Search Results

You are looking at 11 - 20 of 187 items for :

  • phaeochromocytoma x
  • Refine by access: All content x
Clear All
V Häyry Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

Search for other papers by V Häyry in
Google Scholar
PubMed
Close
,
K Salmenkivi Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

Search for other papers by K Salmenkivi in
Google Scholar
PubMed
Close
,
J Arola Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

Search for other papers by J Arola in
Google Scholar
PubMed
Close
,
P Heikkilä Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

Search for other papers by P Heikkilä in
Google Scholar
PubMed
Close
,
C Haglund Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

Search for other papers by C Haglund in
Google Scholar
PubMed
Close
, and
H Sariola Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland
Institute of Biomedicine, Departments of Pathology, Otorhinolaryngology, Developmental Biology, University of Helsinki, Biomedicum, Haartmaninkatu 8, PL 63, Helsinki 00014 HY, Finland

Search for other papers by H Sariola in
Google Scholar
PubMed
Close

Introduction Phaeochromocytoma is a rare tumour of the adrenal medulla. We lack exact incidence figures in Finland, but in Sweden, the incidence is 2.1 per million ( Stenstrom & Svardsudd 1986 ). It usually arises from adrenergic cells in the

Free access
Graeme Eisenhofer Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany
Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Graeme Eisenhofer in
Google Scholar
PubMed
Close
,
Karel Pacak Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Karel Pacak in
Google Scholar
PubMed
Close
,
Thanh-Truc Huynh Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Thanh-Truc Huynh in
Google Scholar
PubMed
Close
,
Nan Qin Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Nan Qin in
Google Scholar
PubMed
Close
,
Gennady Bratslavsky Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Gennady Bratslavsky in
Google Scholar
PubMed
Close
,
W Marston Linehan Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by W Marston Linehan in
Google Scholar
PubMed
Close
,
Massimo Mannelli Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Massimo Mannelli in
Google Scholar
PubMed
Close
,
Peter Friberg Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Peter Friberg in
Google Scholar
PubMed
Close
,
Stefan K Grebe Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Stefan K Grebe in
Google Scholar
PubMed
Close
,
Henri J Timmers Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Henri J Timmers in
Google Scholar
PubMed
Close
,
Stefan R Bornstein Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Stefan R Bornstein in
Google Scholar
PubMed
Close
, and
Jacques W M Lenders Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany
Institute of Clinical Chemistry and Laboratory Medicine, Department of Medicine, Reproductive and Adult Endocrinology Program, Urologic Oncology Branch, Department of Clinical Pathophysiology, Department of Clinical Physiology, Department of Laboratory Medicine and Pathology, Endocrinology, Internal Medicine, University of Dresden, 01307 Dresden, Germany

Search for other papers by Jacques W M Lenders in
Google Scholar
PubMed
Close

Introduction Phaeochromocytomas and paragangliomas (PPGLs) are heterogeneous tumours with highly variable signs and symptoms and diverse clinical presentations ( Manger 2009 ). Much of the heterogeneity is due to wide-ranging variations in the types

Free access
Dewi Astuti Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Dewi Astuti in
Google Scholar
PubMed
Close
,
Christopher J Ricketts Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Christopher J Ricketts in
Google Scholar
PubMed
Close
,
Rasheduzzaman Chowdhury Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Rasheduzzaman Chowdhury in
Google Scholar
PubMed
Close
,
Michael A McDonough Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Michael A McDonough in
Google Scholar
PubMed
Close
,
Dean Gentle Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Dean Gentle in
Google Scholar
PubMed
Close
,
Gail Kirby Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Gail Kirby in
Google Scholar
PubMed
Close
,
Susanne Schlisio Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Susanne Schlisio in
Google Scholar
PubMed
Close
,
Rajappa S Kenchappa Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Rajappa S Kenchappa in
Google Scholar
PubMed
Close
,
Bruce D Carter Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Bruce D Carter in
Google Scholar
PubMed
Close
,
William G Kaelin Jr Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by William G Kaelin Jr in
Google Scholar
PubMed
Close
,
Peter J Ratcliffe Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Peter J Ratcliffe in
Google Scholar
PubMed
Close
,
Christopher J Schofield Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Christopher J Schofield in
Google Scholar
PubMed
Close
,
Farida Latif Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Farida Latif in
Google Scholar
PubMed
Close
, and
Eamonn R Maher Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK
Centre for Rare Diseases and Personalised Medicine, CRUK Renal Molecular Oncology Group, Chemistry Research Laboratory, Howard Hughes Medical Institute, Oxygen Sensing and Cancer Laboratory, Department of Biochemistry and Center for Molecular Neuroscience, Henry Wellcome Building for Molecular Physiology, West Midlands Regional Genetics Service, University of Birmingham, Birmingham B15 2TT, UK

