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carcinogenesis is still poorly defined. It has been demonstrated that WNT2 which is functionally related to WNT4 is an activity-dependent c-fos cAMP-response element binding protein (CREB)-responsive gene in neurons ( Wayman et al. 2006 ). The level of CREB
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Dame Roma Mitchell Cancer Research Laboratories and Freemasons Foundation Centre for Men’s Health, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia
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-response element binding protein (CREB) activation in prostate cancer models; CREB-induced H3K27me3, and neuroendocrine differentiation could be blocked by EZH2 inhibition ( Zhang et al . 2018 ). Mechanistically, activation of the CREB/EZH2 axis facilitates
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regulated by these trans acting factors although with some variation among species ( Endo et al. 1997 , Ohmori et al. 1998 , Ohno et al. 1999 , Taki et al. 2002 ). The NUE requires Pax-8 and cAMP-responsive element binding protein (CREB) for its
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& Spiegelman 2008 ). Modulation of PPARG-regulated pathways is thought to be important in PPFP carcinogenesis, and this is consistent with the observation that a different translocation fusing PPARG to the gene CREB3L2 also has been identified in FTC ( Lui
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transcription. Of note, multiple putative cis -regulatory elements have been previously identified in the HMOX1 promoter region including −146 to −37 bp for CREB ( Astort et al . 2016 ), −44 bp for Nrf2 ( Potteti et al . 2016 ) and −1036 to +1 bp for Sp1
Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China
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Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China
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Department of Gynecology, Department of Gynecologic Oncology, Systems Biology, Experimental Therapeutics, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fang Xie Road, Shanghai 200011, People's Republic of China
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, an anti-cJUN antibody, an anti-pAKT (Ser473) antibody, an anti-AKT antibody, an anti-pCREB (Ser133) antibody, an anti-CREB antibody, an anti-pIκB (Ser32) antibody, an anti-IκB antibody, and an anti-DR5 antibody were purchased from Cell Signaling
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Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA
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Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA
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negatively regulates the actions of CREB -dependent aromatase, the enzyme that catalyzes the synthesis of estrogens in breast adipose tissue, via phosphorylation of CRTC2 , a transcription factor required for the activation of the aromatase promoter PII in
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) whilst downstream partners such as p90 RSK can phosphorylate and enhance the activity of CREB binding protein (CBP) ( Nakajima et al. 1996 ) together with other factors associated with the basal transcription machinery. These findings may account for
Department of Endocrinology and Nutrition, Hospital Universitario de Móstoles, Madrid, Spain
Molecular Endocrinology Group, Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain
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Endocrine Tumors Unit, Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, Madrid, Spain
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(negatively regulated by SMAD3) binds to the NUE region and has a major role in NIS upregulation. Many other factors have been shown to bind to NUE regions such as CRE-like binding site (positively regulated by CREM, CREB1, ATF2, c-Fos, and c-Jun, or
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TRK1, CREB3L2-PPARG. The other somatic mutation groups include BRAF V600_K601E and TSHR S425I. The prevalence of RET/PTC isoforms is show in detail in the bottom panel. The prevalence and categories of mutations are detailed in Supplementary Tables