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Tobias Zellweger
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Susanne Stürm Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Silvia Rey Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Inti Zlobec Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Joel R Gsponer Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Cyrill A Rentsch Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland
Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Luigi M Terracciano Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Alexander Bachmann Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Lukas Bubendorf Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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Christian Ruiz Department of Urology, Institute for Pathology, Institute of Pathology, Department of Urology, St Claraspital, Basel, Switzerland

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cells present on the arrayed specimens and applied a scoring system from 0 to 100 representing the percentage of stained tumor cells irrespective of staining intensity (see the Materials and methods section for further details). In addition, for AR, we

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0402
Volume/Issue:
Volume 20: Issue 3
Free access
Paraskevi Xekouki Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK

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Emily J Lodge Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Endocrinology and Diabetes, King’s College London, London, UK

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Jakob Matschke Institute of Neuropathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

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Alice Santambrogio Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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John R Apps Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK

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Ariane Sharif Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France

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Thomas S Jacques Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK

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Simon Aylwin Department of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK

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Vincent Prevot Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France

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Ran Li Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

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Jörg Flitsch Department of Neurosurgery, Hamburg University Medical Center, Hamburg, Germany

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Stefan R Bornstein Department of Endocrinology and Diabetes, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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Marily Theodoropoulou Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Cynthia L Andoniadou Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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& Inoshita 2018 ). YAP and TAZ expression was variable and was subdivided into three different groups based on a semiquantitative scoring system as described in the methods ( Fig. 2C , Table 1 ). Four out of ten null-cell tumours displayed high

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0330
Volume/Issue:
Volume 26: Issue 1
Open access
Annika Blank Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany
Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Anja M Schmitt Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Esther Korpershoek Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Francien van Nederveen Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Thomas Rudolph Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Nicole Weber Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Räto Thomas Strebel Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Ronald de Krijger Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Paul Komminoth Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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Aurel Perren Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany
Institute of Pathology, Department of Pathology, Department of Pathology, Department of Urology, Institute of Pathology, Department of Pathology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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sporadic tumours is an unsolved problem; the only definite evidence of malignancy is the detection of metastases. The ‘PCC of the adrenal gland scaled score (PASS)’, a morphological scoring system to identify more aggressive tumours ( Thompson 2002 ), has

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0316
Volume/Issue:
Volume 17: Issue 4
Free access
Päivi Siironen
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Ari Ristimäki
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Kirsi Narko
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Stig Nordling
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Johanna Louhimo
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Sture Andersson
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Reijo Haapiainen
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Caj Haglund
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papillary thyroid carcinoma: a retrospective analysis of surgical outcome using a novel prognostic scoring system. Surgery 102 1088 –1095. Hay ID , Bergstralh EJ, Goellner JR, Ebersold JR & Grant CS 1993 Predicting outcome

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01114
Volume/Issue:
Volume 13: Issue 2
Free access
Pablo Valderrabano Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Laila Khazai Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Marino E Leon Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Zachary J Thompson Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Zhenjun Ma Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Christine H Chung Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Julie E Hallanger-Johnson Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Kristen J Otto Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Kara D Rogers Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Barbara A Centeno Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Bryan McIver Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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reclassification on the results interpretation Upon review of histological specimens blinded to the molecular results, 5/7 (71%) NIFTPs were reclassified as benign neoplasms when a qualitative scale (scoring system) was applied ( Nikiforov et al. 2016 ). This

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0512
Volume/Issue:
Volume 24: Issue 3
Free access
Shih-Ping Cheng Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Chien-Liang Liu Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Ming-Jen Chen Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Ming-Nan Chien Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Ching-Hsiang Leung Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Chi-Hsin Lin Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Yi-Chiung Hsu Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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Jie-Jen Lee Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science
Department of Surgery, Division of Endocrinology and Metabolism, Mackay Junior College of Medicine, Department of Pharmacology, Department of Medical Research, Institute of Statistical Science

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was associated with larger tumor size, higher rate of extrathyroidal invasion, and more advanced TNM stage ( Table 2 ). MACIS scoring system developed at the Mayo Clinic uses metastasis, age, completeness of resection, local invasion, and tumor size to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0269
Volume/Issue:
Volume 22: Issue 2
Free access
Karin Jennbacken Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Tajana Tešan Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Wanzhong Wang Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Heléne Gustavsson Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Jan-Erik Damber Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Karin Welén Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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-cadherin score compared with tumors from patients without metastases (M0; 1.73 vs 0.78 respectively, P =0.048; Fig. 4 D). Figure 4 Expression of N-cadherin in human prostate cancer TURP specimens was evaluated by immunohistochemistry. A scoring system for the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0015
Volume/Issue:
Volume 17: Issue 2
Free access
Louis de Mestier Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

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Anne Couvelard Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

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Anela Blazevic Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Olivia Hentic Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France

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Wouter W de Herder Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Vinciane Rebours Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

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Valérie Paradis Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

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Philippe Ruszniewski Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

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Leo J Hofland Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Jérôme Cros Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

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dichotomized NETs in MGMT-deficient and MGMT-proficient with a very stringent cut-off (MGMT-deficient: no expression at all or in less than 10% of the cells). An alternative is to use a continuous scoring system to better reflect all the possibilities of MGMT

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0227
Volume/Issue:
Volume 27: Issue 10
Free access
M M Muresan Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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P Olivier Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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J Leclère Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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F Sirveaux Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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L Brunaud Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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M Klein Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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R Zarnegar Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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G Weryha Nuclear Medicine Department, Clinic of Traumatology and Orthopaedics, Digestive and Endocrine Surgery Department, Department of Surgery, Endocrinology Department and

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uptake, and spinal instability with or without neural compression. Various scoring systems guiding the surgical strategy are based on the primary tumor type, the presence of visceral metastases, and number of bone metastases ( Tokuhashi et al . 1990

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0229
Volume/Issue:
Volume 15: Issue 1
Free access
R Engers
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S Ziegler
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M Mueller
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A Walter
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R Willers
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H E Gabbert
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staining intensity. Immunoreactive scores were calculated by multiplying percentage score of positive cells times staining intensity score, yielding an end score of 0–12 ( Engers et al. 2006 a ). This scoring system was used in the present study

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-06-0036
Volume/Issue:
Volume 14: Issue 2
Free access