Search for other papers by Eamonn R Maher in
Google Scholar
PubMed
Close

Introduction Germline mutations in the von Hippel–Lindau ( VHL ) tumour suppressor gene and in the B, C and D subunits of succinate dehydrogenase ( SDHB , SDHC and SDHD ) are strongly linked with susceptibility to phaeochromocytoma ( Latif et al

Open access
C D E Margetts
Search for other papers by C D E Margetts in
Google Scholar
PubMed
Close
,
D Astuti
Search for other papers by D Astuti in
Google Scholar
PubMed
Close
,
D C Gentle
Search for other papers by D C Gentle in
Google Scholar
PubMed
Close
,
W N Cooper
Search for other papers by W N Cooper in
Google Scholar
PubMed
Close
,
A Cascon
Search for other papers by A Cascon in
Google Scholar
PubMed
Close
,
D Catchpoole
Search for other papers by D Catchpoole in
Google Scholar
PubMed
Close
,
M Robledo
Search for other papers by M Robledo in
Google Scholar
PubMed
Close
,
H P H Neumann
Search for other papers by H P H Neumann in
Google Scholar
PubMed
Close
,
F Latif
Search for other papers by F Latif in
Google Scholar
PubMed
Close
, and
E R Maher
Search for other papers by E R Maher in
Google Scholar
PubMed
Close

Introduction Phaeochromocytomas are catecholamine-producing tumours that usually arise within the adrenal medulla but are extra-adrenal in 10% of cases. Hypertension is the most consistent clinical feature of phaeochromocytoma and

Free access
Esther Korpershoek Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Esther Korpershoek in
Google Scholar
PubMed
Close
,
Nanne K Kloosterhof Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Nanne K Kloosterhof in
Google Scholar
PubMed
Close
,
Angelique Ziel-van der Made Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Angelique Ziel-van der Made in
Google Scholar
PubMed
Close
,
Hanneke Korsten Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Hanneke Korsten in
Google Scholar
PubMed
Close
,
Lindsey Oudijk Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Lindsey Oudijk in
Google Scholar
PubMed
Close
,
Jan Trapman Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Jan Trapman in
Google Scholar
PubMed
Close
,
Winand N M Dinjens Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Winand N M Dinjens in
Google Scholar
PubMed
Close
, and
Ronald R de Krijger Departments of Pathology, Neurology, Department of Paediatric Oncology and Haematology, Josephine Nefkens Institute, Erasmus Medical Centre, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Search for other papers by Ronald R de Krijger in
Google Scholar
PubMed
Close

Introduction In humans, phaeochromocytomas (PCCs) are relatively rare tumours that occur in the adrenal medulla and usually overproduce catecholamines, such as adrenaline or noradrenaline ( Lenders et al . 2005 ). This overproduction causes high

Free access
Anna Angelousi Department of Pathophysiology, Sector of Endocrinology, National & Kapodistrian University of Athens, Athens, Greece

Search for other papers by Anna Angelousi in
Google Scholar
PubMed
Close
,
Georgios K Dimitriadis Division of Translational and Experimental Medicine, University of Warwick Medical School, Clinical Sciences Research Laboratories, Coventry, UK

Search for other papers by Georgios K Dimitriadis in
Google Scholar
PubMed
Close
,
Georgios Zografos Third Department of Surgery, Athens General Hospital “Georgios Gennimatas”, Athens, Greece

Search for other papers by Georgios Zografos in
Google Scholar
PubMed
Close
,
Svenja Nölting Department of Internal Medicine II, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

Search for other papers by Svenja Nölting in
Google Scholar
PubMed
Close
,
Gregory Kaltsas Department of Pathophysiology, Sector of Endocrinology, National & Kapodistrian University of Athens, Athens, Greece
Division of Translational and Experimental Medicine, University of Warwick Medical School, Clinical Sciences Research Laboratories, Coventry, UK
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK

Search for other papers by Gregory Kaltsas in
Google Scholar
PubMed
Close
, and
Ashley Grossman Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK

Search for other papers by Ashley Grossman in
Google Scholar
PubMed
Close

, Lenders et al. 2014 ). Adrenocortical carcinomas (ACCs) account for up to 11% (range 1.2–12%) of adrenocortical tumours, whereas up to 25% of phaeochromocytomas (PCs) may become malignant ( Ayala-Ramirez et al. 2011 , Fassnacht et al. 2016

Free access
Rui M B Maciel Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo Escola Paulista de Medicina, São Paulo, São Paulo, Brazil

Search for other papers by Rui M B Maciel in
Google Scholar
PubMed
Close
,
Larissa V Bim Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo Escola Paulista de Medicina, São Paulo, São Paulo, Brazil

