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INSERM UMR745, Biological and Pharmaceutical Sciences University, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
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Department of Medical Oncology, Hôpital Cochin, Assistance Publique – Hôpitaux de Paris, Paris, France
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Department of Endocrinology, Cochin Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France
Reference Center for Rare Adrenal Diseases, Reference Center for Rare Adrenal Cancer Network COMETE, Hôpital Cochin, AssistancePublique – Hôpitaux de Paris, Paris, France
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Department of Endocrinology, Cochin Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France
Reference Center for Rare Adrenal Diseases, Reference Center for Rare Adrenal Cancer Network COMETE, Hôpital Cochin, AssistancePublique – Hôpitaux de Paris, Paris, France
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Dear Editor, Adrenocortical carcinomas (ACC) are rare but aggressive tumors. Currently, the single curative approach is complete surgery. Prognosis, response to treatment and recurrence remain unpredictable, which stresses the need for new
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Dear Editor In the last decade, relevant progresses in the molecular basis of adrenocortical tumors (ACTs) were achieved and abnormalities involving growth pathway deregulation were frequently associated with malignancy. Remarkably, upregulation of
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Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Rouen, France
Clinical Investigation Centre, INSERM, CIC1404, Rouen University Hospital, Rouen, France
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Introduction Adrenocortical tumors are frequent in the general population and remain underdiagnosed. Their prevalence increases with aging and has been estimated from 1 to 8.7% in some series ( Reinhard et al. 1996 , Tabarin et al. 2008
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Department of Endocrinology, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
Department of Hormonology, AP-HP, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, AP-HP, Hôpital Cochin, Paris, France
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Introduction Benign adrenocortical lesions (tumors and hyperplasia) gather a large spectrum of diseases, among them adrenocortical adenomas (ACA), primary bilateral macronodular hyperplasia (PMAH), primary pigmented micronodular dysplasia
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INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France
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INSERM U413, Department of Endocrinology, INSERM U833, Department of Pathology, EA4310, IFRMP 23, Laboratory of Differentiation and Neuronal and Neuroendocrine Communication, University of Rouen, Mont Saint Aignan 76821, France
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including carcinomas ( Racz et al . 1992 ). In addition, two cases of adrenocortical tumors associated with elevated plasma renin concentrations have also been reported, indicating that, after its local synthesis, renin can be released in the plasma by
The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
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Center for Cancer Engineering, The Ohio State University, Columbus, Ohio, USA
Division of Surgical Oncology, The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
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, adrenal, pancreas, parathyroid, and pituitary glands. Specific examples include thyroid cancers, adrenocortical carcinoma (ACC), neuroendocrine tumors (NETs), paraganglioma, and pheochromocytoma ( Belfiore & Perks 2013 ). With incidences of several
CNRS UMR7275, Valbonne, France
NEOGENEX CNRS International Associated Laboratory, Valbonne, France
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France
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the adrenolytic agent mitotane ( Terzolo et al. 2007 ) and of combination chemotherapy in patients with progressive disease ( Fassnacht et al . 2012 ). Classically, malignancy of adrenocortical tumors (ACTs) has been assessed based on evaluation of
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2010 ). Only in rare cases, the adrenal tumor has malignant potential. Adrenocortical carcinoma (ACC) is a highly malignant tumor with 5-year-survival ranging from 16 to 38% ( Kebebew et al. 2006 , Fassnacht et al. 2013 ). The Weiss score (WS
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endogenous cortisol excess (Cushing syndrome) due to the development of multiple bilateral adrenocortical tumors ( Bouys et al. 2021 ). ARMC5 is located at chromosome 16p11.2, ubiquitously expresses and encodes a protein of 935 amino acids mostly and
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Introduction Adrenocortical carcinoma (ACC) is a rare (1:4×10 6 annual estimated incidence) and aggressive endocrine tumor with a poor prognosis, generally characterized by a limited response to radio/chemotherapy ( Allolio & Fassnacht 2006