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A M Lorincz
A M Lorincz
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S Sukumar
S Sukumar
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Obesity and breast cancer Over 40 000 women in the USA die each year of metastatic breast cancer, for which there are currently no permanent cures. In fact, about one-half of women with metastatic disease who undergo therapeutic
Nicola Normanno
Nicola Normanno
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Massimo Di Maio
Massimo Di Maio
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Ermelinda De Maio
Ermelinda De Maio
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Antonella De Luca
Antonella De Luca
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Andrea de Matteis
Andrea de Matteis
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Antonio Giordano
Antonio Giordano
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Francesco Perrone
Francesco Perrone
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Introduction It has long been established that estrogen is involved in the pathogenesis of breast carcinoma, and that it sustains the growth of breast cancer cells that express the receptor for this hormone. Indeed, approximately 70
John W Cassidy
John W Cassidy
Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK
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Ankita S Batra
Ankita S Batra
Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK
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Wendy Greenwood
Wendy Greenwood
Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK
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Alejandra Bruna
Alejandra Bruna
Department of Oncology, University of Cambridge, Cambridge, UK
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Introduction Breast cancer (herein BC) is not a single disease, but is instead a collection of diseases that have distinct histopathological features and genetic and genomic variability linked to diverse prognostic outcomes. Recent research
V Craig Jordan
V Craig Jordan
Departments of Breast Medical Oncology and Molecular and Cellular Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA
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) and Little Brown and Co. Boston (USA)) The fact that estrogen is implicated as the ‘fuel for the fire’ of breast cancer is ingrained in women's psyche. The Food and Drug Administration (FDA) has institutionalized the principle, by warning of the
Zhi-yuan Pang
Zhi-yuan Pang
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Yun-tao Wei
Yun-tao Wei
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Mu-yan Shang
Mu-yan Shang
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Shuang Li
Shuang Li
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Yang Li
Yang Li
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Quan-xiu Jin
Quan-xiu Jin
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Zhi-xuan Liao
Zhi-xuan Liao
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Ming-ke Cui
Ming-ke Cui
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Xiao-yan Liu
Xiao-yan Liu
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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Qiang Zhang
Qiang Zhang
Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
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2010 and December 2018. Tissues were obtained from mastectomy at Department of Breast Surgery in Liaoning Cancer Hospital & Institute. BCa samples were subdivided into ‘Responding’ (complete or partial response to letrozole, n = 60) and ‘Non
Andrew M K Law
Andrew M K Law
Tumour Development Group, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
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Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
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Elgene Lim
Elgene Lim
Connie Johnson Breast Cancer Research Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia
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St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia
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Christopher J Ormandy
Christopher J Ormandy
Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia
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St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia
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David Gallego-Ortega
David Gallego-Ortega
Tumour Development Group, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia
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St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia
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-like receptor agonists and more recently, checkpoint inhibitor blockade are some of the therapeutic approaches with proven success in several types of cancer. The low immunogenicity and intense immunosuppressive environment of breast tumours limit the benefit
Liyan Zhou
Liyan Zhou
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Guiying Bai
Guiying Bai
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yue Song
Yue Song
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xiaohui Liu
Xiaohui Liu
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Xiaoqing Li
Xiaoqing Li
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yilin Deng
Yilin Deng
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yiran Si
Yiran Si
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Yehui Shi
Yehui Shi
Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Hongli Li
Hongli Li
Department of Phase I Clinical Trial, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
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Introduction Breast cancer is the most prevalent malignant tumor in women worldwide, significantly affecting the quality of life and threatening the health of women ( Giaquinto et al. 2022 ). Multiple meta-analyses have shown that the risk
Hatem A Azim Jr
Hatem A Azim Jr
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Sylvain Brohée
Sylvain Brohée
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Fedro A Peccatori
Fedro A Peccatori
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Christine Desmedt
Christine Desmedt
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Sherene Loi
Sherene Loi
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Diether Lambrechts
Diether Lambrechts
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Patrizia Dell'Orto
Patrizia Dell'Orto
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Samira Majjaj
Samira Majjaj
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Vinu Jose
Vinu Jose
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Nicole Rotmensz
Nicole Rotmensz
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Michail Ignatiadis
Michail Ignatiadis
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Giancarlo Pruneri
Giancarlo Pruneri
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Martine Piccart
Martine Piccart
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Giuseppe Viale
Giuseppe Viale
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Christos Sotiriou
Christos Sotiriou
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Department of Medicine Institut Jules Bordet, BrEAST Data Centre, Université Libre de Bruxelles (ULB), Boulevard de Waterloo, 121, 1000 Brussels, Belgium
Breast Cancer Translational Research Laboratory (BCTL) J. C. Heuson Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
Fertility and Procreation Unit Department of Gynecologic Oncology, European Institute of Oncology, Milan, Italy
Translational Breast Cancer Genomic Lab Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Victoria, Australia
Vesalius Research Centre VIB, Leuven, Belgium
Laboratory of Translational Genetics Department of Oncology, University of Leuven, Leuven, Belgium
Department of Pathology Division of Epidemiology and Biostatistics European Institute of Oncology, Milan, Italy
Department of Medicine Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Introduction Breast cancer arising in young women exhibits distinct biological features and has been shown to pursue an aggressive clinical behavior ( Cancello et al . 2010 , Azim et al . 2012 a , Collins et al . 2012 , Narod 2012 ). Among the
B Arun
B Arun
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. barun@mdanderson.org
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G N Hortobagyi
G N Hortobagyi
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. barun@mdanderson.org
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Over the past years there have been significant advances in breast cancer treatment and early detection. For the first time, a decrease in cancer mortality has been observed. Recently, much progress has been made in the understanding of carcinogenesis partly due to available new technologies to detect early molecular changes in the tissue. The knowledge of breast cancer carcinogenesis has provided possible opportunities to prevent breast cancer. Currently, several clinical breast cancer prevention trials are ongoing. This paper reviews issues related to breast cancer chemoprevention including identification of high risk cohorts, endpoint biomarkers, current and new chemopreventive agents as well as models to evaluate these agents.
Philipp Y Maximov
Philipp Y Maximov
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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Balkees Abderrahman
Balkees Abderrahman
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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Ramona F Curpan
Ramona F Curpan
Institute of Chemistry, Romanian Academy, Timisoara, Romania
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Yousef M Hawsawi
Yousef M Hawsawi
Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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Ping Fan
Ping Fan
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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V Craig Jordan
V Craig Jordan
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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Introduction Despite advances in understanding the molecular biology of prostate and breast cancers, they are still the most frequently diagnosed cancers in men and women, in the United States. There is no completely effective preventative for
