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, Tworoger et al. 2005 ), serum insulin-like growth factor-I (IGF-I) and its binding protein-3 (IGFBP-3) in premenopausal women ( Hankinson et al. 1998 ), mammographic breast density ( Boyd et al. 1998 ) and breast intra-epithelial neoplasia ( Page
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) – Cancer Biology, Molecular Pathology Service, Endocrinology Service of the Portuguese Institute of Oncology of Coimbra FG, Department of Pathology, Rua Dr Roberto Frias, s/n, 4200-465 Porto, Portugal
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multiple endocrine neoplasia type 2 cancer syndromes (MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC; Eng et al . 1996 , Kouvaraki et al . 2005 , Raue & Frank-Raue 2007 )). RET encodes a membrane receptor tyrosine kinase composed of
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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome caused by mutations in the MEN1 tumor suppressor gene ( Chandrasekharappa et al . 1997 , Guru et al . 1998 ). MEN1 patients are predisposed to develop
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Department of General, Visceral and Transplantation Surgery, Division of Endocrine Surgery, University of Duisburg-Essen, Essen, Germany
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transfection) germline mutations, giving rise to medullary thyroid cancer (MTC), pheochromocytoma, and/or primary hyperparathyroidism in an age-dependent fashion and jointly referred to as multiple endocrine neoplasia type 2 (MEN 2), has become evident over the
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causes for three classic cancer syndromes for which PC is a well-recognized clinical feature were identified: neurofibromatosis type 1 ( NF1 ), von Hippel-Lindau ( VHL ) disease, and multiple endocrine neoplasia type 2 ( RET ) ( Cawthon et al . 1990
Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
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Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
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Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
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Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
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Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
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Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
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Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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Department of Pathology Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Division of Endocrinology Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Familial Cancer Clinic and Onco‐Endocrinology Veneto Institute of Oncology, IRCCS, Padova, Italy
Department of Endocrine Surgery University of Bergen, Bergen, Norway
Department of Hypertension Institute of Cardiology, Warsaw, Poland
Endocrinology Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Units of Internal Medicine Santa Chiara General Hospital, Trento, Italy
Department of Internal Medicine General Hospital, Montebelluna, Treviso, Italy
Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Pathology and Laboratory Diagnostics Skłodowska‐Curie Memorial Institute of Oncology, Warsaw, Poland
Section for Preventive Medicine Department of Nephrology and General Medicine, Albert‐Ludwigs‐University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
Section for Pathology Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Tumor Pathology M.Sklodowska‐Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Surgical Pathology and Cytopathology Unit Department of Medicine, DIMED, University of Padova, Padova, Italy
Department of Pathology Santa Chiara Regional Hospital, Trento, Italy
Department of Pathology Marienkrankenhaus, Hamburg, Germany
Department of Gastroenterology Albert‐Ludwigs‐University of Freiburg, Freiburg, Germany
Department of Endocrinology La Timone Hospital, Hopitaux de Marseille and Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Aix‐Marseille University, Marseille, France
Genomic Medicine Institute Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
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), multiple endocrine neoplasia type 2 ( RET gene), and neurofibromatosis type 1 ( NF1 gene) ( Boedeker et al . 2009 , Neumann et al . 2009 , Burnichon et al . 2010 , Castro-Vega et al . 2014 , Yang et al . 2015 ). In patients carrying germline
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activating mutations have been identified as the underlying cause of multiple endocrine neoplasia type-2 (MEN2) and familial medullary thyroid carcinoma (FMTC), whereas somatic RET mutations are detectable in about 50% of sporadic MTCs ( Eng & Mulligan 1997
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Patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome (OMIM ID: 131100) carry germline heterozygous loss-of-function mutations in the MEN1 gene which predisposes them to the development of various endocrine and non
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
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Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
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translation or the induction of its degradation ( Ambros 2004 ). The analysis of human neoplasias of different tissue origins has shown deregulated miR expression ( Calin & Croce 2006 , Volinia et al . 2006 ). miR expression profile in PTCs Most
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), multiple endocrine neoplasia type 1 (MEN1) and 2 (MEN2), and the PHEO/PGL syndromes based on the described mutations of the genes for succinate dehydrogenase subunit D (SDHD), B (SDHB), and C (SDHC) ( Baysal et al . 2000 , Neumann et al . 2002 , Amar