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Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
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tumour cell-intrinsic pathways to bolster anti-tumour immunity and overcome chemo-/radioresistance afforded by PTEN deficiency in PCa. Prostate tumours additionally partake in crosstalk with their encapsulating stroma in order to remodel the TME and
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alongside NFκB1 in our MCF-7 cells. NFκB signalling has again been implicated substantially in promoting cell survival/proliferation under conditions of environmental stress, in chemo/radioresistance ( Wu & Kral 2005 ) and furthermore in ER+/ER− resistance
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125 –129. Liang K , Ang KK, Milas L, Hunter N & Fan Z 2003 The epidermal growth factor receptor mediates radioresistance. International Journal of Radiation Oncology, Biology and Physics 57 246 –254
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PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response . Radiotherapy and Oncology 108 415 – 421 . ( doi:10.1016/j.radonc.2013.06.037 ). Namgoong GM Khanal P Cho HG Lim SC Oh YK Kang BS
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Department of Anatomic Pathology, Department of Gene Expression Regulation, Department of Pathology and Histotechnology, Department of Pathology, Department of Surgical Oncology, Department of Surgery, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
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Yegnasubramanian S Esopi D Kombairaju P Bodas M Wu H Bova SG Biswal S 2010 Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth . Molecular Cancer
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that CD44, especially CD44v isoforms, are critical players in regulating the properties of stem-like cancer cells including self-renewal, tumor initiation, metastasis, and chemo/radioresistance. Significantly, CD44 has been identified as a typical stem
Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Chang Gung University, Taoyuan, Taiwan
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A Zhang X Vedaie M Saji M Jhiang S Ringel MD 2019 Inhibiting BRAF oncogene-mediated radioresistance effectively radiosensitizes BRAF(V600E)-mutant thyroid cancer cells by constraining DNA double-strand break repair . Clinical Cancer
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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new tumors in ATC. CSCs are a subpopulation of cells in tumors that share molecular similarities to embryonic or adult stem cells and are frequently related to chemo- and radio-resistance ( Reya et al . 2001 , Lin 2011 ). A previous study reported
Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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Cancer Genetics, Department of Endocrinology, Kolling Institute of Medical Research
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-radiation contributes to the radioresistance of glioma stem cells . International Journal of Cancer 125 717 – 722 . ( doi:10.1002/ijc.24402 ). Lu Z Luo RZ Lu Y Zhang X Yu Q Khare S Kondo S Kondo Y Yu Y Mills GB 2008 The tumor suppressor
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et al . 2008 ). The aggressive pathology of ATC may be further explained by the presence of self-renewing cancer stem cells ( Yun et al . 2014 ); a small population of cells in the tumor that can promote tumor chemo- and radioresistance and lead to