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Benjamin C Thomas
Benjamin C Thomas
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Jonathan D Kay
Jonathan D Kay
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK
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Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK
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Suraj Menon
Suraj Menon
Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK
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Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK
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Sarah L Vowler
Sarah L Vowler
Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK
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Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK
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Sarah N Dawson
Sarah N Dawson
Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Laura J Bucklow
Laura J Bucklow
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Hayley J Luxton
Hayley J Luxton
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK
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Molecular Diagnostics and Therapeutics Group, University College London, London, UK
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Thomas Johnston
Thomas Johnston
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Charlie E Massie
Charlie E Massie
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular and Computational Diagnostics Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Molecular and Computational Diagnostics Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Michelle Pugh
Michelle Pugh
Genomics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Anne Y Warren
Anne Y Warren
Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Peter Barker
Peter Barker
National Institute for Health Research Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Keith Burling
Keith Burling
National Institute for Health Research Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Andy G Lynch
Andy G Lynch
Computational Biology Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Anne George
Anne George
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Johanna Burge
Johanna Burge
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Marie Corcoran
Marie Corcoran
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Sara Stearn
Sara Stearn
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Alastair D Lamb
Alastair D Lamb
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Naomi L Sharma
Naomi L Sharma
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
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Greg L Shaw
Greg L Shaw
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
University College Hospital at Westmoreland Street, London, UK
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University College Hospital at Westmoreland Street, London, UK
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David E Neal
David E Neal
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, UK
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Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, UK
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Hayley C Whitaker
Hayley C Whitaker
Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK
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Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK
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Introduction Prostate cancer is the leading cause of cancer death in men ( Office for National Statistics 2013 ). Prostate cancer growth relies upon androgens, such as testosterone, binding to the androgen receptor (AR) and promoting AR
Karin Jennbacken
Karin Jennbacken
Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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Tajana Tešan
Tajana Tešan
Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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Wanzhong Wang
Wanzhong Wang
Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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Heléne Gustavsson
Heléne Gustavsson
Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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Jan-Erik Damber
Jan-Erik Damber
Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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Karin Welén
Karin Welén
Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden
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importance for metastasis of prostate cancer ( Xie et al . 2010 ). In contrast to N-cadherin, E-cadherin mediates homotypic interactions between cells, which maintain the integrity of epithelial tissues ( Giehl & Menke 2008 ). Functional studies show that N
S Darby
S Darby
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J Stockley
J Stockley
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M M Khan
M M Khan
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C N Robson
C N Robson
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H Y Leung
H Y Leung
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V J Gnanapragasam
V J Gnanapragasam
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Introduction Prostate cancer remains the most commonly diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA ( Jemal et al. 2006 ). Gonadotrophin-releasing hormone I (GnRH I) analogue
Vijay K Gonugunta
Vijay K Gonugunta
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Lu Miao
Lu Miao
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Gangadhara R Sareddy
Gangadhara R Sareddy
Department of Urology UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USA
Department of Obstetrics and Gynecology UT Health Science Center, San Antonio, Texas, USA
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Department of Obstetrics and Gynecology UT Health Science Center, San Antonio, Texas, USA
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Preethi Ravindranathan
Preethi Ravindranathan
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Ratna Vadlamudi
Ratna Vadlamudi
Department of Urology UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USA
Department of Obstetrics and Gynecology UT Health Science Center, San Antonio, Texas, USA
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Department of Obstetrics and Gynecology UT Health Science Center, San Antonio, Texas, USA
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Ganesh V Raj
Ganesh V Raj
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2007 , Girard et al . 2013 ). This review focuses on the structure, function, and genomic and extranuclear signaling of PELP1, associated signaling pathways, and its role as a target for therapeutic modulation in breast and prostate cancers. PELP1
Parvin Yenki
Parvin Yenki
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Satyam Bhasin
Satyam Bhasin
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Liang Liu
Liang Liu
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Noushin Nabavi
Noushin Nabavi
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Chi Wing Cheng
Chi Wing Cheng
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Kevin J Tam
Kevin J Tam
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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James W Peacock
James W Peacock
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Hans H Adomat
Hans H Adomat
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Tabitha Tombe
