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Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK
NHS Nightingale Hospital London, London, UK

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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Introduction Neuroendocrine neoplasms (NEN) represent a heterogeneous class of tumours that arise from nigh ubiquitously dispersed neuroendocrine cells, which may be stratified into clinically meaningful sub-groups on the basis of their

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0074
Volume/Issue:
Volume 27: Issue 9
Free access
Aura D Herrera-Martínez Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Leo J Hofland Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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María A Gálvez Moreno Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Justo P Castaño Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Wouter W de Herder Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Richard A Feelders Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Introduction Neuroendocrine neoplasms (NENs) represent a heterogeneous group of rare neoplasms, which originate from enterochromaffin cells that are located throughout the whole body. NENs located in the gastrointestinal tract and pancreas are

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0354
Volume/Issue:
Volume 26: Issue 3
Free access
Maria Chiara Zatelli Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Elia Guadagno Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

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Erika Messina Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

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Fabio Lo Calzo Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Antongiulio Faggiano Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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NIKE Group
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Introduction Neuroendocrine neoplasms (NENs) are well known to display a wide heterogeneity as concerns histopathology, clinical presentation, treatment and prognosis. Despite their rarity, NENs have drawn a lot of attention due to the newly

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0507
Volume/Issue:
Volume 25: Issue 6
Free access
Corinne Gérard Aix Marseille Univ, INSERM, MMG (U1251), Marseille Medical Genetics, Marseille, France

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Marie Lagarde Aix Marseille Univ, INSERM, MMG (U1251), Marseille Medical Genetics, Marseille, France

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Flora Poizat Medical Oncology Department, Paoli-Calmettes Institute CoE-ENETS, Marseille, France

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Sandrine Oziel-Taieb Medical Oncology Department, Paoli-Calmettes Institute CoE-ENETS, Marseille, France

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Vincent Garcia Molecular Biology Laboratory, Hospital La Conception, AP-HM, Marseille, France

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Catherine Roche Molecular Biology Laboratory, Hospital La Conception, AP-HM, Marseille, France

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Patricia Niccoli Medical Oncology Department, Paoli-Calmettes Institute CoE-ENETS, Marseille, France

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Anne Barlier Aix Marseille Univ, INSERM, MMG (U1251), Marseille Medical Genetics, Marseille, France
Molecular Biology Laboratory, Hospital La Conception, AP-HM, Marseille, France

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David Romano Aix Marseille Univ, INSERM, MMG (U1251), Marseille Medical Genetics, Marseille, France

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Introduction Neuroendocrine neoplasms (NENs) (comprising well-differentiated NENs ((G1 to G3) and poorly differentiated NECs ( Inzani et al. 2018 )) are a heterogeneous group of malignancies with various clinical presentations and evolution

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0142
Volume/Issue:
Volume 28: Issue 1
Restricted access
Jennifer R Eads Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Pennsylvania, USA

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Thorvardur R Halfdanarson Division of Medical Oncology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA

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Tim Asmis Division of Medical Oncology, University of Ottawa, Ottawa, Ontario, Canada

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Andrew M Bellizzi Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Emily K Bergsland Department of Medicine, University of California, San Francisco, California, USA

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Arvind Dasari Division of Gastrointestinal Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Ghassan El-Haddad Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Michael Frumovitz Division of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

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Joshua Meyer Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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Erik Mittra Division of Molecular Imaging and Therapy, Oregon Health & Science University, Portland, Oregon, USA

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Sten Myrehaug Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Eric Nakakura Department of Surgery, University of California, San Francisco, California, USA

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Nitya Raj Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Heloisa P Soares Division of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Salt Lake City, Utah, USA

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Brian Untch Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Namrata Vijayvergia Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

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Jennifer A Chan Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Introduction High-grade neuroendocrine neoplasms (NENs) constitute a rare disease entity and account for approximately 10% of all NENs. Given their rarity, there is a paucity of prospective data to guide the optimal diagnosis and management of

