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Pedro Iglesias Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana (IDIPHISA), Majadahonda, Madrid, Spain

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Inmaculada Peiró Clinical Nutrition Unit, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain
Unit of Nutrition and Cancer-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain

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Betina Biagetti Department of Endocrinology, Universitari Vall d’Hebron, Barcelona, Spain

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Miguel Paja-Fano Department of Endocrinology, Hospital Universitario de Basurto, Bilbao, Spain

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Diana Ariadel Cobo Department of Endocrinology, Complejo Asistencial Universitario de León, León, Spain

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Carlos García Gómez Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain

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Manuel Mateu-Salat Department of Endocrinology, Hospital Sant Pau, Hospital Sant Pau, Barcelona, Spain
Department of Medicine/Endocrinology, IIB-Sant Pau, Research Center for Pituitary Diseases, Barcelona, Spain

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Idoia Genua Department of Endocrinology, Hospital Sant Pau, Hospital Sant Pau, Barcelona, Spain
Department of Medicine/Endocrinology, IIB-Sant Pau, Research Center for Pituitary Diseases, Barcelona, Spain

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Margarita Majem Department of Oncology, Hospital Sant Pau, Barcelona, Spain

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Mariona Riudavets Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France

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Javier Gavira Department of Oncology, Hospital Sant Pau, Barcelona, Spain

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Cristina Lamas Department of Endocrinology, Hospital General Universitario de Albacete, Albacete, Spain

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Antía Fernández Pombo Department of Endocrinology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain

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Fernando Guerrero-Pérez Department of Endocrinology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

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Carles Villabona Department of Endocrinology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

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José Manuel Cabezas Agrícola Department of Endocrinology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain

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Susan M Webb Department of Endocrinology, Hospital Sant Pau, Hospital Sant Pau, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Universitat Autònoma de Barcelona, Barcelona, Spain

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Juan J Díez Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana (IDIPHISA), Majadahonda, Madrid, Spain
Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain

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Introduction Checkpoint inhibitor immunotherapy has been shown to be an effective therapy in a wide variety of malignant tumors, such as advanced melanoma, renal carcinoma, non-small cell lung cancer, head and neck cancer, urothelial carcinoma

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-21-0228
Volume/Issue:
Volume 28: Issue 12
Restricted access
Callum Livingstone Peptide Hormones Supraregional Assay Service (SAS), Faculty of Health and Medical Sciences, Clinical Biochemistry Department, Royal Surrey County Hospital NHS Trust, Guildford, Surrey GU2 7XX, UK
Peptide Hormones Supraregional Assay Service (SAS), Faculty of Health and Medical Sciences, Clinical Biochemistry Department, Royal Surrey County Hospital NHS Trust, Guildford, Surrey GU2 7XX, UK

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significant advances in recent years. The purpose of this review is to provide the reader with a perspective and update on IGF2, with respect to its role in cancer and clinical utility for its measurement. The IGFs are part of a complex system, the components

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Review Article
DOI:
https://doi.org/10.1530/ERC-13-0231
Volume/Issue:
Volume 20: Issue 6
Free access
Sock Hoai Chan Division of Medical Oncology, Cancer Genetics Service, National Cancer Centre Singapore, Singapore

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Joanne Ngeow Division of Medical Oncology, Cancer Genetics Service, National Cancer Centre Singapore, Singapore
Oncology Academic Clinical Program, Duke-NUS Medical School Singapore, Singapore

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Introduction Genomic instability is a hallmark of human cancers ( Negrini et al. 2010 ). It refers to the increased frequency of accruing genetic alterations, ranging from single nucleotide mutations to whole chromosome changes such as

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Review Article
DOI:
https://doi.org/10.1530/ERC-17-0062
Volume/Issue:
Volume 24: Issue 9
Free access
David L Vesely Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine, Molecular Pharmacology and Physiology, James A. Haley VA Medical Center-151, University of South Florida Cardiac Hormone Center, and University of South Florida Morsani School of Medicine, 13000 Bruce B. Downs Boulevard, Tampa, Florida 33612, USA

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2003 , Cataliotti & Burnett 2005 ). When these four cardiac hormones synthesized by the ANP prohormone gene are given in concentrations higher than those synthesized by the heart, they have anticancer effects on human pancreatic cancers growing in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0054
Volume/Issue:
Volume 20: Issue 3
Free access
Massimo Terzolo Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy

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Giuseppe Reimondo Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy

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Paola Berchialla Statistical Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy

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Emanuele Ferrante Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Elena Malchiodi Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Laura De Marinis Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy

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Rosario Pivonello Division of Endocrinology, Department of Clinical Medicine and Surgery, University Federico II di Napoli, Naples, Italy

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Silvia Grottoli Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, ASOU Città della Salute e della Scienza, Turin, Italy

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Marco Losa Pituitary Unit, Department of Neurosurgery, San Raffaele Scientific Institute, University ‘Vita- Salute’, Milan, Italy

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Salvatore Cannavo Department of Clinical and Experimental Medicine-Endocrinology Unit, University of Messina, Messina, Italy

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Diego Ferone Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DiMI), Center of Excellence for Biomedical Research (CEBR) IRCCS, AOU San Martino-IST, San Martino Hospital, University of Genova, Genova, Italy

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Marcella Montini Ambulatori di Endocrinologia, Humanitas Gavazzeni, Bergamo, Italy

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Marta Bondanelli Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy

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Ernesto De Menis Internal Medicine, San Valentino Hospital, Montebelluna, Treviso, Italy

