Search Results

You are looking at 11 - 20 of 431 items for :

  • "oestrogen" x
  • Refine by access: All content x
Clear All
Edward B Alabraba
Search for other papers by Edward B Alabraba in
Google Scholar
PubMed
Close
,
Philippe Taniere Liver Research Group, Department of Pathology,, Endocrine Research Group,, Liver Unit,, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Philippe Taniere in
Google Scholar
PubMed
Close
,
Gary M Reynolds
Search for other papers by Gary M Reynolds in
Google Scholar
PubMed
Close
,
Paul M Stewart Liver Research Group, Department of Pathology,, Endocrine Research Group,, Liver Unit,, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Paul M Stewart in
Google Scholar
PubMed
Close
,
Stephen J Wigmore
Search for other papers by Stephen J Wigmore in
Google Scholar
PubMed
Close
, and
Simon R Bramhall Liver Research Group, Department of Pathology,, Endocrine Research Group,, Liver Unit,, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Simon R Bramhall in
Google Scholar
PubMed
Close

confined to endocrine pancreas tissue ( Doglioni et al . 1990 , Viale et al . 1992 ). A decade ago, oestrogen receptor (ER) presence was demonstrated in pancreatic tumour tissue using radioligand binding assays and Scatchard analysis ( Greenway et al

Free access
R I Nicholson Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by R I Nicholson in
Google Scholar
PubMed
Close
,
I R Hutcheson Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by I R Hutcheson in
Google Scholar
PubMed
Close
,
S E Hiscox Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by S E Hiscox in
Google Scholar
PubMed
Close
,
J M Knowlden Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by J M Knowlden in
Google Scholar
PubMed
Close
,
M Giles Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by M Giles in
Google Scholar
PubMed
Close
,
D Barrow Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by D Barrow in
Google Scholar
PubMed
Close
, and
J M W Gee Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK

Search for other papers by J M W Gee in
Google Scholar
PubMed
Close

Introduction In oestrogen-sensitive breast cancer cells, it is widely believed that locally and distally produced growth factors engage intracellular signalling pathways that productively cross-talk with oestrogen receptor (ER

Free access
Charline Dubois Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Charline Dubois in
Google Scholar
PubMed
Close
,
Natacha Rocks Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Natacha Rocks in
Google Scholar
PubMed
Close
,
Silvia Blacher Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Silvia Blacher in
Google Scholar
PubMed
Close
,
Irina Primac Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Irina Primac in
Google Scholar
PubMed
Close
,
Anne Gallez Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Anne Gallez in
Google Scholar
PubMed
Close
,
Melissa García-Caballero Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Melissa García-Caballero in
Google Scholar
PubMed
Close
,
Céline Gérard Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Céline Gérard in
Google Scholar
PubMed
Close
,
Laurent Brouchet Thoracic Surgery Department, University Hospital CHU Toulouse, Toulouse, France

Search for other papers by Laurent Brouchet in
Google Scholar
PubMed
Close
,
Agnès Noël Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Agnès Noël in
Google Scholar
PubMed
Close
,
Françoise Lenfant INSERM UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires – I2MC, University of Toulouse III Paul Sabatier, UPS, Toulouse, France

Search for other papers by Françoise Lenfant in
Google Scholar
PubMed
Close
,
Didier Cataldo Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Didier Cataldo in
Google Scholar
PubMed
Close
, and
Christel Pequeux Laboratory of Tumour and Development Biology, GIGA-Cancer, University of Liège, CHU-B23, Liège, Belgium

Search for other papers by Christel Pequeux in
Google Scholar
PubMed
Close

contribution of oestrogens to lung cancer development ( Siegfried & Stabile 2014 , Rodriguez-Lara et al . 2018 ). Indeed, elevated 17b-oestradiol (E2) levels and higher expression of aromatase predict lower overall survival in lung cancer patients ( Mah et

