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Kjell Öberg University Hospital, Uppsala, Sweden

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Steven W J Lamberts Erasmus Medical Center, Rotterdam, The Netherlands

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Introduction Somatostatin analogues are the current mainstay treatment for acromegaly and gastroenteropancreatic neuroendocrine tumours (GEP-NET). Acromegaly: background Acromegaly is a chronic metabolic disorder with an estimated

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0151
Volume/Issue:
Volume 23: Issue 12
Free access
Dermot O'Toole Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland
Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Anne Couvelard Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland
Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Vinciane Rebours Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Magali Zappa Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Olivia Hentic Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Pascal Hammel Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Philippe Levy Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Pierre Bedossa Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland
Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Eric Raymond Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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Philippe Ruszniewski Department of Clinical Medicine and Gastroenterology, Service de Gastroentérologie, Service d'Anatomie Pathologique, INSERM U773, Service de Radiologie, Service d'Oncologie Bichat-Beaujon, St James's Hospital and Trinity College Dublin, James's Street, Dublin 8, Ireland

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responses to cytotoxics in patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) vary with best responses attributable to streptozotocin-based regimens especially in pancreatic GEP ( O'Toole et al . 2004 , O'Toole 2006 ). Nonetheless

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0204
Volume/Issue:
Volume 17: Issue 4
Free access
Eva-Maria Duerr Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Yusuke Mizukami Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Aylwin Ng Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Ramnik J Xavier Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Hirotoshi Kikuchi Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Vikram Deshpande Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Andrew L Warshaw  Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Jonathan Glickman Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Matthew H Kulke Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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Daniel C Chung Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology
Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Department of Surgery, Department of Pathology, Department of Adult Oncology

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11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases . Journal of Clinical Endocrinology and Metabolism 91 4070 – 4076 . Kloppel G Perren A Heitz PU 2004 The gastroenteropancreatic neuroendocrine cell system

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0194
Volume/Issue:
Volume 15: Issue 1
Free access
Rushabh Gujarathi Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Sara Abou Azar Section of Endocrine Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA

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Joseph Tobias Section of Endocrine Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA

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Blase N Polite Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Namrata Setia Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Nicholas Feinberg Department of Radiology, University of Chicago, Chicago, Illinois, USA

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Daniel E Appelbaum Department of Radiology, University of Chicago, Chicago, Illinois, USA

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Xavier M Keutgen Section of Endocrine Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA

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Chih-Yi Liao Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Introduction Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs), the most common type of neuroendocrine neoplasms, are often metastatic at the time of presentation ( Yao et al. 2008 , Dasari et al. 2017 ). Peptide

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-24-0065
Volume/Issue:
Volume 31: Issue 11
Restricted access
Mark Kidd Wren Laboratories, 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Ignat Drozdov Wren Laboratories, 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Irvin Modlin Wren Laboratories, 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Introduction Biomarker assessment of gastroenteropancreatic neuroendocrine tumor (GEP–NET) disease has been difficult since the default is provided by a monoanalyte measurement, chromogranin A, which has well-described limitations ( Lawrence et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0092
Volume/Issue:
Volume 22: Issue 4
Free access
Irvin M Modlin Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Ignat Drozdov Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Daniele Alaimo Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Stephen Callahan Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Nancy Teixiera Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Lisa Bodei Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Mark Kidd Wren Laboratories 35 NE Industrial Road, Branford, Connecticut 06405, USA

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Introduction Critical requirements for the management of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) include methods that efficiently detect and monitor tumor behavior ( Modlin et al . 2008 a ). NETs are, however, a heterogeneous group

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0190
Volume/Issue:
Volume 21: Issue 4
Free access
Martin B Niederle
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Monika Hackl Division of General Surgery, Bundesanstalt ‘Statistik Österreich’ (Austria Statistics), Department of Clinical Pathology, Section of Endocrine Surgery, Department of Surgery, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria

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Klaus Kaserer Division of General Surgery, Bundesanstalt ‘Statistik Österreich’ (Austria Statistics), Department of Clinical Pathology, Section of Endocrine Surgery, Department of Surgery, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria

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Bruno Niederle
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gastroenteropancreatic (GEP) NETs ( Kloppel et al . 2004 ); they were formerly referred to as gastrointestinal carcinoids, a term introduced by Oberndorfer more than 100 years ago ( Kloppel 2007 a , Modlin et al . 2007 ). NETs were recently classified according to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0152
Volume/Issue:
Volume 17: Issue 4
Free access
Kjell Oberg Department of Endocrine Oncology, University Hospital, Entrance 78, SE-751 85 Uppsala, Sweden

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Introduction The clinical presentation of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) varies according to the site and size of the primary tumour, the presence or absence of metastatic spread, whether associated features compatible with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0280
Volume/Issue:
Volume 18: Issue S1
Free access
Mohid S Khan Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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Martyn E Caplin Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, 10th Floor, London NW3 2QG, UK

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hemihepatectomy. Intra-operative ultrasonography is essential in detecting all metastases. Surgery can be proposed in all patients with gastroenteropancreatic-NETs (GEP-NETs) regardless of the site of primary, although resection with metastatic hindgut NETs is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0271
Volume/Issue:
Volume 18: Issue S1
Free access
Elke Tatjana Aristizabal Prada Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Vera Heinzle Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Thomas Knösel Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany

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Svenja Nölting Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Gerald Spöttl Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Julian Maurer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Christine Spitzweg Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Martin Angele Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Nina Schmidt Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Felix Beuschlein Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland

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Günter K Stalla Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany

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Rainer Blaser Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Klaus A Kuhn Institute of Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Christoph J Auernhammer Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Campus Grosshadern, Munich, Germany
Department of Internal Medicine 2, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany
Department of Internal Medicine 4, University-Hospital, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Munich, Germany

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Introduction Neuroendocrine tumors (NETs) are highly heterogeneous tumors originating from distinct cell precursors ( Schimmack et al . 2011 ). Current data show an increase in incidence of gastroenteropancreatic neuroendocrine tumors (GEP

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0201
Volume/Issue:
Volume 25: Issue 5
Free access