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Natalie Sampson Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Hannes Neuwirt Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Martin Puhr Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Helmut Klocker Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Iris E Eder Division of Experimental Urology, Department of Internal Medicine IV – Nephrology and Hypertensiology, Department of Urology

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Introduction Prostate cancer (PCa) is the most commonly diagnosed cancer in men and second leading cause of male cancer death in Western societies ( Siegel et al . 2012 ). Since the androgen dependence of PCa was discovered, intensive efforts have

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Ji Won Kim College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

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Dharmendra K Yadav Gachon Institute of Pharmaceutical Science & Department of Pharmacy, College of Pharmacy, Gachon University, Incheon, Republic of Korea
Department of Biochemistry, All India Institute of Medical Science, Jodhpur, India

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Soo Jin Kim College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

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Moo-Yeol Lee College of Pharmacy, Dongguk University, Goyang, Gyeonggi-do, Republic of Korea

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Jung-Min Park College of Pharmacy, Dongguk University, Goyang, Gyeonggi-do, Republic of Korea

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Bum Seok Kim College of Veterinary Medicine, Chonbuk National University, Iksan, Republic of Korea

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Mi-hyun Kim Gachon Institute of Pharmaceutical Science & Department of Pharmacy, College of Pharmacy, Gachon University, Incheon, Republic of Korea

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Hyeung-geun Park College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

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Keon Wook Kang College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

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. Prostate cancer (PCa) is one of the most common cancers and the second leading cause of male cancer-related death in the United States ( Siegel et al . 2011 ) and Europe ( Ferlay et al . 2010 ). Many treatment options, including prostatectomy, radiation

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Aruna V Krishnan Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5103, USA

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David Feldman Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5103, USA

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Introduction Prostate cancer (PCa) is the most commonly diagnosed malignancy in men after skin cancer and is a leading cause of cancer death in men in the United States ( Jemal et al . 2008 ). Surgery and radiation are common initial

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Claudio Festuccia
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Giovanni Luca Gravina Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Anna Maria D'Alessandro Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Paola Muzi
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Danilo Millimaggi Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Vincenza Dolo Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Enrico Ricevuto Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Carlo Vicentini Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Mauro Bologna Department of Experimental Medicine, Division of Radiotherapy, Department of Health Science, Division of Clinical Oncology, Department of Basic and Applied Biology, Chair of General Pathology, University of L'Aquila, Via Vetoio, Coppito-2, 67100 L'Aquila, Italy

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Introduction Prostate cancer represents a global public health problem. Worldwide, it is the second most common noncutaneous cancer in men, accounting for ∼10% of male cancers ( Haas et al . 2008 ). In recent years, 5 year survival rates for

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Dannah R Miller Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

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Matthew A Ingersoll Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA

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Ming-Fong Lin Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
Section of Urology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

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Introduction Prostate cancer (PCa), one of the most common solid tumors, remains the second leading cause of cancer-related death in US men with an estimated 174,650 new cases in 2019 ( Siegel et al. 2019 ). Early-stage localized PCa is well

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Hidewaki Nakagawa Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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Introduction Prostate cancer (PC) is the most common malignancy in men and the second leading cause of cancer-related deaths in Western countries. Incidence and mortality rates vary widely across geographic regions and ethnic groups ( Gronberg 2003

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Qu Deng Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA

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Dean G Tang Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA

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cellular heterogeneity and promotes tumor progression. For instance, genome-wide DNA sequencing of three individual prostate tumors revealed the existence of three or more clones within each cancer ( Cooper et al . 2015 ). Even morphologically normal

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Zsofia Kiss VA Northern California Health Care System, Mather, California, USA
Department of Urology, University of California at Davis, Sacramento, California, USA

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Paramita M Ghosh VA Northern California Health Care System, Mather, California, USA
Department of Urology, University of California at Davis, Sacramento, California, USA
Department of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, California, USA

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of DNA copy errors. Rodent studies showed that excessive androgen production can induce prostate cancer (CaP) ( Brown et al . 1979 ) and this was later supported by human studies that explored long-term exposure to high levels of androgens ( Gann et

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Takeshi Sasaki Department of Urology, Ise Red Cross Hospital, 471-2 Hunae 1-chome, Ise, Mie 516-8512, Japan

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Takehisa Onishi Department of Urology, Ise Red Cross Hospital, 471-2 Hunae 1-chome, Ise, Mie 516-8512, Japan

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Akira Hoshina Department of Urology, Ise Red Cross Hospital, 471-2 Hunae 1-chome, Ise, Mie 516-8512, Japan

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Introduction The standard initial systemic therapy for advanced prostate cancer (PC) is androgen deprivation therapy (ADT). Even PC patients with metastatic disease initially respond well to hormone therapy but then progress to castration

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Mark P Labrecque Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA

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Joshi J Alumkal Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA

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Ilsa M Coleman Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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Peter S Nelson Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA

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Colm Morrissey Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA

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Castration-resistant prostate cancer Prostate cancer (PC) is notable for the dependence of tumor cells on the androgen receptor (AR) for activation of a luminal differentiation program, proliferation and survival. Because of this, androgen

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