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C J Fabian
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B F Kimler
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M S Mayo
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S A Khan
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, Tworoger et al. 2005 ), serum insulin-like growth factor-I (IGF-I) and its binding protein-3 (IGFBP-3) in premenopausal women ( Hankinson et al. 1998 ), mammographic breast density ( Boyd et al. 1998 ) and breast intra-epithelial neoplasia ( Page

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Hugo Prazeres Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Joana P Couto Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Fernando Rodrigues Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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João Vinagre Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Joana Torres Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Vitor Trovisco Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Teresa C Martins Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Manuel Sobrinho-Simões Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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Paula Soares Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal

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multiple endocrine neoplasia type 2 cancer syndromes (MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC; Eng et al . 1996 , Kouvaraki et al . 2005 , Raue & Frank-Raue 2007 )). RET encodes a membrane receptor tyrosine kinase composed of

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H-C Jennifer Shen
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Jennifer E Rosen
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Lauren M Yang
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Sharon A Savage Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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A Lee Burns Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Carmen M Mateo Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Sunita K Agarwal Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Settara C Chandrasekharappa Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Allen M Spiegel Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Francis S Collins Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Stephen J Marx Tumor Angiogenesis Section, Metabolic Diseases Branch, Genome Technology Branch, Division of Cancer Epidemiology and Genetics, Surgery Branch, National Cancer Institute, Building 10, Room 4W-5940, 10 Center Drive, Bethesda, Maryland 20892, USA

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Steven K Libutti
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome caused by mutations in the MEN1 tumor suppressor gene ( Chandrasekharappa et al . 1997 , Guru et al . 1998 ). MEN1 patients are predisposed to develop

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Andreas Machens Medical Faculty, Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Kerstin Lorenz Medical Faculty, Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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Frank Weber Department of General, Visceral and Transplantation Surgery, Division of Endocrine Surgery, University of Duisburg-Essen, Essen, Germany

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Tim Brandenburg Department of Endocrinology, Diabetology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Dagmar Führer-Sakel Department of Endocrinology, Diabetology and Metabolism, University of Duisburg-Essen, Essen, Germany

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Henning Dralle Medical Faculty, Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
Department of General, Visceral and Transplantation Surgery, Division of Endocrine Surgery, University of Duisburg-Essen, Essen, Germany

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transfection) germline mutations, giving rise to medullary thyroid cancer (MTC), pheochromocytoma, and/or primary hyperparathyroidism in an age-dependent fashion and jointly referred to as multiple endocrine neoplasia type 2 (MEN 2), has become evident over the

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Tobias Else Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, 2560E MSRB2, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109‐5674, USA

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causes for three classic cancer syndromes for which PC is a well-recognized clinical feature were identified: neurofibromatosis type 1 ( NF1 ), von Hippel-Lindau ( VHL ) disease, and multiple endocrine neoplasia type 2 ( RET ) ( Cawthon et al . 1990

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Ernst von Dobschuetz Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Helena Leijon Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Camilla Schalin-Jäntti Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Francesca Schiavi Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Michael Brauckhoff Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Mariola Peczkowska Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Giovanna Spiazzi Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Serena Demattè Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Maria Enrica Cecchini Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Paola Sartorato Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Jolanta Krajewska Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Kornelia Hasse-Lazar Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Katarzyna Roszkowska-Purska Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Elisa Taschin Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Angelica Malinoc Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Lars A Akslen Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Johanna Arola Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Dariusz Lange Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Ambrogio Fassina Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Gianmaria Pennelli Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Mattia Barbareschi Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Jutta Luettges Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Aleksander Prejbisz Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Andrzej Januszewicz Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Tim Strate Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Birke Bausch Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Frederic Castinetti Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Barbara Jarzab Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Giuseppe Opocher Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hartmut P H Neumann Section of Endocrine Surgery Department of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, Germany

Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy

Department of Endocrine Surgery University of Bergen, Bergen, Norway

Department of Hypertension Institute of Cardiology, Warsaw, Poland

Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy

Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy

Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland

Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany

Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway

Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy

Department of Pathology Santa Chiara Regional Hospital, Trento, Italy

Department of Pathology Marienkrankenhaus, Hamburg, Germany

Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany

Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France

Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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), multiple endocrine neoplasia type 2 ( RET gene), and neurofibromatosis type 1 ( NF1 gene) ( Boedeker et al . 2009 , Neumann et al . 2009 , Burnichon et al . 2010 , Castro-Vega et al . 2014 , Yang et al . 2015 ). In patients carrying germline

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Daniela Cordella
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Marina Muzza
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Paolo Beck-Peccoz
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Luca Persani
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activating mutations have been identified as the underlying cause of multiple endocrine neoplasia type-2 (MEN2) and familial medullary thyroid carcinoma (FMTC), whereas somatic RET mutations are detectable in about 50% of sporadic MTCs ( Eng & Mulligan 1997

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Adel Mandl Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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James M Welch Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Gayathri Kapoor Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Vaishali I Parekh Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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David S Schrump Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

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R Taylor Ripley Division of General Thoracic Surgery, Baylor College of Medicine, Houston, Texas, USA

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Mary F Walter NIDDK Clinical Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Jaydira Del Rivero Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

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Smita Jha Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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William F Simonds Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Robert T Jensen Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Lee S Weinstein Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Jenny E Blau Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Sunita K Agarwal Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome (OMIM ID: 131100) carry germline heterozygous loss-of-function mutations in the MEN1 gene which predisposes them to the development of various endocrine and non

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Pierlorenzo Pallante Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Rosa Visone Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Carlo Maria Croce Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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translation or the induction of its degradation ( Ambros 2004 ). The analysis of human neoplasias of different tissue origins has shown deregulated miR expression ( Calin & Croce 2006 , Volinia et al . 2006 ). miR expression profile in PTCs Most

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Asterios Karagiannis
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Dimitri P Mikhailidis Division of Endocrinology, Department of Clinical Biochemistry,, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece

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Vasilios G Athyros
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Faidon Harsoulis
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), multiple endocrine neoplasia type 1 (MEN1) and 2 (MEN2), and the PHEO/PGL syndromes based on the described mutations of the genes for succinate dehydrogenase subunit D (SDHD), B (SDHB), and C (SDHC) ( Baysal et al . 2000 , Neumann et al . 2002 , Amar

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