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Yushan Mao Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Maryland, MD, USA

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Mingzhao Xing Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Maryland, MD, USA

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: 8050 (papillary carcinoma not otherwise specified, NOS), 8260 (papillary adenocarcinoma, NOS), 8343 (papillary carcinoma, encapsulated), and 8341 (papillary microcarcinoma); (ii) FVPTC: 8340 (papillary carcinoma, follicular variant); and (iii) other

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Paola Caria Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Tinuccia Dettori Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Daniela V Frau Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Angela Borghero Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Antonello Cappai Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Alessia Riola Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Maria L Lai Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Francesco Boi Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Piergiorgio Calò Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Angelo Nicolosi Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Stefano Mariotti Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Roberta Vanni Departments of Biomedical Sciences, Medical Sciences ‘M. Aresu’, Surgical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (Cagliari), Italy

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Fidler JP Giordano TJ Biddinger PW Nikiforov YE 2006 Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas . American Journal of Surgical

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Henry Crayton Department of Endocrine Surgery, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia
Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia

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Katherine Wu Department of Endocrinology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia

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David Leong Department of Endocrine Surgery, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia

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Nazim Bhimani The Kinghorn Cancer Centre, Garvan Institute of Medical Research, St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia

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Matti Gild Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
Department of Endocrinology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia

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Anthony Glover Department of Endocrine Surgery, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, New South Wales, Australia
Northern Clinical School, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia

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-015-3021-9 ) Albareda M Puig-Domingo M Wengrowicz S Soldevila J Matias-Guiu X Caballero A Chico A & De Leiva A 1998 Clinical forms of presentation and evolution of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular

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L Fugazzola
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in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. Clinical Cancer Research 4 223 –228. Carta C , Moretti S, Passeri L, Barbi F, Avenia N, Cavaliere A, Monacelli M

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Gustavo Penna Department of Clinical Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil

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Ileana G S Rubio Department of Biological Science, Molecular Thyroid Science Laboratory, Federal University of São Paulo, São Paulo, Brazil
Biotechnology Post-graduation Program, Federal University of São Paulo, São Paulo, Brazil
Estructural and Functional Biology Program, Federal University of São Paulo, São Paulo, Brazil

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Ester Saraiva Brust Department of Biological Science, Molecular Thyroid Science Laboratory, Federal University of São Paulo, São Paulo, Brazil
Biotechnology Post-graduation Program, Federal University of São Paulo, São Paulo, Brazil

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Juliana Cazarin Laboratory of Endocrine Physiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Fabio Hecht Laboratory of Endocrine Physiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Nina Ramalho Alkmim Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil
Post-Graduation Program Molecular Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil

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Kamilla M A Brandão Rajão Endocrinology Service of Institute Orizonti, Belo Horizonte, Minas Gerais, Brazil
Endocrinology Service of Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil

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Helton Estrela Ramos Department of Bioregulation, Health & Science Institute, Thyroid Study Laboratory, Federal University of Bahia, Salvador, Brazil
Post-Graduation Program Medicine and Health, Faculty of Medical Sciences, Federal University of Bahia, Salvador, Bahia, Brazil
Post-Graduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Bahia, Brazil

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 Exaggerated papillary infoldings of hyperplastic follicles mimicking papillary carcinoma  Representative stromal fragments of fibrosis  Background with thin colloid or decreased to absent colloid  Nuclei with anisonucleosis, mild enlargement

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Arja Jukkola
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Risto Bloigu
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Tapani Ebeling
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Pasi Salmela
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Guillermo Blanco
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. The majority of the patients were women (82%) (Table 1 ), and the mean age was 47 years (range 14–86). The mean age of the patients with papillary carcinoma was 46 years (range 14–86), that of the follicular carcinoma group was 50 years (range 19

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Hong-Jun Song Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Yan-Li Xue Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Yan-Hong Xu Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Zhong-Ling Qiu Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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Quan-Yong Luo Department of Nuclear Medicine, Postgraduate Department, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China

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. Journal of Clinical Endocrinology and Metabolism 89 5303 – 5307 . doi:10.1210/jc.2004-0757 . Brogioni S Viacava P Tomisti L Martino E Macchia E 2007 A special case of bilateral ovarian metastases in a woman with papillary carcinoma of

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Stéphanie Durand Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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Carole Ferraro-Peyret Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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Mireille Joufre Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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Annie Chave Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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Françoise Borson-Chazot Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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Samia Selmi-Ruby Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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Bernard Rousset Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France
Institut National de la Santé et de la Recherche Médicale, Université Lyon 1, Unité Fonctionnelle de Biologie Cellulaire, UMR 664, Lyon F-69372, France

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microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas . American Journal of Surgical Pathology 30 216 – 222 . Aldred MA Huang Y Liyanarachchi S Pellegata NS Gimm O Jhiang S Davuluri RV

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Vincenzo Marotta IOS & COLEMAN Srl, Naples, Italy

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Concetta Sciammarella IOS & COLEMAN Srl, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

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Antongiulio Faggiano Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS “Fondazione G. Pascale”, Naples, Italy

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Gandhi M Steward DL Fidler JP Giordano TJ Biddinger PW Nikiforov YE 2006 Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas

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Simone De Leo Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Michela Perrino Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Sara Badiali Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Stefania Rossi Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Valentina Cirello Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Carla Colombo Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Delfina Tosi Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Gianmaria Cantoni Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Luca Poggi Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Gaetano Bulfamante Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Paolo Beck-Peccoz Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Leonardo Vicentini Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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Laura Fugazzola Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy
Department of Clinical Sciences and Community Health, Endocrine Unit Fondazione IRCCS Ca' Granda, Endocrine Surgery Unit, Fondazione IRCCS Ca' Granda, Unit of Pathological Anatomy, Department of Health Science, University of Milan, Milan, Italy

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nodes  NX 206 (83.1)  N0 26 (10.5)  N1 16 (6.4) Stage  I 216 (86.7)  II 5 (2)  III 22 (8.8)  IV 6 (2.4) Histotype  Papillary 228 (91.6)  Follicular 18 (7.2)  Medullary 2 (0.8)  NH lymphoma 1 (0.4) Histological variant papillary carcinoma  Classic 194 (82

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