To determine the alteration of gene expression in mouse Men1 insulinomas at different stages during tumour initiation and progression, mRNAs were isolated from hand-picked pancreatic islets of two Men1 F/F mice, two Men1 β-cell-specific mutant
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S Fontanière, J Tost, A Wierinckx, J Lachuer, J Lu, N Hussein, F Busato, I Gut, Z-Q Wang, and C-X Zhang
Alessia Di Florio, Gabriele Capurso, Massimo Milione, Francesco Panzuto, Raffaele Geremia, Gianfranco Delle Fave, and Claudio Sette
Introduction Pancreatic endocrine tumours (PETs) are rare neoplasms arising from pancreatic islet cells. PETs are classified as ‘functioning’ (F) or ‘non-functioning’ (NF) depending on the presence or absence of a syndrome due to
Z Hamze, C Vercherat, A Bernigaud-Lacheretz, W Bazzi, R Bonnavion, J Lu, A Calender, C Pouponnot, P Bertolino, C Roche, R Stein, J Y Scoazec, C X Zhang, and M Cordier-Bussat
were classified as neuroendocrine neoplasms G1 and the other five were neuroendocrine neoplasms G2. One tumour was associated with MEN1 syndrome, while the others were sporadic. Three patients had distant metastases. Murine tissues Pancreatic islets and
Mieke E R Henfling, Aurel A Perren, Anja M Schmitt, Christiane M Saddig, Achim A Starke, Robert G Riedl, Yvonne M H Versleijen-Jonkers, Diana M Sprij-Mooij, Frans C S Ramaekers, Leo J Hofland, and Ernst-Jan M Speel
membranous staining. In normal human pancreas a low number of acinar cells showed a weakly positive membranous staining, whereas the islet cells were negative for EGFR ( Table 2 and Fig. 1A , B and C ). Figure 1 Representative examples of
Sebastian Krug, Benjamin Kühnemuth, Heidi Griesmann, Albrecht Neesse, Leonie Mühlberg, Michael Boch, Juliane Kortenhaus, Volker Fendrich, Dominik Wiese, Bence Sipos, Juliane Friemel, Thomas M Gress, and Patrick Michl
transgenic mouse model of islet cell neoplasms . Annals of Surgery 254 818 – 823 . (discussion 823) ( doi:10.1097/SLA.0b013e318236bc0f ). Ghayouri M Boulware D Nasir A Strosberg J Kvols L Coppola D 2010 Activation of the serine
Thorvardur R Halfdanarson, Joseph Rubin, Michael B Farnell, Clive S Grant, and Gloria M Petersen
). Korpássy (1939) found four cases (0.8%) of macroscopic islet cell adenomas in 500 autopsies in 1938. Twenty-four cases (0.3%) of ‘benign islet cell neoplasms’ were observed in a series of 9158 consecutive autopsies reported by Frantz (1959) . Warren et
Claudio Ricci, Stefano Partelli, Carlo Ingaldi, Valentina Andreasi, Davide Campana, Francesca Muffatti, Laura Alberici, Cecilia Giorgi, Riccardo Casadei, and Massimo Falconi
OR pancreatic neuroendocrine neoplasm OR pancreatic neuroendocrine neoplasms OR Adenomas, Islet Cell OR Islet Cell Adenoma OR Islet Cell Adenomas OR Islet Cell Tumor OR Islet Cell Tumors OR Tumor, Islet Cell OR Tumors, Islet Cell OR Island Cell Tumor
Jan Willem B de Groot, Bart Rikhof, Jaap van Doorn, Henk J G Bilo, Maarten A Alleman, Aafke H Honkoop, and Winette T A van der Graaf
), secretion of insulin-like growth factor (IGF)-I ( Nauck et al . 2007 ) and tumours that secrete partially processed precursors of IGF-II (‘big’-IGF-II; Service 1995 , Marks & Teale 1998 ). The latter condition is also known as non-islet cell tumour
Roman Vangoitsenhoven, Chantal Mathieu, and Bart Van der Schueren
developed pancreatitis, nor any treatment-related effects concerning islet cell hyperplasia or benign adenomas after 2 years of treatment with liraglutide. There were no histological signs of pancreatitis in nonhuman primates after 52 weeks of treatment
Günter Klöppel
includes the tumours that generate steroid hormones. The tumours of the first group are called neuroendocrine neoplasms (NENs) because of the marker proteins that they share with the neural cell system. These markers are synaptophysin and neuron