Free access
A Howell
Search for other papers by A Howell in
Google Scholar
PubMed
Close
,
R B Clarke
Search for other papers by R B Clarke in
Google Scholar
PubMed
Close
, and
E Anderson
Search for other papers by E Anderson in
Google Scholar
PubMed
Close
Restricted access
L-A Martin
Search for other papers by L-A Martin in
Google Scholar
PubMed
Close
,
S Pancholi
Search for other papers by S Pancholi in
Google Scholar
PubMed
Close
,
C M W Chan
Search for other papers by C M W Chan in
Google Scholar
PubMed
Close
,
I Farmer
Search for other papers by I Farmer in
Google Scholar
PubMed
Close
,
C Kimberley
Search for other papers by C Kimberley in
Google Scholar
PubMed
Close
,
M Dowsett
Search for other papers by M Dowsett in
Google Scholar
PubMed
Close
, and
S R D Johnston
Search for other papers by S R D Johnston in
Google Scholar
PubMed
Close

Introduction Most patients with oestrogen receptor (ER)-positive advanced breast cancer who have relapsed on tamoxifen (TAM) are prescribed aromatase inhibitors. Unlike TAM, which competes with oestrogen for the ER, aromatase

Free access
R Kaaks
Search for other papers by R Kaaks in
Google Scholar
PubMed
Close
,
S Rinaldi
Search for other papers by S Rinaldi in
Google Scholar
PubMed
Close
,
T J Key
Search for other papers by T J Key in
Google Scholar
PubMed
Close
,
F Berrino
Search for other papers by F Berrino in
Google Scholar
PubMed
Close
,
P H M Peeters
Search for other papers by P H M Peeters in
Google Scholar
PubMed
Close
,
C Biessy
Search for other papers by C Biessy in
Google Scholar
PubMed
Close
,
L Dossus
Search for other papers by L Dossus in
Google Scholar
PubMed
Close
,
A Lukanova
Search for other papers by A Lukanova in
Google Scholar
PubMed
Close
,
S Bingham
Search for other papers by S Bingham in
Google Scholar
PubMed
Close
,
K-T Khaw
Search for other papers by K-T Khaw in
Google Scholar
PubMed
Close
,
N E Allen
Search for other papers by N E Allen in
Google Scholar
PubMed
Close
,
H B Bueno-de-Mesquita
Search for other papers by H B Bueno-de-Mesquita in
Google Scholar
PubMed
Close
,
C H van Gils
Search for other papers by C H van Gils in
Google Scholar
PubMed
Close
,
D Grobbee
Search for other papers by D Grobbee in
Google Scholar
PubMed
Close
,
H Boeing
Search for other papers by H Boeing in
Google Scholar
PubMed
Close
,
P H Lahmann
Search for other papers by P H Lahmann in
Google Scholar
PubMed
Close
,
G Nagel
Search for other papers by G Nagel in
Google Scholar
PubMed
Close
,
J Chang-Claude
Search for other papers by J Chang-Claude in
Google Scholar
PubMed
Close
,
F Clavel-Chapelon
Search for other papers by F Clavel-Chapelon in
Google Scholar
PubMed
Close
,
A Fournier
Search for other papers by A Fournier in
Google Scholar
PubMed
Close
,
A Thiébaut
Search for other papers by A Thiébaut in
Google Scholar
PubMed
Close
,
C A González
Search for other papers by C A González in
Google Scholar
PubMed
Close
,
J R Quirós
Search for other papers by J R Quirós in
Google Scholar
PubMed
Close
,
M-J Tormo
Search for other papers by M-J Tormo in
Google Scholar
PubMed
Close
,
E Ardanaz
Search for other papers by E Ardanaz in
Google Scholar
PubMed
Close
,
P Amiano
Search for other papers by P Amiano in
Google Scholar
PubMed
Close
,
V Krogh
Search for other papers by V Krogh in
Google Scholar
PubMed
Close
,
D Palli
Search for other papers by D Palli in
Google Scholar
PubMed
Close
,
S Panico
Search for other papers by S Panico in
Google Scholar
PubMed
Close
,
R Tumino
Search for other papers by R Tumino in
Google Scholar
PubMed
Close
,
P Vineis
Search for other papers by P Vineis in
Google Scholar
PubMed
Close
,
A Trichopoulou
Search for other papers by A Trichopoulou in
Google Scholar
PubMed
Close
,
V Kalapothaki
Search for other papers by V Kalapothaki in
Google Scholar
PubMed
Close
,
D Trichopoulos
Search for other papers by D Trichopoulos in
Google Scholar
PubMed
Close
,
P Ferrari
Search for other papers by P Ferrari in
Google Scholar
PubMed
Close
,
T Norat
Search for other papers by T Norat in
Google Scholar
PubMed
Close
,
R Saracci
Search for other papers by R Saracci in
Google Scholar
PubMed
Close
, and
E Riboli
Search for other papers by E Riboli in
Google Scholar
PubMed
Close

