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Guido Rindi Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Università Cattolica del Sacro Cuore, Rome, Italy
ENETS Center of Excellence, Neuroendocrine Tumour (NET) Center, Rome, Italy

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Frediano Inzani Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
ENETS Center of Excellence, Neuroendocrine Tumour (NET) Center, Rome, Italy

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the poorly differentiated lesion, defined as neuroendocrine carcinoma (NEC). (A, B and C) NET G1 displays a trabecular/insular structure, in absence of necrosis, and is composed of epithelial cells with abundant cytoplasm, low degree of atypia, low, if

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0036
Volume/Issue:
Volume 27: Issue 6
Free access
Jennifer R Eads Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Pennsylvania, USA

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Thorvardur R Halfdanarson Division of Medical Oncology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA

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Tim Asmis Division of Medical Oncology, University of Ottawa, Ottawa, Ontario, Canada

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Andrew M Bellizzi Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Emily K Bergsland Department of Medicine, University of California, San Francisco, California, USA

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Arvind Dasari Division of Gastrointestinal Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Ghassan El-Haddad Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Michael Frumovitz Division of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Joshua Meyer Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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Erik Mittra Division of Molecular Imaging and Therapy, Oregon Health & Science University, Portland, Oregon, USA

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Sten Myrehaug Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Eric Nakakura Department of Surgery, University of California, San Francisco, California, USA

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Nitya Raj Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Heloisa P Soares Division of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Salt Lake City, Utah, USA

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Brian Untch Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Namrata Vijayvergia Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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Jennifer A Chan Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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-differentiated high-grade neuroendocrine tumors (G3 NET) and poorly differentiated high-grade neuroendocrine carcinomas (NECs). Most available literature does not account for this subcategorization and as a result, much of the management of high-grade NENs is based on

Article Type:
Other
DOI:
https://doi.org/10.1530/ERC-22-0206
Volume/Issue:
Volume 30: Issue 8
Open access
Maria Chiara Zatelli Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Elia Guadagno Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

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Erika Messina Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

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Fabio Lo Calzo Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Antongiulio Faggiano Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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NIKE Group
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considers neuroendocrine carcinomas (NECs) as a single category on the basis of a Ki-67 labeling index (LI) >20% ( Rindi et al. 2010 ). It has recently become apparent that the definition of NEC by the 2010 WHO classification includes a spectrum of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0507
Volume/Issue:
Volume 25: Issue 6
Free access
Günter Klöppel Department of Pathology, Technical University of München, Ismaninger Strasse 22, 81675 München, Germany

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neuroendocrine neoplasms with previous WHO classifications WHO 1980 WHO 2000 WHO 2010 I. Carcinoid 1. Well-differentiated endocrine tumour (WDET) a 1. Neuroendocrine tumour (NET) G1 (carcinoid) G2 a 2. Well-differentiated endocrine carcinoma (WDEC) a 3. Poorly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0013
Volume/Issue:
Volume 18: Issue S1
Free access
Lisa D Berman-Booty Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Karen E Knudsen Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Kimmel Cancer Center, Departments of Urology, Radiation Oncology, Thomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Introduction Prostate cancer is the second most common cancer in men worldwide ( Ferlay et al . 2010 ). With >90% of prostate cancers initially diagnosed as acinar adenocarcinomas ( Fine 2012 , Humphrey 2012 ), neuroendocrine carcinomas of the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0393
Volume/Issue:
Volume 22: Issue 1
Free access
C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden

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Ozgur Mete Department of Pathology, University Health Network, Toronto, ON, Canada
Endocrine Oncology Site, Princess Margaret Cancer Centre, Toronto, ON, Canada
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

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Zubair W Baloch Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

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. Frontiers in Endocrinology 9 555. ( https://doi.org/10.3389/fendo.2018.00555 ) Asa SL Mete O 2022 Medullary thyroid carcinoma in the IARC/WHO neuroendocrine schema . Endocrine Pathology 33 346 – 347 . ( https://doi.org/10.1007/s12022-022-09728-y

Article Type:
Review Article
Collections:
Mini Reviews in Endocrine Related Cancer
DOI:
https://doi.org/10.1530/ERC-22-0293
Volume/Issue:
Volume 30: Issue 2
Free access
A Mohamed Division of Hematology and Medical Oncology, UH Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA

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M Trybula Division of Hematology and Medical Oncology, UH Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA

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S L Asa Department of Medicine, UH Seidman Cancer Center Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA

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T R Halfdanarson Division of Medical Oncology, Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota, USA

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M B Sonbol Division of Hematology and Medical Oncology, Mayo Clinic Cancer Center, Phoenix, Arizona, USA

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classification, delineating G3-NETs as a distinct category from the poorly differentiated neuroendocrine carcinoma (NEC) ( Table 1 ) ( Velayoudom-Cephise et al. 2013 , Heetfeld et al. 2015 , Nagtegaal et al. 2020 , Elvebakken et al. 2021 , Luecke et

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-24-0025
Volume/Issue:
Volume 31: Issue 10
Restricted access
Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Germano Gaudenzi Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Luisa Circelli Department of Experimental Oncology, Laboratory of Molecular Biology and Viral Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, ‘Fondazione Pascale’ – IRCCS, Naples, Italy

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Marco F Manzoni Department of Endocrinology and Internal Medicine, Endocrine Tumors Unit, San Raffaele Hospital Vita-Salute San Raffaele University, Milan, Italy

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Andrea Bassi Department of Physics, Politecnico di Milano, Milan, Italy

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Niccolò Fioritti Department of Biosciences, University of Milan, Milan, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Section of Endocrinology, ‘Federico II’ University of Naples, Naples, Italy

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on behalf of NIKE Group Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy

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Introduction Medullary thyroid carcinoma (MTC) is a neuroendocrine tumour originating from parafollicular C cells. At the end of 60s, after the discovery that MTC represents a unique thyroid cancer, it was recognised that the tumour occurred

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0399
Volume/Issue:
Volume 24: Issue 1
Free access
Giulia Vocino Trucco Pathology Unit, SS. Annunziata Hospital, Savigliano, Italy

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Marco Volante Department of Oncology, University of Turin, Orbassano, Turin, Italy

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recognized based on the morphology and grade of differentiation: neuroendocrine tumors (NETs, also termed as carcinoid tumors in the thoracic location) and neuroendocrine carcinomas (NECs). In this binary framework, NETs correspond to well

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-24-0004
Volume/Issue:
Volume 31: Issue 8
Restricted access
A Perren
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S Schmid
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T Locher
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P Saremaslani
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C Bonvin
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P U Heitz
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P Komminoth
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et al. 1998 ), gastrointestinal neuroendocrine tumors (GI-NETs) ( Zhao et al. 2000 ), bronchial neuroendocrine tumors (B-NETs) ( Zhao et al. 2000 ) and PGLs ( Edstrom et al. 2000 ) and 5% of papillary thyroid carcinomas (PTC) ( Singh et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00841
Volume/Issue:
Volume 11: Issue 4
Free access