Tabitha Tombe
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Ladan Fazli
Ladan Fazli
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Larissa Ivanova
Larissa Ivanova
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Christopher Dusek
Christopher Dusek
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Shahram Khosravi
Shahram Khosravi
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Emma S Tomlinson Guns
Emma S Tomlinson Guns
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Yuzhuo Wang
Yuzhuo Wang
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Ralph Buttyan
Ralph Buttyan
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Martin E Gleave
Martin E Gleave
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Christopher J Ong
Christopher J Ong
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Introduction Despite its initial efficacy, androgen deprivation therapy (ADT) remains a palliative treatment for metastatic prostate cancer, and patients eventually progress to castration-resistant prostate cancer (CRPC) ( So et al. 2005
Penelope D Ottewell
Penelope D Ottewell
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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Ning Wang
Ning Wang
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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Joshua Meek
Joshua Meek
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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C Anne Fowles
C Anne Fowles
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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Peter I Croucher
Peter I Croucher
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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Colby L Eaton
Colby L Eaton
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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Ingunn Holen
Ingunn Holen
Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division
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Introduction Prostate cancer is the most common malignancy and the second most common cause of cancer death in men. In the USA, there were ∼238 590 new prostate cancer diagnoses and more than 29 720 deaths in 2013 ( American Society for Cancer 2013
Wafa Bouleftour
Wafa Bouleftour
Department of Medical Oncology, Lucien Neuwirth cancer institute, Saint Priest en Jarez, Rhône-Alpes, France
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Karima Boussoualim
Karima Boussoualim
Department of rheumatology, North Hospital, university Hospital of Saint-Étienne, Saint-Priest-en-Jarez, Rhône-Alpes, France
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Sandrine Sotton
Sandrine Sotton
Department of Radiotherapy, Lucien Neuwirth Cancerology Institute, Saint Priest en Jarez, Rhône-Alpes, France
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Cecile Vassal
Cecile Vassal
Department of Medical Oncology, Lucien Neuwirth cancer institute, Saint Priest en Jarez, Rhône-Alpes, France
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Thierry Thomas
Thierry Thomas
Department of rheumatology, North Hospital, university Hospital of Saint-Étienne, Saint-Priest-en-Jarez, Rhône-Alpes, France
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Nicolas Magne
Nicolas Magne
Department of Radiotherapy, Lucien Neuwirth Cancerology Institute, Saint Priest en Jarez, Rhône-Alpes, France
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Aline Guillot
Aline Guillot
Department of Medical Oncology, Lucien Neuwirth cancer institute, Saint Priest en Jarez, Rhône-Alpes, France
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decline plays a key role in the rapid loss of bone mass. Prostate cancer (Pca) is the most common cancer among people aged 60 and 70. Between the age of 75 and 79, men are six times more likely to have a high-risk Pca than men aged 55–59 ( Huynh-Le et
Paramita M Ghosh
Paramita M Ghosh
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Shazli N Malik
Shazli N Malik
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Roble G Bedolla
Roble G Bedolla
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Yu Wang
Yu Wang
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Margarita Mikhailova
Margarita Mikhailova
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Thomas J Prihoda
Thomas J Prihoda
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Dean A Troyer
Dean A Troyer
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Jeffrey I Kreisberg
Jeffrey I Kreisberg
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Introduction Prostate cancer is the most commonly diagnosed cancer among men in the Western hemisphere, and is second only to lung cancer as a leading cause of male cancer deaths ( American Cancer Society, 2004 ). Prostate cancer is
Kate L Mahon
Kate L Mahon
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
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Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
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Susan M Henshall
Susan M Henshall
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
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Robert L Sutherland
Robert L Sutherland
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
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Lisa G Horvath
Lisa G Horvath
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
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Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
Department of Medical Oncology, University of Sydney, Cancer Research Program, Sydney Cancer Centre, Missenden Road, Camperdown, New South Wales 2050, Australia
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Introduction Prostate cancer causes substantial morbidity and mortality worldwide ( Ferlay et al . 2004 ) and is the second leading cause of cancer death in men in developed countries ( AIHW & AACR 2008 , Jemal et al . 2009 ). Metastatic prostate
Garrett Daniels
Garrett Daniels
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Yirong Li
Yirong Li
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Lan Lin Gellert
Lan Lin Gellert
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Albert Zhou
Albert Zhou
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Jonathan Melamed
Jonathan Melamed
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Xinyu Wu
Xinyu Wu
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Xinming Zhang
Xinming Zhang
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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David Zhang
David Zhang
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Daniel Meruelo
Daniel Meruelo
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Susan K Logan
Susan K Logan
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Ross Basch
Ross Basch
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Peng Lee
Peng Lee
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
Department of Pathology, Department of Pathology, NYU Cancer Institute, Department of Urology, Department of Pharmacology, New York Harbor Healthcare System, New York University School of Medicine, New York, New York, USA
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Introduction It has long been known that androgens are critical in the growth and progression of prostate cancer ( Dehm & Tindall 2006 ). Androgens signal through the androgen receptor (AR), a member of the steroid receptor family of transcription
