Search Results

You are looking at 141 - 150 of 384 items for :

  • "genetic alterations" x
  • Refine by access: All content x
Clear All
Debora Degl'Innocenti Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Debora Degl'Innocenti in
Google Scholar
PubMed
Close
,
Paola Romeo Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Paola Romeo in
Google Scholar
PubMed
Close
,
Eva Tarantino Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Eva Tarantino in
Google Scholar
PubMed
Close
,
Marialuisa Sensi Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine
Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Marialuisa Sensi in
Google Scholar
PubMed
Close
,
Giuliana Cassinelli Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Giuliana Cassinelli in
Google Scholar
PubMed
Close
,
Veronica Catalano Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Veronica Catalano in
Google Scholar
PubMed
Close
,
Cinzia Lanzi Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Cinzia Lanzi in
Google Scholar
PubMed
Close
,
Federica Perrone Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Federica Perrone in
Google Scholar
PubMed
Close
,
Silvana Pilotti Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Silvana Pilotti in
Google Scholar
PubMed
Close
,
Ettore Seregni Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Ettore Seregni in
Google Scholar
PubMed
Close
,
Marco A Pierotti Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Marco A Pierotti in
Google Scholar
PubMed
Close
,
Angela Greco Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Angela Greco in
Google Scholar
PubMed
Close
, and
Maria Grazia Borrello Molecular Mechanisms Unit, Nuclear Medicine Division, Scientific Directorate, Department of Experimental Oncology and Molecular Medicine

Search for other papers by Maria Grazia Borrello in
Google Scholar
PubMed
Close

thyroid tissues for a total of 13 non-neoplastic thyroids and 69 PTCs, including different subtypes. For both datasets, information about the genetic alteration of the neoplastic samples was available. In the first dataset, a cDNA array generated in our

Free access
Akiko Ebata Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan
Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Akiko Ebata in
Google Scholar
PubMed
Close
,
Takashi Suzuki Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Takashi Suzuki in
Google Scholar
PubMed
Close
,
Kiyoshi Takagi Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Kiyoshi Takagi in
Google Scholar
PubMed
Close
,
Yasuhiro Miki Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Yasuhiro Miki in
Google Scholar
PubMed
Close
,
Yoshiaki Onodera Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Yoshiaki Onodera in
Google Scholar
PubMed
Close
,
Yasuhiro Nakamura Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Yasuhiro Nakamura in
Google Scholar
PubMed
Close
,
Fumiyoshi Fujishima Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Fumiyoshi Fujishima in
Google Scholar
PubMed
Close
,
Kazuyuki Ishida Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Kazuyuki Ishida in
Google Scholar
PubMed
Close
,
Mika Watanabe Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Mika Watanabe in
Google Scholar
PubMed
Close
,
Kentaro Tamaki Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan
Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Kentaro Tamaki in
Google Scholar
PubMed
Close
,
Takanori Ishida Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Takanori Ishida in
Google Scholar
PubMed
Close
,
Noriaki Ohuchi Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Noriaki Ohuchi in
Google Scholar
PubMed
Close
, and
Hironobu Sasano Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan
Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Hironobu Sasano in
Google Scholar
PubMed
Close

lesions of atypical ductal hyperplasia (ADH), DCIS and IDC, and reported that genetic alterations accumulate during cancer progression from ADH to DCIS and finally to IDC ( Amari et al . 1999 ). However, several groups reported a close association of

Free access
Stéphanie Durand Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Stéphanie Durand in
Google Scholar
PubMed
Close
,
Carole Ferraro-Peyret Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Carole Ferraro-Peyret in
Google Scholar
PubMed
Close
,
Mireille Joufre Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Mireille Joufre in
Google Scholar
PubMed
Close
,
Annie Chave Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Annie Chave in
Google Scholar
PubMed
Close
,
Françoise Borson-Chazot Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Françoise Borson-Chazot in
Google Scholar
PubMed
Close
,
Samia Selmi-Ruby Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Samia Selmi-Ruby in
Google Scholar
PubMed
Close
, and
Bernard Rousset Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

Search for other papers by Bernard Rousset in
Google Scholar
PubMed
Close

another tyrosine kinase receptor) and different fusion partners leads to the expression of chimeric proteins with constitutive activity on different signaling cascades including the MAPK cascade. This genetic alteration has a low incidence in PTC

Free access
Nancy D Perrier Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Nancy D Perrier in
Google Scholar
PubMed
Close
,
Andrew Arnold Center for Molecular Oncology and Division of Endocrinology & Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut, USA

Search for other papers by Andrew Arnold in
Google Scholar
PubMed
Close
,
Jessica Costa-Guda Center for Regenerative Medicine & Skeletal Development, Center for Molecular Oncology, University of Connecticut School of Medicine/Dental Medicine, Farmington, Connecticut, USA

