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Krzysztof Fujarewicz
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Michał Jarząb
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Markus Eszlinger
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Knut Krohn
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Ralf Paschke
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Małgorzata Oczko-Wojciechowska
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Małgorzata Wiench
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Aleksandra Kukulska
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Barbara Jarząb
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Andrzej Swierniak
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). Bootstrap-based multi-gene classification of PTC microarray data Selection of genes is an important goal of microarray studies contributing to broader understanding of the cancer transcriptome as well as yielding novel molecular cancer markers

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0048
Volume/Issue:
Volume 14: Issue 3
Free access
Arthur S Tischler Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA

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Ronald R deKrijger Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA
Department of Pathology and Laboratory Medicine, Department of Pathology, Department of Pathology, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA

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& Wimalawansa 2015 ). It is now recognized that metastatic potential and patient outcomes vary with genotype of hereditary pheochromocytoma/paraganglioma, and pathologists have begun to search for both morphological and immunohistochemical markers that would

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0261
Volume/Issue:
Volume 22: Issue 4
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Ta-Chun Yuan
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Suresh Veeramani
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Ming-Fong Lin
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specimens are positively stained with antibodies (Abs) against luminal secretory cell-associated cytokeratins; while they are negative for staining with Abs against basal cell markers, including high molecular weight cytokeratin and p63 ( Wojno & Epstein

Article Type:
Review Article
DOI:
https://doi.org/10.1677/ERC-07-0061
Volume/Issue:
Volume 14: Issue 3
Free access
Annunziata Di Domenico Institute of Pathology, University of Bern, Bern, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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Tabea Wiedmer Institute of Pathology, University of Bern, Bern, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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Ilaria Marinoni Institute of Pathology, University of Bern, Bern, Switzerland

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Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

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markers, such as chromogranin A and synaptophysin, which are used in the histopathological diagnosis. NET are classified as functional or non-functional, depending on syndromes due to inadequate hormone secretion. While functional NET can induce dramatic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0012
Volume/Issue:
Volume 24: Issue 9
Free access
Bruno Ragazzon Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France

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Guillaume Assié Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France

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Jérôme Bertherat Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
Institut Cochin, Inserm, Department of Endocrinology, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France

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et al . 1993 , Rainier et al . 1993 , Gicquel et al . 1997 ). Interestingly, it has been previously demonstrated that IGF2 expression could be used as a molecular marker for the diagnosis of ACC ( Gicquel et al . 2001 ). The IGF signaling pathway

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0220
Volume/Issue:
Volume 18: Issue 2
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Tanner Freeman Department of Pathology, UPMC, Pittsburgh, Pennsylvania, USA

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Charit Taneja Division of Endocrinology and Metabolism, UPMC, Pittsburgh, Pennsylvania, USA

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N Paul Ohori Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Abigail I Wald Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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John Skaugen Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Linwah Yip Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Seungwon Kim Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Robert L Ferris Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
UPMC Hillman Cancer Center, Department of Oncology, Pittsburgh, Pennsylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Somak Roy Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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2018 ). This association raises the possibility of utilizing molecular markers to detect RCC metastatic to distant sites. ThyroSeq ® version 3 (v3), a targeted next-generation sequencing (NGS) test used for thyroid nodules with indeterminate cytology

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0195
Volume/Issue:
Volume 29: Issue 12
Restricted access
Thais Biude Mendes Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Bruno Heidi Nozima Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Alexandre Budu Enzymology Laboratory, Department of Biophysics, Universidade Federal de São Paulo, São Paulo, Brazil

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Rodrigo Barbosa de Souza Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Marcia Helena Braga Catroxo Laboratory of Electron Microscopy, Center for Research and Development of Animal Health, Instituto Biológico, São Paulo, Brazil

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Rosana Delcelo Department of Pathology, Universidade Federal de São Paulo, São Paulo, Brazil

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Marcos Leoni Gazarini Cell Signaling Laboratory in Plasmodium, Department of Biosciences, Universidade Federal de São Paulo, Santos, São Paulo, Brazil

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Janete Maria Cerutti Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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). Indeterminate nodules often undergo surgical excision for a definitive diagnosis. For better classification of a disease state and improved clinical decision-making, preoperative molecular markers have been considered. We have previously identified four

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0181
Volume/Issue:
Volume 23: Issue 9
Free access
Esther Korpershoek Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Room Ae304, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Claudia K Stobbe Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Room Ae304, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Francien H van Nederveen Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Room Ae304, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Ronald R de Krijger Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Room Ae304, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Winand N M Dinjens Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Room Ae304, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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patient 19 did not show LOH with four and six informative markers respectively. This is probably due to the absence of genomic alterations at these loci, but to confirm this more markers should be tested. Molecular heterogeneity could also be due to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0072
Volume/Issue:
Volume 17: Issue 3
Free access
Martin K Bakht Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Iulian Derecichei Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Yinan Li Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Rosa-Maria Ferraiuolo Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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Mark Dunning Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK

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So Won Oh Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

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Abdulkadir Hussein Department of Mathematics and Statistics, University of Windsor, Windsor, Ontario, Canada

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Hyewon Youn Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Tumor Microenvironment Global Core Research Center, Seoul National University, Seoul, Korea
Cancer Imaging Center, Seoul National University Hospital, Seoul, Korea

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Keith F Stringer Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada
Department of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

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Chang Wook Jeong Department of Urology, Seoul National University College of Medicine, Seoul, Korea

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Gi Jeong Cheon Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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Cheol Kwak Department of Urology, Seoul National University College of Medicine, Seoul, Korea

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Keon Wook Kang Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

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Alastair D Lamb Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

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Yuzhuo Wang Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, British Columbia, Canada

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Xuesen Dong Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Lisa A Porter Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada

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transmembrane protein prostate-specific membrane antigen (PSMA) is an appealing target for molecular imaging and therapy of AdPC since it is overexpressed in a majority of AdPC tumors and metastatic lesions ( Rai et al . 2016 ). Targeting PSMA is feasible by a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0226
Volume/Issue:
Volume 26: Issue 2
Free access
Catherine Ory
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Nicolas Ugolin
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Céline Levalois
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Ludovic Lacroix CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Bernard Caillou CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Jean-Michel Bidart CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Martin Schlumberger CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Ibrahima Diallo CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Florent de Vathaire CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Paul Hofman CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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José Santini CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Bernard Malfoy CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Sylvie Chevillard
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tumor. Molecular differences between sporadic and radiation-induced thyroid tumors were sought using microarray transcriptome analysis. The first study, including sporadic and post-Chernobyl PTC, did not show any specific radiation-induced gene

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0205
Volume/Issue:
Volume 18: Issue 1
Open access
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