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Lauren N Pontius
Lauren N Pontius
Duke University Medical Center, Durham, North Carolina, USA
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Linda M Youngwirth
Linda M Youngwirth
Duke University Medical Center, Durham, North Carolina, USA
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Samantha M Thomas
Samantha M Thomas
Duke University Medical Center, Durham, North Carolina, USA
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Randall P Scheri
Randall P Scheri
Duke University Medical Center, Durham, North Carolina, USA
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Sanziana A Roman
Sanziana A Roman
Duke University Medical Center, Durham, North Carolina, USA
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Julie A Sosa
Julie A Sosa
Duke University Medical Center, Durham, North Carolina, USA
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institution, and comorbidity score. Annual income levels were assigned by the NCDB by linking a patient’s zip code to the U.S. Census data for the year 2000. Comorbidity was represented by the modified Charlson/Deyo scoring system ( Deyo et al. 1992
P S H Soon
P S H Soon
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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A J Gill
A J Gill
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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D E Benn
D E Benn
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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A Clarkson
A Clarkson
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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B G Robinson
B G Robinson
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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K L McDonald
K L McDonald
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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S B Sidhu
S B Sidhu
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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Cancer Genetics, Department of Surgery, Anatomical Pathology, Endocrinology, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, Sydney, New South Wales 2065, Australia
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) can be difficult. The Weiss score, a nine-point histopathological scoring system, is presently the most widely used system for classifying adrenocortical tumors (ACTs) as benign or malignant. A total score of ≤2 is typically associated with a benign
Bertrand Brieau
Bertrand Brieau
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Olivia Hentic
Olivia Hentic
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Rachida Lebtahi
Rachida Lebtahi
Service de médecine nucléaire, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Maxime Palazzo
Maxime Palazzo
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Makrem Ben Reguiga
Makrem Ben Reguiga
Département de pharmacie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Vinciane Rebours
Vinciane Rebours
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Frederique Maire
Frederique Maire
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Pascal Hammel
Pascal Hammel
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Philippe Ruszniewski
Philippe Ruszniewski
Service de gastro-entérologie et pancréatologie, Hôpital Beaujon, AP-HP, Université Paris Diderot, Clichy, France
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Pierre Fenaux
Pierre Fenaux
Service d’hématologie, Hôpital Saint Louis, AP-HP, Université Paris Diderot, Paris, France
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, . 2015 Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in
Rebecca Dobson
Rebecca Dobson
Department of Cardiology, Department of Obesity and Endocrinology, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
Department of Cardiology, Department of Obesity and Endocrinology, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
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Department of Cardiology, Department of Obesity and Endocrinology, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
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Daniel J Cuthbertson
Daniel J Cuthbertson
Department of Cardiology, Department of Obesity and Endocrinology, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
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Malcolm I Burgess
Malcolm I Burgess
Department of Cardiology, Department of Obesity and Endocrinology, Clinical Sciences Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
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( Pellikka et al . 1993 ), there is no current consensus on how to most accurately define and quantify carcinoid heart disease. This has led to several different echocardiographic scoring systems being developed to describe the disease, which have been used
Mouna Tabebi
Mouna Tabebi
Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden
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Peter Söderkvist
Peter Söderkvist
Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden
Clinical Genomics Linköping, Linköping University, Linköping, Sweden
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Clinical Genomics Linköping, Linköping University, Linköping, Sweden
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Oliver Gimm
Oliver Gimm
Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden
Department of Surgery, Linköping University, Linköping, Sweden
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Department of Surgery, Linköping University, Linköping, Sweden
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PPGLs are considered to be malignant and metastasize, the currently existing tools to predict which ones are insufficient. Several histopathologic scoring systems have been proposed and in 2002, Thompson developed the first pathology scoring system, PCC
Arthur S Tischler
Arthur S Tischler
Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA
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Ronald R deKrijger
Ronald R deKrijger
Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA
Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA
