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The Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki, Finland
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The Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki, Finland
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The Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki, Finland
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substantial amount of evidence has implicated S1P in the progression of several types of cancers by enhancing many central events such as proliferation, angiogenesis, migration, and invasion ( Alvarez et al . 2007 , Strub et al . 2010 , Alshaker et al
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al. 2018 ). Given that they influence such a broad range of processes, it is not surprising that growing clinical and experimental evidence suggests that they are also implicated in cancer development and progression, affecting cancer cell
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Section of Hematology/Oncology, Genomic Medicine Institute, Department of Genetics and Genome Sciences, Endocrine Surgery Research Program, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
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Introduction A cancer of a different site and histologic type that develops in a person who already has a cancer diagnosis is considered a second primary cancer. Certain primary cancers are associated with a high risk of developing a second primary
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Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway
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Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway
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Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway
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autonomic regulation ( Coussens & Werb 2002 , Wallach et al. 2014 ) where dysregulation can result in chronic low-grade inflammation, a known risk for the development and progression of cancer ( Coussens & Werb 2002 ). In the oncology setting
Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland
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Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland
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Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland
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Functional Foods Forum, University of Turku, Turku, Finland
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Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland
Center for Bone and Arthitis Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Introduction Androgens play a crucial role in the normal development and growth of the prostate and the growth of prostate cancer. The prostate tissue is known for the local biosynthesis of dihydrotestosterone (DHT), which is the principal
Department of Physiology and Cell Biology, The Ohio State Biochemistry Graduate Program, The Integrated Biomedical Science Graduate Program, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, Ohio 43210, USA
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Department of Physiology and Cell Biology, The Ohio State Biochemistry Graduate Program, The Integrated Biomedical Science Graduate Program, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, Ohio 43210, USA
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Department of Physiology and Cell Biology, The Ohio State Biochemistry Graduate Program, The Integrated Biomedical Science Graduate Program, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, Ohio 43210, USA
Department of Physiology and Cell Biology, The Ohio State Biochemistry Graduate Program, The Integrated Biomedical Science Graduate Program, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, Ohio 43210, USA
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Introduction Breast cancer is the most common type of cancer in women living in the United States and is the second most common cause of cancer death in women ( American Cancer Society 2012 ). Because of routine clinical examination and increased
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Molecular and Cellular Biology Program, Ohio University, Athens, Ohio, USA
Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Introduction Resistance to therapy is one of the major hurdles in tackling cancer – the second highest causal factor for all-cause, all-age human mortality in the United States between the period of 2001 and 2020, as per the Center for Disease
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Queensland Institute of Medical Research, School of Public Health, Department of Preventive Medicine, Department of Epidemiology and Biostatistics, Program in Epidemiology, Obstetrics and Gynecology Epidemiology Center, Peter MacCallum Cancer Centre, Department of Epidemiology and Public Health, Cancer Epidemiology Program, Division of Cancer Epidemiology, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Department of Obstetrics and Gynecology, Roswell Park Cancer Center, Virus, Gynecologic Clinic, Department of Health Sciences Research, Department of Community and Family Medicine, Robert Wood Johnson Medical School, School of Public Health, National Cancer Institute, Division of Genetics and Epidemiology, Department of Cancer Epidemiology and Prevention, Department of Epidemiology, Department of Gynaecological Oncology, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, Queensland 4029, Australia
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Queensland Institute of Medical Research, School of Public Health, Department of Preventive Medicine, Department of Epidemiology and Biostatistics, Program in Epidemiology, Obstetrics and Gynecology Epidemiology Center, Peter MacCallum Cancer Centre, Department of Epidemiology and Public Health, Cancer Epidemiology Program, Division of Cancer Epidemiology, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Department of Obstetrics and Gynecology, Roswell Park Cancer Center, Virus, Gynecologic Clinic, Department of Health Sciences Research, Department of Community and Family Medicine, Robert Wood Johnson Medical School, School of Public Health, National Cancer Institute, Division of Genetics and Epidemiology, Department of Cancer Epidemiology and Prevention, Department of Epidemiology, Department of Gynaecological Oncology, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, Queensland 4029, Australia
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Queensland Institute of Medical Research, School of Public Health, Department of Preventive Medicine, Department of Epidemiology and Biostatistics, Program in Epidemiology, Obstetrics and Gynecology Epidemiology Center, Peter MacCallum Cancer Centre, Department of Epidemiology and Public Health, Cancer Epidemiology Program, Division of Cancer Epidemiology, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Department of Obstetrics and Gynecology, Roswell Park Cancer Center, Virus, Gynecologic Clinic, Department of Health Sciences Research, Department of Community and Family Medicine, Robert Wood Johnson Medical School, School of Public Health, National Cancer Institute, Division of Genetics and Epidemiology, Department of Cancer Epidemiology and Prevention, Department of Epidemiology, Department of Gynaecological Oncology, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, Queensland 4029, Australia
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Introduction It is widely accepted that being overweight or obese increases a woman's risk of developing endometrial and post-menopausal breast cancer ( Calle & Kaaks 2004 ). The association with ovarian cancer is less clear, largely because
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Introduction Treatment of hormone-dependent prostate cancer by androgen ablation is usually initially successful, reducing primary tumour burden and increasing 5-year survival rates. Currently, androgen ablation is achieved using orchidectomy
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conceptual advances in the field over this period, with a spotlight on its impact on the field of cancer therapeutics. Microtubules (MTs) are polarized long hollow cylindrical structures comprising of α- and β-tubulin heterodimers. These heterodimers of 50