interpreted as being the result of a longer lifetime exposure to elevated sex steroids, particularly oestrogens, which may inhibit apoptosis and stimulate proliferation of the mammary duct epithelium ( Pike et al . 1993 , Key et al . 2001 ). Finally, among

Free access
Alison J Butt
Search for other papers by Alison J Butt in
Google Scholar
PubMed
Close
,
Catriona M McNeil
Search for other papers by Catriona M McNeil in
Google Scholar
PubMed
Close
,
Elizabeth A Musgrove
Search for other papers by Elizabeth A Musgrove in
Google Scholar
PubMed
Close
, and
Robert L Sutherland
Search for other papers by Robert L Sutherland in
Google Scholar
PubMed
Close

disease. A major issue for the development of novel endocrine therapies is that, although oestrogen has been implicated as a major etiological factor in the tumorigenic process in the breast, the downstream effects of its actions remain to be fully

Free access
Frances Collins The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

Search for other papers by Frances Collins in
Google Scholar
PubMed
Close
,
Nozomi Itani The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

Search for other papers by Nozomi Itani in
Google Scholar
PubMed
Close
,
Arantza Esnal-Zufiaurre The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

Search for other papers by Arantza Esnal-Zufiaurre in
Google Scholar
PubMed
Close
,
Douglas A Gibson The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

Search for other papers by Douglas A Gibson in
Google Scholar
PubMed
Close
,
Carol Fitzgerald The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

Search for other papers by Carol Fitzgerald in
Google Scholar
PubMed
Close
, and
Philippa T K Saunders The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

Search for other papers by Philippa T K Saunders in
Google Scholar
PubMed
Close

changing demographics characterized by an aging population and increased prevalence of obesity ( Sanderson et al. 2017 ). Clinically, endometrial cancers are routinely classified as having a type I or type II phenotype, with the former being oestrogen

Open access
Leigh C Murphy
Search for other papers by Leigh C Murphy in
Google Scholar
PubMed
Close
and
Peter H Watson
Search for other papers by Peter H Watson in
Google Scholar
PubMed
Close

Introduction Oestrogens are pivotal in the growth and development of both normal and neoplastic mammary tissues ( Kelsey 1993 ), and mediate most of their action via ligand-dependent transcription factors called oestrogen receptors

Free access
Georgios P Skliris Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine

Search for other papers by Georgios P Skliris in
Google Scholar
PubMed
Close
,
Zoann J Nugent Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine

Search for other papers by Zoann J Nugent in
Google Scholar
PubMed
Close
,
Brian G Rowan Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine

Search for other papers by Brian G Rowan in
Google Scholar
PubMed
Close
,
Carla R Penner Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine

Search for other papers by Carla R Penner in
Google Scholar
PubMed
Close
,
Peter H Watson Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine

Search for other papers by Peter H Watson in
Google Scholar
PubMed
Close
, and
Leigh C Murphy Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, Department of Structural and Cellular Biology, Manitoba Breast Tumour Bank, Tumour Tissue Repository and Deeley Research Centre, Faculty of Medicine

Search for other papers by Leigh C Murphy in
Google Scholar
PubMed
Close

Introduction Oestrogen receptor (ERα) status of breast tumours is an imperfect marker of endocrine therapy response ( Osborne 1998 a , b ), and there is a need for more precise biomarkers of treatment response. ERα is regulated by post

Free access