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Yasuhiko Nagano
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Do Ha Kim
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Li Zhang
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Stanley R Hamilton
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Asif Rashid
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. Wang GG , Yao JC, Worah S, White JA, Luna R, Wu TT, Hamilton SR & Rashid A 2005 Comparison of genetic alterations in neuroendocrine tumors: frequent loss of chromosome 18 in ileal carcinoid tumors. Modern Pathology 18 1079 –1087

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Sock Hoai Chan Division of Medical Oncology, Cancer Genetics Service, National Cancer Centre Singapore, Singapore

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Joanne Ngeow Division of Medical Oncology, Cancer Genetics Service, National Cancer Centre Singapore, Singapore
Oncology Academic Clinical Program, Duke-NUS Medical School Singapore, Singapore

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Introduction Genomic instability is a hallmark of human cancers ( Negrini et al. 2010 ). It refers to the increased frequency of accruing genetic alterations, ranging from single nucleotide mutations to whole chromosome changes such as

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Jie Cai School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Lin Li School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Lei Ye School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Xiaohua Jiang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Liyun Shen School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Zhibo Gao School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Weiyuan Fang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Fengjiao Huang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Tingwei Su School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Yulin Zhou School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Weiqing Wang School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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Guang Ning School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China
School of Medicine, BGI-Shenzhen, Laboratory for Endocrine and Metabolic Diseases of Institute of Health Science, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, #197 Ruijin 2nd Road, Shanghai 200025 People's Republic of China

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proliferation or phosphorylation of RET receptor was observed between the transfected cell lines ( Supplementary Fig. 3 , see section on supplementary data given at the end of this article). Discussion In this study we profiled genetic alterations in matched

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Adam Stenman Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Samuel Backman Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Klara Johansson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Johan O Paulsson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Peter Stålberg Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden

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thyroid nodules ( Francis et al. 2015 ). From a genetic standpoint, gene fusion events are significantly overrepresented in pediatric thyroid cancer as opposed to adult tumors, whereas the latter entity exhibits more frequent mutational events compared

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M Tenhagen Department of Pathology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

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P J van Diest Department of Pathology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

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I A Ivanova Department of Pathology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

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E van der Wall Department of Pathology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

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P van der Groep Department of Pathology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Department of Pathology, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

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prognosis of breast cancer patients, but still 458 503 women died from the disease in 2008 ( Ferlay et al . 2008 ). Therefore, the development of new therapies is focused on the specific genetic abnormalities in individual cancers, resulting in more

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Valdemar Máximo Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Jorge Lima Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Hugo Prazeres Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Paula Soares Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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Manuel Sobrinho-Simões Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal
Institute of Pathology and Immunology of the University of Porto (IPATIMUP), Department of Pathology, Portugese Institute of Oncology, Department of Pathology, Rua Roberto Frias s/n, 4200-465 Porto, Portugal

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divided for the sake of simplicity into two categories: genetic alterations that are linked with the three main histotypes of follicular cell-derived thyroid carcinomas (FTC, PTC, and PDTC) and the genetic alterations that are linked to the acquisition of

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Tiago Bordeira Gaspar i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
ICBAS – Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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José Manuel Lopes i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Department of Pathology, Centro Hospitalar e Universitário de São João, Porto, Portugal

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Paula Soares i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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João Vinagre i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Ipatimup – Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
FMUP – Faculdade de Medicina da Universidade do Porto, Porto, Portugal

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effect could be prevented by using sunitinib, a Vegf-signaling inhibitor. Novel PanNEN mouse models The last decade was prolific in identifying novel genetic alterations influencing PanNEN genesis and/or progression. So far, the most

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M Lacroix Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 boulevard de Waterloo, B-1000 Bruxelles, Brussels, Belgium

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R-A Toillon Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 boulevard de Waterloo, B-1000 Bruxelles, Brussels, Belgium

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G Leclercq Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Université Libre de Bruxelles, 127 boulevard de Waterloo, B-1000 Bruxelles, Brussels, Belgium

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are expected to often be significantly different from those observed in BCCs in situ . In fact, a number of recent data—of pathological, molecular and genetic nature—have revealed that despite increasing genetic alteration, the ‘portrait’ of

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Esra Karslioglu French Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Linwah Yip Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Sally E Carty Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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(Bethesda IV; FN), and Suspicious for Malignancy (Bethesda V; SFM). Molecular testing (MT) to examine somatic genetic alterations has become an important adjunct in the diagnosis and treatment of many cancers and today is primarily utilized in thyroid

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WenQi Yuan Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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WeiQinq Wang Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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Bin Cui Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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TingWei Su Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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Yan Ge Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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Lei Jiang Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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WeiWei Zhou Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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Guang Ning Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China

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tumors in a total of 76 genes spanning almost all chromosome arms that were included in the P005 and P006 probe mixes. Colors used: green, gain; red, loss; and white, no genetic alteration. ERBB-2 is emphasized with purple color. The deletion or

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