Search for other papers by Jessica Costa-Guda in
Google Scholar
PubMed
Close
,
Naifa L Busaidy Department of Endocrine Neoplasia & Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Naifa L Busaidy in
Google Scholar
PubMed
Close
,
Ha Nguyen Department of Medicine-Endocrinology, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Ha Nguyen in
Google Scholar
PubMed
Close
,
Hubert H Chuang Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Hubert H Chuang in
Google Scholar
PubMed
Close
, and
Maria Luisa Brandi Department of Endocrinology, University of Florence, Medical School, Florence, Italy

Search for other papers by Maria Luisa Brandi in
Google Scholar
PubMed
Close

specific genetic alterations and combinations thereof. Promising therapies can then be further tested in PDX models. Pathologic reporting Since pathology details are fundamental for appropriate cancer staging and treatment, the need for a standard

Free access
Young Shin Song Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea

Search for other papers by Young Shin Song in
Google Scholar
PubMed
Close
,
Seong-Keun Yoo Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea

Search for other papers by Seong-Keun Yoo in
Google Scholar
PubMed
Close
,
Hwan Hee Kim Center for Medical Innovation, Seoul National University Hospital, Seoul, Korea

Search for other papers by Hwan Hee Kim in
Google Scholar
PubMed
Close
,
Gyeongseo Jung Center for Medical Innovation, Seoul National University Hospital, Seoul, Korea

Search for other papers by Gyeongseo Jung in
Google Scholar
PubMed
Close
,
Ah-Reum Oh Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, GAIHST, Gachon University College of Medicine, Incheon, Korea

Search for other papers by Ah-Reum Oh in
Google Scholar
PubMed
Close
,
Ji-Young Cha Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, GAIHST, Gachon University College of Medicine, Incheon, Korea

Search for other papers by Ji-Young Cha in
Google Scholar
PubMed
Close
,
Su-jin Kim Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

Search for other papers by Su-jin Kim in
Google Scholar
PubMed
Close
,
Sun Wook Cho Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Search for other papers by Sun Wook Cho in
Google Scholar
PubMed
Close
,
Kyu Eun Lee Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

Search for other papers by Kyu Eun Lee in
Google Scholar
PubMed
Close
,
Jeong-Sun Seo Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea

Search for other papers by Jeong-Sun Seo in
Google Scholar
PubMed
Close
, and
Young Joo Park Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea
Center for Medical Innovation, Seoul National University Hospital, Seoul, Korea

Search for other papers by Young Joo Park in
Google Scholar
PubMed
Close

fusions were then excluded (Supplementary Table 1, see section on supplementary data given at the end of this article). The driver genetic alterations were defined as the significantly mutated genes and driver fusions, according to definitions in a TCGA

Free access
Yeon-Sook Choi Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Yeon-Sook Choi in
Google Scholar
PubMed
Close
,
Hyemi Kwon Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Search for other papers by Hyemi Kwon in
Google Scholar
PubMed
Close
,
Mi-Hyeon You Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Mi-Hyeon You in
Google Scholar
PubMed
Close
,
Tae Yong Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Tae Yong Kim in
Google Scholar
PubMed
Close
,
Won Bae Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Won Bae Kim in
Google Scholar
PubMed
Close
,
Young Kee Shong Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Young Kee Shong in
Google Scholar
PubMed
Close
,
Min Ji Jeon Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Min Ji Jeon in
Google Scholar
PubMed
Close
, and
Won Gu Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for other papers by Won Gu Kim in
Google Scholar
PubMed
Close

. 2005 , Kurata et al. 2016 , Subbiah et al. 2018 , Kim et al. 2020 , Lee & Park 2021 ). The BRAF V600E mutation is one of the common genetic alterations in ATC, accounting for 20–50% of cases ( Xing 2013 , Jeon et al. 2016 , Subbiah et al

Restricted access
Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

Search for other papers by Alfred King-yin Lam in
Google Scholar
PubMed
Close
and
Nassim Saremi Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

Search for other papers by Nassim Saremi in
Google Scholar
PubMed
Close

. Other than BRAFV600E -like tumours and RAS -like tumours, the other papillary thyroid carcinomas are labelled as non- BRAF –non- RAS tumours. They were seen with other genetic alterations such as EIF1AX ( eukaryotic translation initiation factor 1A

Free access
Maria Chiara Zatelli Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

Search for other papers by Maria Chiara Zatelli in
Google Scholar
PubMed
Close
,
Elia Guadagno Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

Search for other papers by Elia Guadagno in
Google Scholar
PubMed
Close
,
Erika Messina Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

Search for other papers by Erika Messina in
Google Scholar
PubMed
Close
,
Fabio Lo Calzo Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

Search for other papers by Fabio Lo Calzo in
Google Scholar
PubMed
Close
,
Antongiulio Faggiano Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

Search for other papers by Antongiulio Faggiano in
Google Scholar
PubMed
Close
,
Annamaria Colao Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