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Chiara Martini Internal Medicine, Department of Medicine, DIMED, University of Padova, Padova, Italy

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Efisio Puxeddu Department of Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy

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Antonino Velardo Department of Internal Medicine, Section of Endocrinology and Metabolism, University of Modena, Modena, Italy

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Alessandro Peri Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Marco Faustini-Fustini IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy

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Patrizia Tita Endocrinology, AO Garibaldi-Nesima, Catania, Italy

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Francesca Pigliaru Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy

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Giulia Peraga Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy

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Giorgio Borretta Division of Endocrinology and Metabolism, Santa Croce and Carle Hospital, Cuneo, Italy

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Carla Scaroni Endocrinology Unit, Department of Medicine, DIMED University of Padua, Padua, Italy

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Nicoletta Bazzoni Endocrinology, Sant’Antonio Abate Hospital, Gallarate, Varese, Italy

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Antonio Bianchi Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy

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Alessandro Berton Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, ASOU Città della Salute e della Scienza, Turin, Italy

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Andreea Liliana Serban Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Roberto Baldelli Endocrinology Unit A.O. San Camillo - Forlanini, Rome, Italy

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Letizia Maria Fatti Division of Endocrine and Metabolic Diseases, San Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy

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Annamaria Colao Division of Endocrinology, Department of Clinical Medicine and Surgery, University Federico II di Napoli, Naples, Italy

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Maura Arosio Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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for the Italian Study Group of Acromegaly
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Italian patients and found that vascular disease and cancer were the main causes of death. Mortality was higher in patients with persistently active disease, and IGF1 levels at diagnosis, GH at the last follow-up, cancer and pituitary radiotherapy were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0553
Volume/Issue:
Volume 24: Issue 9
Free access
Annemiek Walenkamp
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Guillermo Crespo Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Felipe Fierro Maya Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Reidar Fossmark Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Peter Igaz Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Anja Rinke Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Gianluca Tamagno Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Giovanni Vitale Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Kjell Öberg Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Tim Meyer Department of Medical Oncology, Department of Medical Oncology, Department of Endocrine Oncology, Department of Cancer Research and Molecular Medicine, 2nd Department of Medicine, Department of Gastroenterology, Department of General Internal Medicine, Department of Clinical Sciences and Community Health (DISCCO), Laboratory of Endocrine and Metabolic Research, Department of Endocrine Oncology, UCL Cancer Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

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Introduction Neuroendocrine tumours (NETs) are diverse in their site of origin and clinical behaviour, ranging from highly aggressive small cell cancers of the lung to indolent, low-grade tumours of the small bowel ( Yao et al . 2008 a ). Symptoms

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0106
Volume/Issue:
Volume 21: Issue 6
Free access
Jaime Guevara-Aguirre Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador
Instituto de Endocrinología IEMYR, Quito, Ecuador
Maastricht University, Maastricht, The Netherlands

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Gabriela Peña Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Gabriel Pazmiño Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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William Acosta Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Jannette Saavedra Instituto de Endocrinología IEMYR, Quito, Ecuador

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Daniela Lescano Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Alexandra Guevara Instituto de Endocrinología IEMYR, Quito, Ecuador

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Antonio W D Gavilanes Maastricht University, Maastricht, The Netherlands

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incidence of cancer despite obesity as a risk factor. As noted, while the most striking clinical association observed in the ELS subjects is that of obesity and low T2D incidence, the diminished incidence of malignancies despite the risk factor posed by

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Review Article
Collections:
Growth Hormone in Endocrine Cancers
DOI:
https://doi.org/10.1530/ERC-22-0389
Volume/Issue:
Volume 30: Issue 6
Free access
James F H Pittaway Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Constantinos Lipsos Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Katia Mariniello Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Leonardo Guasti Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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with differential expression in small cell lung cancer cell lines. Structural analysis of the protein revealed it was highly homologous with the proteins Delta , Serrate and Notch from Drosophila melanogaster and it was termed ‘human Delta

Article Type:
Review Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0208
Volume/Issue:
Volume 28: Issue 12
Free access
Francesca Ruggieri Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Katharina Jonas Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Manuela Ferracin Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

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Michael Dengler Division of Oncology, Medical University of Graz, Graz, Austria

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Vanessa Jӓger Division of Oncology, Medical University of Graz, Graz, Austria

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Martin Pichler Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria
Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany
Translational Oncology, University Hospital of Augsburg, Augsburg, Germany

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Introduction At the beginning of the twenty-first century, Hanahan and Weinberg described some essential capabilities (hallmarks of cancer) which tumor cells have to acquire and which collectively drive malignant growth ( Hanahan & Weinberg

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Review Article
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100 Years of the Warburg Effect and Endocrine Cancer
DOI:
https://doi.org/10.1530/ERC-22-0267
Volume/Issue:
Volume 30: Issue 8
Free access
Antonio De la Vieja Tumor Endocrine Unit, Chronic Disease Program (UFIEC), Instituto de Salud Carlos III, Madrid, Spain
CiberOnc, Instituto de Salud Carlos III, Madrid, Spain

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Pilar Santisteban CiberOnc, Instituto de Salud Carlos III, Madrid, Spain
Department of Physiopathology of Endocrine a Nervous System, Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain

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thyroid dysfunction and thyroid cancer ( Pfinder et al . 2016 ). On the other hand, radioactive iodine (RAI) therapy with 131 I has been the cornerstone adjuvant therapy for the treatment of thyroid cancer for decades ( Seidlin et al . 1946 ), with

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0515
Volume/Issue:
Volume 25: Issue 4
Free access