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V Craig Jordan Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

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Park, but they suggested I should stay in school. My mother and I visited Mr Armishaw, the headmaster at Moseley Hall to plead my case. He did not have a chance! She promised I would comply with the law and would quickly get two further O levels and

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus MC & Erasmus MC Cancer Institute, ENETS Center of Excellence, Rotterdam, the Netherlands

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Günter Klöppel Department of Pathology, Technical University Munich, Munich, Germany

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gangrenous leg with an alcoholic extract of the pancreas with the idea to counteract the effects of adrenaline, because he believed in antagonism between adrenaline and insulin as a cause of diabetes. The treatment led to a 5-day improvement, but the patient

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Andrea Gutierrez Maria Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Christina Tatsi Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA
Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver, National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Annabel Berthon Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Ludivine Drougat Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Nikolaos Settas Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Fady Hannah-Shmouni Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Jerome Bertherat Service d’Endocrinologie, Hôpital Cochin, APHP, Institut Cochin, INSERM U1016, Université de Paris, Paris, France

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Fabio R Faucz Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA

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Constantine A Stratakis Section on Endocrinology & Genetics (SEGEN), National Institutes of Health (NIH), Bethesda, Maryland, USA
Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver, National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA

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. 2008 , Vezzosi et al. 2012 ). Mutations of the armadillo repeat-containing 5 ( ARMC5 ) gene are the main causative genetic defect of PBMAH ( Assié et al. 2013 , Faucz et al. 2014 ), although others exist too, from GNAS1 to MEN1 and GIPR

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Alberto Cascón Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Lucía Inglada-Pérez Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Iñaki Comino-Méndez Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Aguirre A de Cubas Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Rocío Letón Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Jaume Mora Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Mónica Marazuela Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Juan Carlos Galofré Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Miguel Quesada-Charneco Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Mercedes Robledo Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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novo ) p.(Arg161Gln) No 18 9 F TA PGL, PCC Fe, He, Di NE No No VHL c.482G>A ( de novo ) b p.(Arg161Gln) No 5 10, 17 M bPCC LP NE Yes (17 years/lung) No VHL c.499C>T ( de novo ) b p.(Arg167Gln) No 7 14 F bPCC LP None No PT (26 years) VHL c.499C>T ( de

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E Louiset INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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K Isvi INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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J M Gasc INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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C Duparc INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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B Cauliez INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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A Laquerrière INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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J M Kuhn INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France
INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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H Lefebvre INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France
INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France

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Immunohistological localization of 5-HT. (A) Low magnification view (HES coloration) showing the localization of the microscopic fields (empty squares) presented in B–H. L, tumor lobule; PAT, peritumorous adrenocortical tissue. (B and C) Immunohistochemical

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Raghavendra T K Poluri Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Virginie Paquette Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Éric P Allain Laboratoire de pharmacogénomique, Centre de recherche CHU de Québec – Université Laval et Faculté de Pharmacie, Université Laval, Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Camille Lafront Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Charles Joly-Beauparlant Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Cindy Weidmann Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Arnaud Droit Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Chantal Guillemette Laboratoire de pharmacogénomique, Centre de recherche CHU de Québec – Université Laval et Faculté de Pharmacie, Université Laval, Centre de recherche sur le cancer – Université Laval, Québec, Canada

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Martin Pelletier Département de microbiologie- infectiologie et d’immunologie, Faculté de médecine, Axe maladies infectieuses et immunitaires du Centre de Recherche du CHU de Québec – Université Laval et Centre de recherche ARThrite – Université Laval, Québec, Canada

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Étienne Audet-Walsh Département de médecine moléculaire, Faculté de médecine, Axe Endocrinologie – Néphrologie du Centre de recherche Centre Hospitalier Universitaire (CHU) de Québec – Université Laval, et Centre de recherche sur le cancer – Université Laval, Québec, Canada

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prostate cancer cells . International Journal of Cancer 136 536 – 546 . ( https://doi.org/10.1002/ijc.29028 ) Ma JB Bai JY Zhang HB Jia J Shi Q Yang C Wang X He D Guo P 2020 KLF5 inhibits STAT3 activity and tumor metastasis in

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D Grahame Hardie Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK

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different if he had been using cultured tumour cells! Another interesting feature of Fig. 4 is the high flux from malate to pyruvate via malic enzyme (Mal → Pyr; 10 nmol/min/mg). Along with the oxidative branch of the pentose phosphate pathway (G6P → P5P

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Paraskevi Xekouki Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Spyridon A Mastroyiannis Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Dimitrios Avgeropoulos Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Maria de la Luz Sierra Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Giampaolo Trivellin Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Evgenia A Gourgari Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Charalampos Lyssikatos Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Martha Quezado Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Nicholas Patronas Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Christina Kanaka-Gantenbein Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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George P Chrousos Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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Constantine A Stratakis Health (NIH), Laboratory of Pathology, Department of Diagnostic Radiology, Endocrine Unit, NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, Maryland, 20892, USA

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initial presentation, his height was 186.6 cm ( z -score +4.72), over the calculated mid-parental height (180.5±4.5 cm), and his weight was 78.7 kg ( z -score +2.59). He was also macrocephalic and he had several facial characteristics typical of gigantism

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Yu-Cheng Wang UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Emerick Gallego-Arteche UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Gioia Iezza UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Xiaochen Yuan UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Mary R Matli UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Su-Pin Choo UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Marlene B Zuraek UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Ravi Gogia UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Francis C Lynn UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Michael S German UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Emily K Bergsland UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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David B Donner UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Robert S Warren UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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Eric K Nakakura UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of
UCSF Helen Diller Family Comprehensive Cancer Center, Surgery, Pathology, Medicine, Hormone Research Institute, Departments of

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et al . 1998 ). At this time point, mutant embryos are viable and gut hormones are present. By routine H&E staining, we did not detect any abnormalities in the appearance of Nkx2.2 (−/−) intestine (data not shown). We first assayed for 5-HT

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Yu-cheng Wang UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Marlene B Zuraek UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Yasuhiro Kosaka UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Yasuharu Ota UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Michael S German UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Evan S Deneris UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Emily K Bergsland UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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David B Donner UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Robert S Warren UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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Eric K Nakakura UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center
UCSF Helen Diller Family Comprehensive Cancer Center, Department of Surgery, Hormone Research Institute, Department of Medicine, Department of Neurosciences, Diabetes Center

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or hormone expression To elucidate the role of FEV in intestinal endocrine cell development, we analyzed the proximal SI (duodenum) in Fev (−/−) mice at E18.5. Routine H&E staining showed no abnormalities in the appearance of Fev (−/−) SI (data

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