Search for other papers by Annamaria Colao in
Google Scholar
PubMed
Close
, and
NIKE Group
Search for other papers by NIKE Group in
Google Scholar
PubMed
Close

sporadic pancreatic NETs disclosed the presence of genetic alterations affecting DNA damage and repair, chromatin remodeling, telomere maintenance and mammalian target of rapamycin (mTOR) signaling ( Scarpa et al. 2017 ), providing a significant

Free access
Vanida A Serna Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA

Search for other papers by Vanida A Serna in
Google Scholar
PubMed
Close
,
Xin Wu Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA

Search for other papers by Xin Wu in
Google Scholar
PubMed
Close
,
Wenan Qiang Center for Developmental Therapeutics, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA
Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Search for other papers by Wenan Qiang in
Google Scholar
PubMed
Close
,
Justin Thomas Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA

Search for other papers by Justin Thomas in
Google Scholar
PubMed
Close
,
Michael L Blumenfeld Department of Obstetrics and Gynecology, Ohio State University, Columbus, Ohio, USA

Search for other papers by Michael L Blumenfeld in
Google Scholar
PubMed
Close
, and
Takeshi Kurita Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA

Search for other papers by Takeshi Kurita in
Google Scholar
PubMed
Close

al . 2014 , Wang et al . 2014 ). Recent comprehensive genome analyses identified four major LM subtypes with unique genetic alterations ( Mehine et al . 2013 , 2016 ), namely, MED12 mutant (MED12-LM) ( Mäkinen et al . 2011 ), HMGA2

Free access
Antonella Verrienti Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

Search for other papers by Antonella Verrienti in
Google Scholar
PubMed
Close
,
Giovanni Tallini Department of Medicine (DIMES), Anatomic Pathology-Molecular Diagnostic Unit AUSL of Bologna, University of Bologna School of Medicine, Bologna, Italy

Search for other papers by Giovanni Tallini in
Google Scholar
PubMed
Close
,
Chiara Colato Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

Search for other papers by Chiara Colato in
Google Scholar
PubMed
Close
,
Amélie Boichard Laboratoire de Recherche Translationnelle et, Centre de Ressources Biologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France

Search for other papers by Amélie Boichard in
Google Scholar
PubMed
Close
,
Saula Checquolo Laboratory of Molecular Pathology, Department of Medico-Surgical and Biotechnology, ‘Sapienza’ University of Rome, Latin, Italy

Search for other papers by Saula Checquolo in
Google Scholar
PubMed
Close
,
Valeria Pecce Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

Search for other papers by Valeria Pecce in
Google Scholar
PubMed
Close
,
Marialuisa Sponziello Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

Search for other papers by Marialuisa Sponziello in
Google Scholar
PubMed
Close
,
Francesca Rosignolo Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

Search for other papers by Francesca Rosignolo in
Google Scholar
PubMed
Close
,
Dario de Biase Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, Bologna, Italy

Search for other papers by Dario de Biase in
Google Scholar
PubMed
Close
,
Kerry Rhoden Department of Medicine (DIMEC), Medical Genetics Unit, University of Bologna School of Medicine, Bologna, Italy

Search for other papers by Kerry Rhoden in
Google Scholar
PubMed
Close
,
Gian Piero Casadei Anatomic Pathology Unit, AUSL di Bologna-Maggiore Hospital, Bologna, Italy

Search for other papers by Gian Piero Casadei in
Google Scholar
PubMed
Close
,
Diego Russo Department of Health Sciences, University of Catanzaro ‘Magna Graecia’, Catanzaro, Italy

Search for other papers by Diego Russo in
Google Scholar
PubMed
Close
,
Michela Visani Department of Medicine (DIMES), Anatomic Pathology-Molecular Diagnostic Unit AUSL of Bologna, University of Bologna School of Medicine, Bologna, Italy

Search for other papers by Michela Visani in
Google Scholar
PubMed
Close
,
Giorgia Acquaviva Department of Medicine (DIMES), Anatomic Pathology-Molecular Diagnostic Unit AUSL of Bologna, University of Bologna School of Medicine, Bologna, Italy

Search for other papers by Giorgia Acquaviva in
Google Scholar
PubMed
Close
,
Marco Ferdeghini Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy

Search for other papers by Marco Ferdeghini in
Google Scholar
PubMed
Close
,
Sebastiano Filetti Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

Search for other papers by Sebastiano Filetti in
Google Scholar
PubMed
Close
, and
Cosimo Durante Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

Search for other papers by Cosimo Durante in
Google Scholar
PubMed
Close

). Nevertheless, in a small proportion of sporadic MTCs, no genetic alterations are detected. Small-molecule inhibitors of receptor tyrosine kinases (TKIs) are one of the most promising approaches for treating MTCs. Indeed, encouraging results have emerged from

Free access