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Stefan J Barfeld Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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Harri M Itkonen Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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Alfonso Urbanucci Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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Ian G Mills Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway
Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway
Prostate Cancer Research Group Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

Department of Cancer Prevention Institute of Cancer Research

Department of Urology Oslo University Hospital, N-0424 Oslo, Norway

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) ( DeBerardinis et al . 2008 ). It is therefore not surprising that metabolic adaptations have been reported in various human cancers ( Hsu & Sabatini 2008 ). Metabolic status of the prostate gland and cancer predisposition The prostate gland is principally

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-13-0515
Volume/Issue:
Volume 21: Issue 4
Free access
Shane Stegeman School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

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Leire Moya School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

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Luke A Selth School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia
School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

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Amanda B Spurdle School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

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Judith A Clements School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

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Jyotsna Batra School of Biomedical Sciences, Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Molecular Cancer Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre – Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, Australia

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Introduction Globally, prostate cancer is the second most common cancer in men ( Siegel et al . 2014 ), with a significant proportion of cases attributed to heritable genetic conditions ( Siegel et al . 2014 ) that influence not only cancer

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0013
Volume/Issue:
Volume 22: Issue 2
Free access
A Berruti
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A Mosca
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M Tucci
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C Terrone
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M Torta
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R Tarabuzzi
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L Russo
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C Cracco
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E Bollito
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R M Scarpa
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A Angeli
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L Dogliotti
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Introduction Prostate cancer is frequent in the aging male population ( De Angelis et al. 1997 ). Androgen suppression by either orchiectomy or administration of luteinizing hormone-releasing hormone analogs (LHRH-As) is the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00876
Volume/Issue:
Volume 12: Issue 1
Free access
Y Dong
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L T Bui
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D M Odorico
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O L Tan
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S A Myers
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H Samaratunga
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R A Gardiner
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J A Clements
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Introduction Prostate cancer is the most common non-skin malignancy and the second leading cause of cancer death in males in the USA and other Western countries ( Jemal et al. 2004 ). Prostate-specific antigen (PSA), also known as

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01062
Volume/Issue:
Volume 12: Issue 4
Free access
Alastair Davies Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, British Columbia, Canada

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Amina Zoubeidi Vancouver Prostate Centre, Vancouver, British Columbia, Canada
Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, British Columbia, Canada

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Luke A Selth Flinders Centre for Innovation in Cancer, Flinders University, College of Medicine and Public Health, Bedford Park, South Australia, Australia
Dame Roma Mitchell Cancer Research Laboratories and Freemasons Foundation Centre for Men’s Health, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia

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Introduction The androgen receptor (AR) is the principal driver of prostate cancer development and resistance; accordingly, AR pathway inhibitors (ARPIs) are used to treat men at all stages of the disease. Drug resistance ultimately ensues

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0420
Volume/Issue:
Volume 27: Issue 2
Free access
Margaret M Centenera Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia
Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Sarah L Carter Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Joanna L Gillis Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia
Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Deborah L Marrocco-Tallarigo Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Randall H Grose Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Lisa M Butler Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia
Dame Roma Mitchell Cancer Research Laboratories, South Australian Health and Medical Research Institute, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia

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Introduction Androgen deprivation therapy (ADT) is used palliatively to control tumor growth and metastasis in men with locally advanced prostate cancer ( Labrie 2011 ). Despite an initial response to ADT, the majority of patients will

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0541
Volume/Issue:
Volume 22: Issue 5
Free access
Varinder Jeet Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Gregor Tevz Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Brett Hollier Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Colleen Nelson Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Introduction Each year, more than 258 000 men will die of prostate cancer (PCa), making PCa the second largest cause of cancer-related mortality in males globally ( Jemal et al . 2011 , Siegel et al . 2012 ). While early-stage PCa can be

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0267
Volume/Issue:
Volume 21: Issue 5
Open access
Lisa K Philp Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Anja Rockstroh Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia
Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada

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Martin C Sadowski Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Nenad Bartonicek Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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John D Wade Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
School of Chemistry, University of Melbourne, Melbourne, Victoria, Australia

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Laszlo Otvos Jr OLPE, LLC, Audubon, Pennsylvania, USA
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary

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Colleen C Nelson Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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, lipodystrophy and hypertension, irrespective of BMI. Prostate cancer (PCa) patients are reported to have lower circulating adiponectin compared to men with a non-malignant prostate ( Goktas et al. 2005 , Michalakis et al. 2007 , Arisan et al. 2009 ) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0297
Volume/Issue:
Volume 27: Issue 12
Restricted access
Stefano Mangiola Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Division of Bioinformatics, Walter and Eliza Hall Institute, Parkville, Victoria, Australia

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Ryan Stuchbery Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Geoff Macintyre Centre for Neural Engineering, Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
Diagnostic Genomics, NICTA, Victoria Research Laboratory, The University of Melbourne, Parkville, Victoria, Australia

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Michael J Clarkson Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Justin S Peters Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Anthony J Costello Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Christopher M Hovens Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Niall M Corcoran Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia

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Introduction Prostate cancer is the most widely diagnosed cancer among men in developed countries and the second most diagnosed cancer in men worldwide ( Torre et al . 2015 ). The widespread use of serum PSA measurement as an ad hoc community

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0058
Volume/Issue:
Volume 25: Issue 5
Free access
Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Anja Rockstroh Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Martin C Sadowski Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Atefeh Taherian Fard Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Gregor Tevz Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Michelle S Libério Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Charles L Bidgood Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Jennifer H Gunter Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Stephen McPherson Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Nenad Bartonicek Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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John D Wade Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
School of Chemistry, University of Melbourne, Melbourne, Victoria, Australia

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Laszlo Otvos OLPE, LLC, Audubon, Pennsylvania, USA
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary

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Colleen C Nelson Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Introduction Prostate cancer (PCa) is androgen-dependent and consequently drugs inhibiting multiple facets of the androgen axis are used as therapeutics ( Harris et al. 2009 ). However, in advanced PCa, tumours develop mechanisms to escape

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0405
Volume/Issue:
Volume 28: Issue 5
Restricted access