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Konsta Kukkonen Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Bryn Autio-Kimura Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Hanna Rauhala Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Juha Kesseli Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Matti Nykter Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Foundation for the Finnish Cancer Institute, Helsinki, Finland

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Leena Latonen Foundation for the Finnish Cancer Institute, Helsinki, Finland
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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Tapio Visakorpi Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Fimlab Laboratories Ltd, Tampere, Finland

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Introduction Prostate cancer (PCa) is a major cause of morbidity and mortality in the Western world ( Ferlay et al. 2019 ). With the aging of the population, the incidence of PCa is on the rise, increasing the burden on the health care

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K-M Rau
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H-Y Kang
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T-L Cha
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S A Miller
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M-C Hung
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, the most widely studied are breast cancer and prostate cancer. Apart from skin cancers, breast cancer and prostate cancer are the primary diagnosed cancer and secondary cause of cancer death in women and men, respectively, in the United States ( Jemal

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Su Jung Oh
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Holger H H Erb
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Alfred Hobisch Division of Experimental Urology, Department of Urology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Frédéric R Santer
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Zoran Culig
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Introduction Prostate cancer is the most common malignancy in Western countries and the second leading cause of cancer-related deaths in males ( Jemal et al . 2010 ). Patients diagnosed with localized disease can be cured by either surgery or

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Tianzhu Zang Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Mary-Ellen Taplin Harvard Medical School, Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Daniel Tamae Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Wanling Xie Department of Biostatistics and Computational Biology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Clementina Mesaros Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Systems Pharmacology & Translational Therapeutics, Center for Cancer Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Zhenwei Zhang Department of Biostatistics and Computational Biology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Glenn Bubley Beth Israel Deaconess Medical Center, Genitourinary Medical Oncology, Boston, Massachusetts, USA

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Bruce Montgomery Department of Medicine, University of Washington, Seattle, Washington, USA

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Steven P Balk Beth Israel Deaconess Medical Center, Genitourinary Medical Oncology, Boston, Massachusetts, USA

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Elahe A Mostaghel Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Ian A Blair Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Systems Pharmacology & Translational Therapeutics, Center for Cancer Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Systems Pharmacology & Translational Therapeutics, Center for Cancer Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Introduction Prostate cancer (CaP) is the most commonly diagnosed and the third leading cause of cancer death in males of the United States ( Siegel et al . 2017 ). Since the findings of Huggins and Hodges showed that castration could

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Ninu Poulose Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK

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Ian G Mills Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK

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Rebecca E Steele Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK

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Introduction: prostate and breast cancer Sex hormones act through nuclear hormone receptors and induce distinct transcriptional programmes essential to male and female physiology. They exert their effects on target tissues such as the mammary

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Arianna Ventura-Bahena Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav-IPN), Ciudad de México, Mexico

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Jesús Gibran Hernández-Pérez Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Mexico

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Luisa Torres-Sánchez Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Mexico

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Adolfo Sierra-Santoyo Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav-IPN), Ciudad de México, Mexico

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Derly Constanza Escobar-Wilches Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav-IPN), Ciudad de México, Mexico

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Consuelo Escamilla-Núñez Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Mexico

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Rocio Gómez Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav-IPN), Ciudad de México, Mexico

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Francisco Rodríguez-Covarrubias Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Servicio de Urología, Ciudad de México, Mexico

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Ma. de Lourdes López-González Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados Del Instituto Politécnico Nacional (Cinvestav-IPN), Ciudad de México, Mexico

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Mario Figueroa Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico

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. A non-canonical pathway focused on some adrenal-derived androgens with different biological activity has been described recently. These androgens, collectively known as 11-oxyandrogens, could be relevant in prostate cancer (PC) development and its

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S Nicholson
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J Waxman
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Varadha Balaji Venkadakrishnan Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA

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Salma Ben-Salem Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Hannelore V Heemers Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

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Introduction Prostate cancer (CaP) is expected to cause the death of 33,300 American men in 2020 and remains the second leading cause of cancer-related deaths in Western men ( Siegel et al. 2020 ). It is well recognized that the androgen

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Gianmarco Leone Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Marcello Tucci Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Consuelo Buttigliero Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Clizia Zichi Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Daniele Pignataro Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Paolo Bironzo Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Francesca Vignani Division of Medical Oncology, Ordine Mauriziano Hospital, Turin, Italy

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Giorgio V Scagliotti Division of Medical Oncology, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy

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Massimo Di Maio Division of Medical Oncology, Ordine Mauriziano Hospital, Turin, Italy

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Introduction In recent years, the treatment of patients with metastatic prostate cancer (PCa) has radically changed, with the availability of new antiandrogen hormonal therapies. However, this disease still remains a major health issue in the

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Petra Massoner
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Daniela Colleselli
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Andrea Matscheski Department of Urology, Institute for Biomedical Aging Research, Department of Molecular Pathophysiology of the Biocenter, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria

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Haymo Pircher Department of Urology, Institute for Biomedical Aging Research, Department of Molecular Pathophysiology of the Biocenter, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria

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Stephan Geley Department of Urology, Institute for Biomedical Aging Research, Department of Molecular Pathophysiology of the Biocenter, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria

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Pidder Jansen Dürr Department of Urology, Institute for Biomedical Aging Research, Department of Molecular Pathophysiology of the Biocenter, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria

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Helmut Klocker
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Introduction Prostate cancer is now the most frequently diagnosed cancer among men in Europe and the United States as well as a common cause of cancer death all over the world ( Parkin et al . 2005 , Jemal et al . 2008 ). A special feature of

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