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Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA
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individual findings have been sufficiently reliable to allow a tumor to be confidently dismissed as benign. Attempts have therefore been made to develop multiparameter scoring systems for risk stratification. A seminal study of pheochromocytomas and
S G Creemers
S G Creemers
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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P M van Koetsveld
P M van Koetsveld
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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F J van Kemenade
F J van Kemenade
Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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T G Papathomas
T G Papathomas
Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Histopathology, King’s College Hospital, Denmark Hill, London, UK
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Department of Histopathology, King’s College Hospital, Denmark Hill, London, UK
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G J H Franssen
G J H Franssen
Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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F Dogan
F Dogan
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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E M W Eekhoff
E M W Eekhoff
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
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P van der Valk
P van der Valk
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
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W W de Herder
W W de Herder
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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J A M J L Janssen
J A M J L Janssen
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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R A Feelders
R A Feelders
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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L J Hofland
L J Hofland
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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surgery ( Lacroix 2010 ). However, the discrimination of ACCs from adrenocortical adenomas (ACAs) still remains challenging on both imaging and postoperative histopathological grounds. The current pathological scoring system (Weiss score) is limited by a
Yuet-Kin Leung
Yuet-Kin Leung
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Hung-Ming Lam
Hung-Ming Lam
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Shulin Wu
Shulin Wu
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Dan Song
Dan Song
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Linda Levin
Linda Levin
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Liang Cheng
Liang Cheng
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Chin-Lee Wu
Chin-Lee Wu
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Shuk-Mei Ho
Shuk-Mei Ho
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
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cytoplasmic signals of each ERβ isoform were examined separately. Signal intensity and percentage of signal coverage of each region were scored according to the Allred scoring system ( Allred et al . 1993 ). The intensity signal was graded from 0 to 3 (0
Noriko Kimura
Noriko Kimura
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Ryoichi Takayanagi
Ryoichi Takayanagi
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Nae Takizawa
Nae Takizawa
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Eiji Itagaki
Eiji Itagaki
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Takayuki Katabami
Takayuki Katabami
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Narihiko Kakoi
Narihiko Kakoi
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Hiromi Rakugi
Hiromi Rakugi
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Yukihiro Ikeda
Yukihiro Ikeda
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Akiyo Tanabe
Akiyo Tanabe
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Takeshi Nigawara
Takeshi Nigawara
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Sadayoshi Ito
Sadayoshi Ito
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Itaru Kimura
Itaru Kimura
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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Mitsuhide Naruse
Mitsuhide Naruse
Pathology Division, Department of Medicine and Bioregulatory Science, Department of Urology and Andrology, Third Department of Internal Medicine (Diabetes Endocrine and Metabolism), Department of Medicine, Department of Urology, Department of Geriatric Medicine and Nephrology, Division of Nephrology, Department of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, Division of Nephrology, Council Member Examination Committee of Social Insurance, Department of Endocrinology, Department of Clinical Research, National Hospital Organization, Hakodate Hospital, Postal cord 041-8512, 18-16 Kawahara, Hakodate, Hokkaido, Japan
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The Phaeochromocytoma Study Group in Japan
The Phaeochromocytoma Study Group in Japan
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confluent (comedo-type) tumour necrosis ( Zelinka et al . 2011 ), have been used in previous studies ( Kimura & Sasano 1990 , Linnoila et al . 1990 , Unger et al . 1991 ). Such features have been combined in a scoring system named the Phaeochromocytoma
G Riesco-Eizaguirre
G Riesco-Eizaguirre
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P Gutiérrez-Martínez
P Gutiérrez-Martínez
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M A García-Cabezas
M A García-Cabezas
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M Nistal
M Nistal
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P Santisteban
P Santisteban
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well-established prognostic factors can help to ascertain the most appropriate treatment and follow-up for these patients. Several prognostic scoring systems, such as the tumour node metastasis (TNM) classification ( American Joint Committee on Cancer