Search for other papers by Larissa V Bim in
Google Scholar
PubMed
Close
,
Cleber P Camacho Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo Escola Paulista de Medicina, São Paulo, São Paulo, Brazil

Search for other papers by Cleber P Camacho in
Google Scholar
PubMed
Close
, and
Janete M Cerutti Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo Escola Paulista de Medicina, São Paulo, São Paulo, Brazil

Search for other papers by Janete M Cerutti in
Google Scholar
PubMed
Close

Dear Editor, In a recent issue of Endocrine-Related Cancer , Castinetti et al . reported a different natural history of phaeochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) patients between Europe and South America ( Castinetti

Free access
Emma R Woodward Section of Medical and Molecular Genetics and Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Institute of Biomedical Research, Birmingham B15 2TT, UK and West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham B15 2TG, UK

Search for other papers by Emma R Woodward in
Google Scholar
PubMed
Close
and
Eamonn R Maher Section of Medical and Molecular Genetics and Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Institute of Biomedical Research, Birmingham B15 2TT, UK and West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham B15 2TG, UK

Search for other papers by Eamonn R Maher in
Google Scholar
PubMed
Close

Introduction Although the first descriptions of von Hippel-Lindau (VHL) disease were in the 19th century, phaeochromocytoma was first associated with VHL disease only about 50 years ago ( Glushien et al. 1953 ). Traditionally, an

Free access
Umasuthan Srirangalingam
Search for other papers by Umasuthan Srirangalingam in
Google Scholar
PubMed
Close
,
Bernard Khoo
Search for other papers by Bernard Khoo in
Google Scholar
PubMed
Close
,
Lisa Walker Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Lisa Walker in
Google Scholar
PubMed
Close
,
Fiona MacDonald Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Fiona MacDonald in
Google Scholar
PubMed
Close
,
Robert H Skelly Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Robert H Skelly in
Google Scholar
PubMed
Close
,
Emad George Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Emad George in
Google Scholar
PubMed
Close
,
David Spooner Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by David Spooner in
Google Scholar
PubMed
Close
,
Linda B Johnston
Search for other papers by Linda B Johnston in
Google Scholar
PubMed
Close
,
John P Monson
Search for other papers by John P Monson in
Google Scholar
PubMed
Close
,
Ashley B Grossman
Search for other papers by Ashley B Grossman in
Google Scholar
PubMed
Close
,
W M Drake
Search for other papers by W M Drake in
Google Scholar
PubMed
Close
,
Scott A Akker
Search for other papers by Scott A Akker in
Google Scholar
PubMed
Close
,
Patrick J Pollard Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Patrick J Pollard in
Google Scholar
PubMed
Close
,
Nick Plowman Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Nick Plowman in
Google Scholar
PubMed
Close
,
Norbert Avril Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Norbert Avril in
Google Scholar
PubMed
Close
,
Daniel M Berney Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Daniel M Berney in
Google Scholar
PubMed
Close
,
Jacky M Burrin Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Jacky M Burrin in
Google Scholar
PubMed
Close
,
Rodney H Reznek Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Rodney H Reznek in
Google Scholar
PubMed
Close
,
V K Ajith Kumar Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by V K Ajith Kumar in
Google Scholar
PubMed
Close
,
Eamonn R Maher Department of Endocrinology, Department of Clinical Genetics, Department of Medical and Molecular Genetics, Department of Medicine, Department of Medicine, Oncology Centre, Henry Wellcome Building for Molecular Physiology, Radiation Oncology, Center for Cancer Imaging, Cellular Pathology, Clinical Biochemistry, Clinical Genetics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK

Search for other papers by Eamonn R Maher in
Google Scholar
PubMed
Close
, and
Shern L Chew
Search for other papers by Shern L Chew in
Google Scholar
PubMed
Close

Introduction Recent studies have shown that ∼25% of apparently sporadic phaeochromocytomas and paragangliomas are due to germ line mutations in one of several familial syndrome genes, including von Hippel-Lindau ( VHL ), RET , succinate

Free access
Joanna Grey Association for Multiple Endocrine Neoplasia Disorders (AMEND), Tunbridge Wells, Kent, UK

Search for other papers by Joanna Grey in
Google Scholar
PubMed
Close
and
Kym Winter Association for Multiple Endocrine Neoplasia Disorders (AMEND), Tunbridge Wells, Kent, UK

Search for other papers by Kym Winter in
Google Scholar
PubMed
Close

MEN3). MEN2 predisposes patients to medullary thyroid cancer (99%) and phaeochromocytoma (50%) but also to other conditions according to specific genotype. MEN2A also includes a 25% risk of developing parathyroid hyperplasia and is now recognised as 4

Free access