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identifying novel therapeutic targets. It is for this reason that proteomics has become one of the most rapidly advancing fields in cancer research. Studying the expression and interactions of proteins in both normal and malignant tissues significantly
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Laboratory of Cancer Genetics, Veterans Affairs Medical Center, Digestive Diseases, and GI Developmental Biology, Department of Surgery, Medicine and Lombardi Cancer Center, Georgetown University Medical Center, Medical/Dental Building, NW 213, 3900 Reservoir Road, NW, Washington, District of Columbia 20007, USA
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et al . 1990 ). Mutational inactivation of TβRII represents one mechanism for the loss of TGF-β-mediated growth inhibition, which in many cases leads to the development of gastrointestinal cancer ( Arteaga et al . 1988 , 1993 , Kimchi et al . 1988
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Introduction Prostate cancer is a major cause of morbidity and mortality in men around the world, being the most common solid tumor. In America, ∼6 out of every 50 men over the age of 50 will be diagnosed with prostate cancer in his lifetime. In
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Introduction Improvements in the use of traditional breast cancer therapies have decreased the morbidity and mortality of breast cancer treatment, and improved the overall survival of women with early stage disease (American Cancer
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. 2011 ). Dietary, environmental, behavioral, and reproductive factors have been implicated in cancer gender disparity, but the molecular basis for this disparity is poorly understood. Thyroid cancer is one such cancer with a dramatically different
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Introduction Each year, over a million women worldwide are diagnosed with breast cancer, accounting for 25% of all female cancers. Treatments include surgery, radiation therapy, chemotherapy, or their combinations. Neoadjuvant chemotherapy is used
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Introduction Lethal clones of human cancer have the ability to adapt to hypoxic environments in primary or metastatic sites. Epigenetic and genetic mechanisms of adaptation to hypoxia, such as genetic instability, aerobic glycolysis
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, their aberrant expression and activity have been linked to a number of human diseases, including cancer ( Aletta & Hu 2008 ). PRMTs regulate transcription by functioning as co-activators for a range of transcription factors, including steroid
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Introduction Invasive breast cancer (IBC) is a heterogeneous disease, consisting of several molecular subtypes, all with a specific tumor biology and clinical outcome ( Perou et al. 2000 ). Each of these molecular subtypes, which are based
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Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Cancer Drug Discovery, Department of Molecular Biology and Biochemistry, Department of Environmental Health, MIMR-PHI Institute of Medical Research, PO BOX 5152, Clayton, Victoria 3168, Australia
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Introduction Normal growth and function of the mammary glands are dependent on the body's endocrine system. Many factors that influence breast cancer risk are therefore endocrine-associated processes, such as age at menopause, age at menarche