capdevila
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Lara Iglesias Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Irene Halperin Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Ángel Segura Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Javier Martínez-Trufero Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Maria Ángeles Vaz Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Jesús Corral Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Gabriel Obiols Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Enrique Grande Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Juan Jose Grau Medical Oncology Department, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Medical Oncology Department, Hospital Universitario Ramón y Cajal, Medical Oncology Department, Endocrinology Department, Medical Oncology Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain

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Josep Tabernero
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Introduction Several translational and clinical studies have been designed based on the knowledge of the main molecular steps that lead to the transformation of the normal follicular cell into an invasive thyroid carcinoma, whose results are leading

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0351
Volume/Issue:
Volume 19: Issue 2
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G Bidaux
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M Roudbaraki
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C Merle
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A Crépin
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P Delcourt
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C Slomianny
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S Thebault
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J-L Bonnal
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M Benahmed
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F Cabon
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B Mauroy
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N Prevarskaya
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prostate cancer. It is therefore essential to understand what drives the progression to androgen-independence and identify the molecular markers for both the early androgen-dependent and the advanced androgen-independent prostate cancer stages. It

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00969
Volume/Issue:
Volume 12: Issue 2
Free access