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Federica Morani Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Rossella Titone Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Loredana Pagano Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Alessandra Galetto Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Oscar Alabiso Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Gianluca Aimaretti Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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Ciro Isidoro Laboratory of Molecular Pathology, Unit of Oncology, Department of Health Sciences

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and oncosuppressor genes regulate the induction of autophagy. Autophagy is also epigenetically regulated through the methylation of autophagy regulatory genes, the activity of histone deacetylases (HDAC), and the expression of microRNAs (miRNAs). Here

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Helen C Miller Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Adam E Frampton Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Anna Malczewska Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK
Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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Silvia Ottaviani Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Euan A Stronach Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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Rashpal Flora Department of Histopathology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK

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Daniel Kaemmerer Zentralklinik Bad Berka GmbH, Robert-Koch-Allee, Bad Berka, Germany

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Gert Schwach Institute of Pathophysiology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Roswitha Pfragner Institute of Pathophysiology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria

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Omar Faiz St Mark’s Hospital, Harrow, UK

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Beata Kos-Kudła Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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George B Hanna Academic Surgical Unit, Department of Surgery and Cancer, Imperial College, St Mary’s Campus, London, UK

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Justin Stebbing Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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Leandro Castellano Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

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Andrea Frilling Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK

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individualised treatment and monitor treatment efficacy is a key issue in management of NETs ( Modlin et al . 2008 , Frilling et al . 2014 ). MicroRNAs (miRNAs) are small endogenous noncoding RNAs ~17–25 nucleotides in length that play important post

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Goswin Y Meyer-Rochow Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Nicole E Jackson Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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John V Conaglen Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Denis E Whittle Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Muthusamy Kunnimalaiyaan Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Herbert Chen Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Gunnar Westin Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Johanna Sandgren Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Peter Stålberg Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Elham Khanafshar Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Daniel Shibru Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Quan-Yang Duh Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Orlo H Clark Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Electron Kebebew Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Anthony J Gill Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Rory Clifton-Bligh Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Bruce G Robinson Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Diana E Benn Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Stan B Sidhu Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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disease have the potential to significantly improve the outcome for patients with malignant pheochromocytoma. MicroRNAs (miRNAs) are a class of small non-protein-coding RNAs (∼22 bp) that negatively regulate protein expression. These single stranded RNA

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Zsófia Tömböl
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Peter M Szabó
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Viktor Molnár Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Zoltán Wiener Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Gergely Tölgyesi Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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János Horányi Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Peter Riesz Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Peter Reismann
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Attila Patócs Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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István Likó Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Rolf-Christian Gaillard Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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András Falus Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary
Second Department of Medicine, Department of Genetics, First Department of Surgery, Department of Urology, Molecular Medicine Research Group, Gedeon Richter Ltd, Division of Endocrinology, Research Group of Inflammation Biology and Immunogenomics, Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, H-1088 Budapest, Hungary

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Károly Rácz
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Peter Igaz
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be relevant in adrenocortical tumor pathogenesis ( Igaz et al . 2006 ). To our knowledge, no studies investigating potential differences between microRNA (miR) expression patterns of various sporadic adrenocortical tumors have been published to date

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E Patterson
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R Webb
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A Weisbrod
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B Bian
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M He
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L Zhang
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A K Holloway Endocrine Oncology Section, Gladstone Institutes, Program in Reproductive and Adult Endocrinology, NIH/NCI/Surgery Branch, National Cancer Institute, NIH, Hatfield Clinical Research Center, Room 4‐5952, 10 Center Drive, Bethesda, Maryland 20892, USA

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R Krishna
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N Nilubol
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K Pacak Endocrine Oncology Section, Gladstone Institutes, Program in Reproductive and Adult Endocrinology, NIH/NCI/Surgery Branch, National Cancer Institute, NIH, Hatfield Clinical Research Center, Room 4‐5952, 10 Center Drive, Bethesda, Maryland 20892, USA

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E Kebebew
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are poorly understood. MicroRNAs (miRNAs) are short, noncoding RNAs that posttranscriptionally regulate gene expression by sequence-specific targeting of mRNAs. miRNAs have roles in diverse biological processes, such as differentiation, cellular growth

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Guy Wayne Novotny
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Kirstine C Belling Department of Growth and Reproduction, Center for Biological Sequence Analysis, Department of Molecular Biology, Steno Diabetes Center A/S, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

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Jesper Bertram Bramsen Department of Growth and Reproduction, Center for Biological Sequence Analysis, Department of Molecular Biology, Steno Diabetes Center A/S, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

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John E Nielsen
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Jette Bork-Jensen Department of Growth and Reproduction, Center for Biological Sequence Analysis, Department of Molecular Biology, Steno Diabetes Center A/S, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

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Kristian Almstrup
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Si Brask Sonne
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Jørgen Kjems Department of Growth and Reproduction, Center for Biological Sequence Analysis, Department of Molecular Biology, Steno Diabetes Center A/S, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

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Ewa Rajpert-De Meyts
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Henrik Leffers
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through a class of small RNAs, microRNAs (miRNAs). Most miRNAs specifically inhibit translation of mRNAs through binding to complementary sequences in the 3′-UTR ( Lai 2002 , Bartel 2004 , Xie et al . 2005 ), while some can enhance translation through

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Carolyn M Klinge Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA

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RNA that have important regulatory roles in cellular biology were discovered: short nuclear and small nucleolar RNAs (snRNAs and snoRNAs), followed by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The Encyclopedia of DNA Elements (ENCODE

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Deniz M Özata Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Stefano Caramuta Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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David Velázquez-Fernández Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Pinar Akçakaya Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Hong Xie Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Anders Höög Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Martin Bäckdahl Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Catharina Larsson Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Weng-Onn Lui Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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of metastatic ACC disease and adverse outcome are presently lacking in routine diagnostics. Profilings of mRNA and microRNA (miRNA) expressions in human cancer have revealed important alterations that do not only have possible diagnostic and

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Aparna Lakshmanan Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA
Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA

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Anna Wojcicka Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA
Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA

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Marta Kotlarek Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA

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Xiaoli Zhang Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA

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Krystian Jazdzewski Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA
Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA

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Sissy M Jhiang Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA
Department of Physiology and Cell Biology, Molecular, Genomic Medicine, Laboratory of Human Cancer Genetics, Center for Biostatistics, Cellular and Developmental Biology Graduate Program, The Ohio State University, 1645 Neil Avenue, 304 Hamilton Hall, Columbus, Ohio 43210, USA

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/absent expression/function of NIS. microRNA (miR) has emerged as a promising therapeutic target in many diseases ( Maqbool & Hussain 2014 ). However, the role of miRs in NIS-mediated RAIU has not been investigated. miRs predominantly bind to 3′UTR of target genes

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Andrea Perra Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

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Michelina Plateroti Cancer Research Center of Lyon INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon Bérard, Département de la Recherche, Lyon, France

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Amedeo Columbano Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

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. Thus, whether hypermethylation occurs in human HCC and plays a role in the downregulation of TRβ1 observed in these tumours still remains an unsolved question. microRNA microRNAs (miRNAs) are small non-coding RNAs, which negatively control gene

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