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Chiara Verdelli Laboratory of Experimental Endocrinology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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Irene Forno Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Division of Pathology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

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Annamaria Morotti Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Division of Pathology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

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Pasquale Creo Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy

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Vito Guarnieri Medical Genetics, IRCCS Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy

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Alfredo Scillitani Endocrine Unit, IRCCS Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy

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Filomena Cetani Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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Leonardo Vicentini Endocrine Surgery, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

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Gianni Balza Endocrinology Unit, Ospedale Manzoni, Lecco, Italy

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Edoardo Beretta Endocrine Surgery, IRCCS Ospedale San Raffaele, Milan, Italy

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Stefano Ferrero Division of Pathology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

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Valentina Vaira Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Division of Pathology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

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Sabrina Corbetta Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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elucidated and alternative treatments to surgery are limited. Similar to what was observed in most human cancers, microRNAs have been shown to be involved in parathyroid tumorigenesis ( Corbetta et al. 2010 , Vaira et al. 2016 ). Indeed, we previously

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0204
Volume/Issue:
Volume 25: Issue 7
Free access
Zhenying Guo Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

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Heather Hardin Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

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Ricardo V Lloyd Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

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EGFR and cMET . MicroRNAs have regulatory roles during EMT and during the reversal of MET to EMT. With subsequent colonization a secondary tumor becomes apparent clinically as a macrometastasis in the lung. Studies with primary PTCs using gene

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0002
Volume/Issue:
Volume 21: Issue 5
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Francesca Ruggieri Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Katharina Jonas Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Manuela Ferracin Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

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Michael Dengler Division of Oncology, Medical University of Graz, Graz, Austria

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Vanessa Jӓger Division of Oncology, Medical University of Graz, Graz, Austria

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Martin Pichler Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria
Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany
Translational Oncology, University Hospital of Augsburg, Augsburg, Germany

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). MicroRNAs (miRNAs), small interfering RNAs, small nuclear RNAs, small nucleolar RNAs, Piwi-interacting RNAs, and tRNA-derived small RNAs are all classified as sncRNAs ( Watson et al. 2019 ). Until some years ago, the vast majority of the human genome was

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Review Article
Collections:
100 Years of the Warburg Effect and Endocrine Cancer
DOI:
https://doi.org/10.1530/ERC-22-0267
Volume/Issue:
Volume 30: Issue 8
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P Pallante
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R Visone
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M Ferracin
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A Ferraro
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M T Berlingieri
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G Troncone
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G Chiappetta
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C G Liu
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M Santoro
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M Negrini
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C M Croce
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A Fusco
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Introduction MicroRNAs (miRNAs) represent a class of endogenous, small, non-coding but functional RNAs of 19–23 nt cleaved from larger hairpin precursors ( Bartel 2004 ). They comprise one of the most abundant classes of gene

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01209
Volume/Issue:
Volume 13: Issue 2
Free access
Libero Santarpia Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of
Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of

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Milena Nicoloso Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of

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George A Calin Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of

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miRs and gene regulation MicroRNAs (miRNAs or miRs) are a small (20–23 nucleotides), highly conserved noncoding class of regulatory RNA molecules expressed in a tissue- and development-specific manner ( Ambros 2008 ). miRs are excised from a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0222
Volume/Issue:
Volume 17: Issue 1
Free access
Luke A Selth Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia

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Lisa M Butler Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia

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Micromanagers of gene expression MicroRNAs (miRNAs) are small nonprotein-coding RNA molecules that act to regulate gene expression. The genes encoding miRNAs are, in general, regulated and transcribed in the same manner as protein-coding genes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0010
Volume/Issue:
Volume 19: Issue 4
Free access
Pierlorenzo Pallante Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Rosa Visone Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Carlo Maria Croce Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Biotecnologie Avanzate-Napoli, Department of Molecular Virology, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli ‘Federico II’, Via Pansini 5, 80131 Napoli, Italy

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). Moreover, mutations of CTNNB1 (β-catenin) have been found in 25% of PDTCs and in 66% of ATCs ( Garcia-Rostan et al . 2001 , Miyake et al . 2001 ; Table 1 ). MicroRNAs (miRNAs or miRs) constitute a class of small endogenous noncoding RNAs of 19

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0217
Volume/Issue:
Volume 17: Issue 1
Free access
S Corbetta
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V Vaira Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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V Guarnieri Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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A Scillitani Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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C Eller-Vainicher Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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S Ferrero Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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L Vicentini Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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I Chiodini Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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M Bisceglia Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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P Beck-Peccoz Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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S Bosari Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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A Spada Endocrinology and Diabetology Unit, Pathology Unit, Unit of Medical Genetics, Unit of Endocrinology, Endocrine Unit, Endocrine Surgery, Unit of Pathology, Department of Medical-Surgical Sciences, Università di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy

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adenomatous and carcinomatous parathyroid lesions ( Cetani et al . 2007 , Juhlin et al . 2007 ). Nonetheless, pathogenesis of PaC is still uncertain and its diagnosis remains a clinical challenge. MicroRNAs (miRNAs or miRs) are small non-coding RNAs

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0134
Volume/Issue:
Volume 17: Issue 1
Free access
Patsy Soon Cancer Genetics, Department of Surgery, Department of Biochemistry, Hormones and Cancer, Kolling Institute of Medical Research, University of Sydney, Level 9, Kolling Building, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
Cancer Genetics, Department of Surgery, Department of Biochemistry, Hormones and Cancer, Kolling Institute of Medical Research, University of Sydney, Level 9, Kolling Building, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia

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Hippokratis Kiaris Cancer Genetics, Department of Surgery, Department of Biochemistry, Hormones and Cancer, Kolling Institute of Medical Research, University of Sydney, Level 9, Kolling Building, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia

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microRNAs (miRNAs) have emerged as major regulators of this paracrine activity and of the transition of the fibroblasts into the cancer-associated state. As discussed later, miR-21 ( Yao et al . 2011 ), miR-31, -214 and -155 ( Mitra et al . 2012 ) appear

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0119
Volume/Issue:
Volume 20: Issue 5
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Kreepa G Kooblall OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Victoria J Stokes OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Omair A Shariq OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Katherine A English OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Mark Stevenson OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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John Broxholme Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Benjamin Wright Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Helen E Lockstone Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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David Buck Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK

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Simona Grozinsky-Glasberg Neuroendocrine Tumor Unit, ENETS Center of Excellence, Endocrinology & Metabolism Department, Hadassah Medical Center and Faculty of Medicine, The Hebrew University of Jerusalem, Israel

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Christopher J Yates OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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Rajesh V Thakker OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK

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Kate E Lines OCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK

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://doi.org/10.1093/bioinformatics/btu638 ) Ardekani AM Naeini MM 2010 The role of microRNAs in human diseases . Avicenna Journal of Medical Biotechnology 2 161 – 179 . Avniel-Polak S Leibowitz G Riahi Y Glaser B Gross DJ Grozinsky-Glasberg S

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0045
Volume/Issue:
Volume 29: Issue 10
Open access