Article Type:
Other
DOI:
https://doi.org/10.1530/ERC-22-0206
Volume/Issue:
Volume 30: Issue 8
Open access
Atsuko Kasajima Department of Pathology, Technical University Munich, Munich, Germany
Member of the German Cancer Consortium (DKTK), Germany

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Günter Klöppel Department of Pathology, Technical University Munich, Munich, Germany

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Introduction Neuroendocrine neoplasms (NENs) arise from various anatomical sites in the body but share basic features. NENs consist of two main families, well-differentiated NENs, also called neuroendocrine tumors (NETs) or carcinoids, and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0122
Volume/Issue:
Volume 27: Issue 11
Free access
Thomas Yang Sun Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Lan Zhao Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Paul Van Hummelen Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Brock Martin Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

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Kathleen Hornbacker Clinical Trials Office, Stanford University, Stanford, California, USA

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HoJoon Lee Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

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Li C Xia Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Division of Biostatistics, Department of Epidemiology and Public Health, Albert Einstein College of Medicine, Bronx, New York, USA

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Sukhmani K Padda Cedars-Sinai Medical Center, Department of Medical Oncology, Los Angeles, California, USA

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Hanlee P Ji Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Stanford Genome Technology Center, Stanford, California, USA

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Pamela Kunz Yale School of Medicine, Smilow Cancer Hospital, Yale Cancer Center, New Haven, Connecticut, USA

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Introduction Neuroendocrine neoplasms (NENs) commonly originate from the gastroenteropancreatic (GEP) organs and the lungs but can also arise from most other organs in the body, including the genitourinary tract, head and neck, the gynecologic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0015
Volume/Issue:
Volume 29: Issue 12
Restricted access
Maria Chiara Zatelli Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Erika Maria Grossrubatscher Endocrine Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy

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Elia Guadagno Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

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Concetta Sciammarella IOS & COLEMAN Srl, Naples, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura Dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy

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Annamaria Colao IOS & COLEMAN Srl, Naples, Italy

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Introduction Neuroendocrine neoplasms (NENs) are heterogeneous tumors with widely different behavior and prognosis, that to date had been related mainly to the grade of neuroendocrine differentiation as well as the proliferative attitude of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0091
Volume/Issue:
Volume 24: Issue 6
Free access
Federica Grillo Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genova, Italy
Ospedale Policlinico San Martino IRCCS, Genova, Italy

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Tullio Florio Pharmacology Unit, Department of Internal Medicine (DIMI), University of Genova, Genova, Italy

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Francesco Ferraù Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy

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Elda Kara Unit of Endocrinology, Metabolism, Diabetology and Nutrition, Azienda Sanitaria Universitaria Integrata di Udine, Ospedale Santa Maria della Misericordia, Udine, Italy

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Giuseppe Fanciulli Neuroendocrine Tumours Unit, Department of Clinical and Experimental Medicine, University of Sassari – AOU Sassari, Sassari, Italy

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Antongiulio Faggiano Department of Clinical Medicine and Surgery, University ‘Federico II’, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, University ‘Federico II’, Naples, Italy

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NIKE Group
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Introduction Neuroendocrine neoplasms (NENs) are a heterogeneous family of neoplasms originating from neuroendocrine cells dispersed in different organs, most frequently in the digestive system and in the lungs. The last few decades have

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0531
Volume/Issue:
Volume 25: Issue 9
Free access
Wiebke Werner Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Katharina Detjen Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Alix Bruneau Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Isabella Lurje Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Natalie Nestel Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Henning Jann Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Frank Tacke Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Bertram Wiedenmann Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Christoph Roderburg Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine, University Düsseldorf, Düsseldorf, Germany

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Linda Hammerich Department of Hepatology and Gastroenterology, Charité Universitaetsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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Introduction Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) account for approximately two-thirds of all neuroendocrine malignancies ( Kaliszewski et al. 2022 ). The current World Health Organization (WHO) classification system

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0357
Volume/Issue:
Volume 30: Issue 7
Restricted access